Immunological Tolerance

Participants

Preface

Photographs of Participants

Session I: T Cell Tolerance

Factors Influencing the Rate of Induction of Tolerance by Bovine Gamma Globulin

Discussion following David Dresser

Interactions of T and B Lymphocytes in Self-Tolerance and Autoimmunity

Discussion following Anthony Allison

The Cellular Basis for Establishing Tolerance or Immunity to Bovine γ-Globulin in Mice

The Role of Accessory and Thymus-Derived Cells in Resistance to Tolerance Induction

Suppressor Activity in Mice Tolerant of Hemocyanin

Specific Suppression of the Immune Response by T Cells

Tolerance to Contact Sensitivity—a Role for Suppressor T Cells?

General Discussion—Session I

Session II: B Cell Tolerance

Activation of and Tolerance Induction in DNP-Specific B Cells: Analysis with Three Distinct DNP-Carrier Conjugates

Discussion following William E. Paul

Three Catergories of B Cell Tolerance Induced by Polysaccharides: Characteristics, Interrelationships and General Implications

Discussion following James Howard

Effect of Tolerance on Antibody-Binding Affinity

Hapten-Specific Tolerance Induced by the DNP Derivative of D-Glutamic Acid and D-Lysine (D-GL) Copolymer

Tolerance in Isolated B-Cell Populations Identified by an Allotype Marker: Role of T Cells in Induction

B Cell Tolerance Induced by Non-Metabolized or Toxic Antigens

Effect of Epitope Density on the Induction of Tolerance In Vitro

General Discussion—Session II

Session III: Mechanisms of B Cell Tolerance

Reversible and Irreversible B Cell Tolerance: Distinguishing Properties and Mechanisms

Discussion following David H. Katz

High-Dose Tolerance in Mice Deficient in Reactive T Cells

Discussion following Graham F. Mitchell

Functional Relationships in Antigen-Receptor Interactions in B Lymphocytes

B Cell Tolerance In Vitro—the Fate of the Tolerant Cell and Its Control by Hormones

Graft-versus-Host Reactions, Tumor-Specific Immunity and Self-Tolerance

Receptor Blockade by Tolerogen: One Explanation of Tolerance

General Discussion—Session III

Session IV: Mechanisms of T Cell Tolerance

Unifying Concepts in Tolerance Induction for Various T and B Cell Sub-Populations

Discussion following G.J.V. Nossal

Cellular Parameters of the Tolerant State Induced to Human γ Globulin in

Mice and of Its Modulation by Bacterial Lipopolysaccharides

Discussion following Jacques M. Chiller

Effect of Antigen Structure on the Induction of Tolerance in T Cells

Indications of Active Suppression in Mouse Carriers of Lymphocytic Choriomeningitis Virus

Interactions between T Cells Which Result in Suppression of T Cell Functions

General Discussion—Session IV

Session V: Activity of Suppressor Cells as a Mechanism of Tolerance

Introduction

Lack of Activity of Contra-Suppressor T Cells as a Mechanism of Tolerance

Discussion following Richard K. Gershon

The Mode and Sites of Action of Suppressor T Cells in the Antigen-Induced Differentiation of B Cells

Discussion following Tomio Tada

The Role of Suppressor T Cells in the Development of Low-Dose Paralysis to Type III Pneumococcal Polysaccharide

Are Suppressor T Cells Responsible for Tolerance to a Soluble Antigen?

Stimulation of Specific Suppressor T Cells by the Terpolymer L-Glutamic Acid60—L-Alanine30—L-Tyrosine10 in Genetic Non-Responder Mice

Mechanism of Allotype Suppression in Mice

Remarks on Allotype Suppression in Rabbits

General Discussion—Session

Session VI: Suppressive Activity of Antibody and Antigen-Antibody Complexes

Is There a Unifying Concept for Diverse Models of Tolerance Induction?

Discussion following Erwin Diener

Blocking Factors in Tumor Immunity and Allograft Tolerance

Discussion following Karl-Erik Hellstrom

Antibody-Mediated Tolerance

IgE Antibody-Specific Abrogation of an Established Immune Response in Mice by Modified Antigens

General Discussion—Session

Session VII: Summary and Potential Therapeutic Applications

General Discussion—Session VII

Closing Comments