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Hydrogels in Orthopedic Tissue Engineering

Advances in Bone and Cartilage Regeneration

  • 1st Edition - May 15, 2026
  • Latest edition
  • Authors: Balaji Ayyanar Chinnappan, Elango Santhini, Trishna Bal, Faiza Sharif, N. S. Smrithi, Namrata Misra, Priyadarshini Pillai
  • Language: English

Hydrogels in Orthopaedic Tissue Engineering: Advances in Bone and Cartilage Regeneration is a comprehensive evaluation of new and existing biomaterials transforming orthop… Read more

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Description

Hydrogels in Orthopaedic Tissue Engineering: Advances in Bone and Cartilage Regeneration is a comprehensive evaluation of new and existing biomaterials transforming orthopedic care: in particular, it examines the science and application of hydrogels, showcasing their remarkable ability to mimic natural tissue environments, promote healing, and integrate seamlessly with the body. It reviews recent advances in hydrogel technology, including their design, synthesis, and functionalization for enhanced biocompatibility and mechanical properties. Each chapter provides an in-depth analysis of hydrogel-based strategies for repairing and regenerating bone and cartilage, addressing critical challenges such as vascularization, cell differentiation, and long-term stability. Through detailed case, the book offers invaluable insights for researchers, clinicians, and biomedical engineers

Key features

  • Provides a comprehensive and up-to-date resource that bridges the gap between cutting-edge research and clinical application in the field of regenerative medicine
  • By compiling real-world case studies, it addresses the urgent need for effective biocompatible solutions that can improve patient outcomes and advance the field of tissue engineering
  • Addresses the critical problem of effectively treating bone and cartilage injuries, which are often challenging due to the limited capacity for natural healing and the complexity of these tissues
  • Covers the design, synthesis, and application of hydrogels, detailing how these materials can be engineered to mimic the natural extracellular matrix, support vascularization, and deliver bioactive molecules that enhance tissue regeneration

Readership

Researchers in universities and research institutes involved in research on medicine, pharmacology and biomaterials

Table of contents

1. Introduction to hydrogels in regenerative medicine

2. Anatomy and physiology of bone and cartilage tissues

3. Pathologies and injuries requiring regeneration

4. Current challenges in bone and cartilage regeneration

4.1 Clinical applications of hydrogel-based therapies for specific bone or cartilage defects, highlighting patient outcomes and challenges encountered

4.2 Industrial development case studies, showcasing the journey from hydrogel design to commercialization of a medical device or therapy.

4.3 Research breakthroughs that demonstrate novel hydrogel formulations or fabrication techniques leading to improved regenerative outcomes in preclinical or clinical settings

4.4 Regulatory considerations and the commercial viability of hydrogel products

4.5 Patient outcomes and clinical trials of hydrogel-based therapies

5. Biomaterials for bone and cartilage tissue engineering

6. Hydrogel properties, types and design considerations for tissue engineering

6.1 Patient outcomes and clinical trials of hydrogel-based therapies

7. Design, fabrication and characterization of hydrogels for bone regeneration

7.1 Hydrogel synthesis and fabrication techniques, including chemical/physical crosslinking, 3d printing, and electro spinning.

7.2 Characterization methods for hydrogels, encompassing mechanical testing, chemical/structural analysis, and biological assessments.

7.3 In vitro and in vivo models for bone and cartilage regeneration, along with associated analytical techniques

8. Design fabrication and characterization of hydrogels for cartilage regeneration

9. Drug/cell encapsulation and delivery strategies in hydrogel systems

10. Cell-hydrogel interactions in tissue regeneration 11. Growth factors and signaling molecules in tissue engineering scaffold degradation and tissue integration

Product details

  • Edition: 1
  • Latest edition
  • Published: May 15, 2026
  • Language: English

About the authors

BC

Balaji Ayyanar Chinnappan

Assistant Professor Dr. C. Balaji Ayyanar, Mechanical Engineering Department, CIT obtained his Ph. D. in Mechanical Engineering (Biopolymer Composites) 2021 from Anna University (Coimbatore Institute of Technology), Master’s Degree in Mechanical Engineering (Computer Aided Design) 2008 from Anna University (Government College of Engineering, Salem), Bachelor’s in Mechanical Engineering 2006 from Anna University (S. R. M. Engineering College, Chennai). Assistant Professor Dr. C. Balaji Ayyanar holds (13 Years & 10 Months) years of experience in teaching (Lecturers at Bannari Amman Institute of Technology, Sathyamangalam, Erode. 638 401 and Assistant Professor at Vel Tech Multi Tech Dr. R.R & Dr. SR Engineering College, Avadi, Chennai-600 062) and 3 years in research and development (Combat Vehicle Research and Development Establishment, DRDO, Ministry of Defence) at Avadi, Chennai-54. This includes, modeling analysis and research experience working at different levels in Advanced Chassis and Automotive System (ACAS) renamed as MBT, in CVRDE, DRDO. He holds his specializations in Computer Aided Design, preparation of manufacturing drawing using AutoCAD, Modeling (Pro- E), analysis of machine elements using FEM. Working as an academician, Assistant Professor Balaji Ayyanar. C had contributed vividly both to industry and academia. His contribution includes 32 publications in International Journals, 07 Book Chapters, and 32 papers in international and national conferences and granted 10 design patents and filed three patents and 2 books.

Affiliations and expertise
Assistant Professor, Mechanical Engineering Department, Coimbatore Institute of Technology, India

ES

Elango Santhini

Dr. Elango Santhini is a Senior Scientific Officer at The South India Textile Research Association (SITRA), Coimbatore, India. She carried out her post-doctoral research at the Indian Institute of Science (IISc), Bangalore, India. She has over 10 years of experience in medical textiles. Her research interests include wound healing materials, hydrogel, antimicrobial textiles and tissue engineering.

Affiliations and expertise
Senior Scientific Officer, The South India Textile Research Association, Coimbatore, India

TB

Trishna Bal

Dr Trishna Bal is currently an Assistant Professor at the Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, India. Her research interests include natural polymers, graft copolymers, hydrogel, polymer composites, wound healing and nanofiber materials
Affiliations and expertise
Assistant Professor, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, India

FS

Faiza Sharif

Dr Faiza Sharif is currently working as a Tenured Associate Professor at the Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore Pakistan. She has a long career in Biological Science. She gained her PhD from Leiden University the Netherlands in 2011 and Post Doctorate from the Department of Materials Science and Engineering, University of Sheffield UK in the field of biomedical materials and tissue engineering. She has been working in the field for over 10. Her research interests include development of degradable biomedical materials for treatment of hard and soft tissue defects
Affiliations and expertise
Tenured Associate Professor, Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore Pakistan

NS

N. S. Smrithi

Dr. N. S. Smrithi is currently pursuing her third year of Prosthodontics Senior Residency from The Tamil Nadu Dr M.G.R Medical University and has wide expertise in the field of Prosthodontics and Implantology. She completed her Bachelors in Dental Surgery from The Tamil Nadu Dr M.G.R Medical University (Sri Ramakrishna Dental College) in 2022. Her current research areas include hydrogels, dental material sciences and Implantology
Affiliations and expertise
RVS Dental College, India

NM

Namrata Misra

Dr. Namrata Misra, Chief Executive Officer of Bhubaneswar City Knowledge Innovation Cluster (BCKIC), an initiative of the Office of the Principal Scientific Adviser to the Government of India, leads transformative initiatives strengthening the regional innovation and national mission driven programs. She brings over a decade of experience at KIIT-TBI, where she serves as Advisor and formerly in key roles fostering entrepreneurship, and is also an Associate Professor at the KIIT School of Biotechnology, bridging academia, research, and industry for meaningful impact
Affiliations and expertise
Chief Executive Officer of Bhubaneswar City Knowledge Innovation Cluster (BCKIC)

PP

Priyadarshini Pillai

Dr Priyadarshini Pillai is an Assistant Professor and Head of Department at Jyoti Nivas College, Bangalore, a position she has held since May 2017. Her earlier roles include Project Scientist at the R.K. Institute of Management and Computer Science (June 2012 - April 2014) and Research Scientist at GVK Bio-campus (December 2007 - May 2012. Dr Pillai began her academic career as a Lecturer and Research Scholar at Vikram University (July 2003 - December 2006) and as a Lecturer at Government Madhav Science College
Affiliations and expertise
Assistant Professor and Head of Department, Jyoti Nivas College, Bangalore, India