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Elsevier

Innovative Brain Tumor Therapy

  • 1st Edition - October 10, 2014
  • Latest edition
  • Authors: Gerardo Caruso, Lucia Merlo, Maria Caffo
  • Language: English

Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain… Read more

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Description

Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.

Readership

All neuroscientists with interest in brain tumor treatment, medical students, researchers, oncologists, neurologists and neurosurgeons.

Table of contents

  • List of figures
  • List of abbreviations
  • About the authors
  • Introduction
  • 1: Brief introduction on brain tumor epidemiology and state of the art in therapeutics
    • Abstract
  • 2: Blood–brain barrier pathophysiology in brain tumors
    • Abstract
  • 3: Brain drug-delivery attempts
    • Abstract
  • 4: Nanoparticles potential: types, mechanisms of action, actual in vitro and animal studies, recent patents
    • Abstract
    • 4.1 Nanomedicine and nanoparticles: general overview
    • 4.2 Main types of nanoparticles for drug-delivery systems
    • 4.3 Application in brain tumors
    • 4.4 Recent patents in brain tumors
    • 4.5 Nanotechnology
  • 5: Future scenarios: nanoparticles and stem cells
    • Abstract
  • 6: Conclusions
  • Index

Review quotes

"...a well-written description of this potential therapy for glioblastoma…a well-done contribution to therapeutic knowledge. Score: 93 - 4 Stars"—Doody's

"...presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment...Relevant patents of nanoparticles used as drug delivery carriers are also reported…"—Anticancer Research

Product details

  • Edition: 1
  • Latest edition
  • Published: October 30, 2018
  • Language: English

About the authors

GC

Gerardo Caruso

Gerardo Caruso is Neurosurgeon at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy.
Affiliations and expertise
University of Messina, Italy

LM

Lucia Merlo

Lucia Merlo is Neurosurgeon at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy.
Affiliations and expertise
University of Messina, Italy

MC

Maria Caffo

Maria Caffo is Assistant Professor in Neurosurgery, Ph.D in Neurooncology at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy.
Affiliations and expertise
University of Messina, Italy

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