Imaging Blood-Brain Barrier Dysfunction in Brain Disorders
- 1st Edition - November 24, 2025
- Latest edition
- Authors: Danny J.J. Wang, Xingfeng Shao
- Language: English
Imaging Blood-Brain Barrier Dysfunction in Brain Disorders delves into the intricate structure and function of the blood-brain barrier (BBB), examining its essential role in the pa… Read more
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Description
Description
Furthermore, the book explores BBB anomalies in brain disorders like stroke, traumatic brain injury, cerebral small vessel disease, Alzheimer's disease, and sleep apnea. It highlights modern medical imaging technologies, such as MRI, for observing BBB function in vivo. It emphasizes the importance of BBB imaging for monitoring and potentially curing brain disorders, and discusses its potential in the early detection of neurological disorders, allowing for timely and effective treatment strategies.
Key features
Key features
- Explains the biology of BBB, its role in maintaining the normal brain function (e.g. aging and sleep), and its aberrations in brain disorders (e.g. stroke, cSVD, AD, TBI, sleep apnea)
- Shows how modern medical imaging technologies, in particular MRI, can visualize BBB function in both the healthy and diseased brain
- Includes multimedia contents, including videos and graphic illustrations to help readers understand the materials
Readership
Readership
Table of contents
Table of contents
1.1 Structure and function of BBB
1.2 BBB and glymphatic system
1.3 BBB variation with aging and circadian rhythm
2. Imaging of BBB function
2.1 Nuclear medicine approaches
2.2 MRI measurement of BBB permeability
2.3 MRI measurement of BBB water exchange
3. Imaging natural variation of BBB function
3.1 Imaging BBB function with aging and between genders
3.2 Imaging BBB function during sleep
4. Imaging BBB dysfunction in brain disorders
4.1 Dementia (AD, PD etc)
4.2 Stroke
4.3 Cerebral small vessel disease (cSVD)
4.4 Brain tumor
4.5 Psychiatric diseases (Schizophrenia, depression etc)
5. Imaging BBB for treating brain disorders
5.1 Therapeutic targets and drug delivery across the BBB
5.2 Transit BBB opening using focused ultrasound (FUS)
6. Looking into the future
6.1 Emerging technologies in BBB imaging (ultrahigh field)
6.2 Challenges and opportunities in BBB research
6.3 Ethical considerations and future directions in BBB studies
Product details
Product details
- Edition: 1
- Latest edition
- Published: November 25, 2025
- Language: English
About the authors
About the authors
DW
Danny J.J. Wang
Dr. Danny JJ Wang is currently the Professor of Neurology and Radiology, and Director of Imaging Technology Innovation at the Stevens Neuroimaging and Informatics institute, Keck School of Medicine at USC, as well as head of the Laboratory of Functional MRI Technology (LOFT). During the past 25 years, his research has been focused on the technical development and clinical translations of novel functional and physiological MRI technologies. He is a recognized expert in perfusion and functional MRI and has extensive experience in clinical applications related to cerebrovascular disorders, dementia and neurodevelopment. Dr. Wang was elected Senior Fellow of the ISMRM in 2022.
XS
Xingfeng Shao
Dr. Xingfeng Shao is an Assistant Professor of Radiology at USC Stevens Neuroimaging and Informatics institute, Keck School of Medicine at USC. His research focuses on the development and applications of innovative MR image acquisition in normal and diseased populations, particularly in perfusion MRI, laminar ASL fMRI at ultra-high field and blood-brain barrier (BBB) function. Dr. Shao been actively participating international MRI societies and received prestigious awards such as the ISMRM I.I. Rabi Young Investigator finalist (2023), ISMRM W.S. Moore Young Investigator finalist (2018), ISMRM Junior Fellow, OCSMRM young investigator award and ISNVD young investigator award.