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Ketamine

Fundamentals, Applications, Pharmacology, and Clinical Aspects

  • 1st Edition - October 6, 2025
  • Latest edition
  • Editors: Albert Dahan, David Dadiomov
  • Language: English

Pharmacology of Ketamine: Fundamentals, Applications, Delivery Systems and Clinical Aspects explores the multifaceted properties of ketamine for diverse applications, delvin… Read more

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Description

Pharmacology of Ketamine: Fundamentals, Applications, Delivery Systems and Clinical Aspects explores the multifaceted properties of ketamine for diverse applications, delving into dosing strategies, routes of administration, and their pharmacological implications. The book begins with an introduction that underscores the need to bridge research and practice. It then delves into the pharmacological intricacies of ketamine, dissecting mechanisms and dosing strategies and exploring the diverse routes of administration and their impact on ketamine's metabolites.

The book then explores the PK and PD characteristics of ketamine, followed by a deep dive into clinical applications emphasizing anesthesia, psychiatric therapy, and emerging treatments. The final part of the book covers addiction, toxicity, and future research perspectives. It will serve as a comprehensive reference tailored to the needs of both researchers and clinicians involved in the administration and study of ketamine.

Key features

  • Summarizes current literature and evidence based research of ketamine from a pharmacological and clinical perspective
  • Provides an interdisciplinary perspective on the use of ketamine in research and clinical settings
  • Considers the future research directions of ketamine

Readership

Researchers in Pharmacology and Neuropharmacology

Table of contents

1. Ketamine and its metabolites – mechanism of action

2. Ketamine pharmacokinetics and pharmacodynamics

3. Ketamine effects on brain dynamics

4. Ketamine for depression and other psychiatric diseases
5. Undestanding ketamine subjective effects
6. Ketamine for acute and chronic pain
7. Ketamine for neuropathic pain: animal and human studies

8. Ketamine for addiction treatment
9. Cardiorespiratory effects of ketamine

10. Ketamine toxicity: translating preclinical findings to adverse effects in humans
11. Recreational use of ketamine

12. Ketamine in the era of the opioid crisis

13. Future Perspectives

Product details

  • Edition: 1
  • Latest edition
  • Published: October 27, 2025
  • Language: English

About the editors

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Albert Dahan

Albert Dahan received his MD at the VuMC Amsterdam (1986) and his PhD in 1990 at Leiden University. The title of his dissertation was The ventilatory response to CO2 and O2 in man: methods and implications. Part of the research was performed in the US (UCLA).

After he became an anesthesiologist (1995), he worked at Leiden University Medical Center as anesthesiologist and founded the Anesthesia & Pain Reseacrh Unit. Research was and is performed in several facilities including the animal research lab, the cardiorespiratory lab, the pain lab and the OR and PACU.

He was appointed as professor is 2004 and gave his inaugural speech in 2005 (May 25, entitled Bij Kennis, or Awake with Wisdom).

Dahan is member of several prestigious American and European editorial boards, such as the of the US journals Anesthesiology, Pain and European Journal European Journal of Pain.

Dahan is member of several international advisory boards relating to perioperative care and opioids and is co-author of several internal guidelines.

Affiliations and expertise
Leiden University Medical Center, The Netherlands

DD

David Dadiomov

David Dadiomov, PharmD, BCPP, is a clinical assistant professor of pharmacy practice in the Titus Family Department of Clinical Pharmacy.

He received his PharmD from the University of Michigan College of Pharmacy. He completed his PGY1 Pharmacy Residency at Michigan Medicine, and his PGY2 Psychiatric Pharmacy Residency at University of California, San Diego, Health. He holds board certification in psychiatric pharmacy.

Dadiomov serves as the director of the PGY2 Psychiatric Pharmacy Residency Program. He maintains clinical practice in addiction medicine at Los Angeles General Medical Center. In this role he provides consultations in psychiatry and addiction as well as seeing patients in the Complex Care Clinic. Dadiomov has worked with the LA County Department of Health Services to establish novel clinical pharmacy services for patients experiencing homelessness, patients currently or recently released from incarceration, as well as those with severe mental illness and addiction disorders.

Affiliations and expertise
University of Southern California, USA

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