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Melanin-Concentrating Hormone

From Metabolism to Sleep Disorders

  • 1st Edition - October 1, 2026
  • Latest edition
  • Editors: Jackson C. Bittencourt, Carol Elias
  • Language: English

Melanin-Concentrating Hormone: From Metabolism to Sleep Disorders, the latest volume in the Molecular Mediators in Health and Disease series, offers a comprehensive understanding… Read more

Description

Melanin-Concentrating Hormone: From Metabolism to Sleep Disorders, the latest volume in the Molecular Mediators in Health and Disease series, offers a comprehensive understanding of this multifunctional peptide. The book covers a wide range of topics, including molecular biology of MCH, MCH in organ function, pharmacology, and MCH in disease. Recent developments in MCH imaging and pharmacological modulation are explored, along with the impact of MCH in psychiatric and neurodegenerative disorders and its role in the neuroimmunological modulation of vitiligo. Additionally, MCH is considered in the context of reproductive behavior, sleep, cognition, memory, and peripheral function.

The book also explores MCH across various species such as humans, reptiles, non-primate mammals and teleosts. This is an ideal reference for researchers working with MCH across the fields of cell biology, molecular biology, pharmacology, neuroscience, endocrinology, and beyond.

Key features

  • Examines genetic and molecular aspects of the melanin-concentrating hormone (MCH)
  • Considers MCH in the context of disease, including addiction, neurodegenerative, psychiatric, and eating disorders
  • Explores MCH across various organ function
  • Covers MCH in non-rodent biology

Readership

Researchers at PhD level and above across biological and biomedical sciences including cell biology, molecular biology, pharmacology, neuroscience and endocrinology

Table of contents

Part 1: Introduction to MCH

1. Introduction

2. Melanin-concentrating hormone: a bibliometric perspective

Part 2: Molecular Biology of MCH

3. The Melanin-Concentrating Hormone and its Receptors

4. Genetic and Molecular Aspects of the Melanin-Concentrating Hormone: “From the Gene to the Peptide”

5. MCH Neurons, Neurotransmitters and Co-modulators

6. Synaptic Functions of MCH

7. Non-synaptic mechanisms of MCH communication

Part 3: MCH in Organ Function

8. Energy Homeostasis

9. Reproductive Behavior

10. Sleep

11. Cognition and Memory

12. Peripheral Actions of MCH

Part 4: MCH Pharmacology

13. Development and application of in vivo MCH tracers

14. Agonists and Antagonists

Part 5: MCH in Non-Rodent Biology

15. Mediator in Non-Mammalian Biology: Overview of the Evolutionary Aspects of MCH

16. MCH in Teleosts

17. MCH in Reptiles and Non-Primate Mammals

18. MCH in Humans Part 6: MCH in Disease

19. MCH and Addiction

20. MCH and Psychiatric Disorders

21. MCH and Neurodegenerative Diseases

22. Lactation/Maternal Behavior

23. Mental Disorders/stress-related sleep mood and MCH

24. Measuring circulating MCH in humans and eating disorders

Product details

  • Edition: 1
  • Latest edition
  • Published: October 1, 2026
  • Language: English

About the editors

JB

Jackson C. Bittencourt

Dr. Bittencourt is Full Professor of the Department of Anatomy and Head of the Laboratory of Chemical Neuroanatomy at the Institute of Biomedical Sciences, University of Sao Paulo, Brazil. He has served on multiple major University and Faculty committees while at the same time maintaining a significant research group and an extensive publication output. During his career spanning almost four decades, he has supervised more than 50 Master, Doctorate students, and Postdoctoral Fellows. He is the author of over 150 original articles, reviews, books, and book chapters. He has supervised Ph.D. students, many of whom now hold significant academic and other positions throughout Brazil and internationally.

Affiliations and expertise
Laboratory of Chemical Neuroanatomy Department of Anatomy Institute of Biomedical Sciences University of Sao Paulo Av. Prof. Lineu Prestes, São Paulo, Brazil

CE

Carol Elias

Professor Carol Elias earned a PhD in Neuroscience and Behavior from the University of São Paulo, Brazil. She completed the postdoctoral training in Neuroscience and Neuroendocrinology at Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA. After her postdoctoral training, she returned to Brazil to establish a research program at the Institute of Biomedical Sciences at the University of Sao Paulo, where she worked for approximately 10 years. In 2006, she returned to the United States for a 1-year sabbatical at the University of Texas Southwestern Medical Center in Dallas, TX. She was invited to join the faculty at the Division of Hypothalamic Research. In 2013, she moved to the University of Michigan in Ann Abor, MI. She currently holds the position of Professor in the Departments of Molecular & Integrative Physiology and Obstetrics & Gynecology at University of Michigan. She is the Director of the Neuroscience Graduate Program and the Director of the Michigan Mouse Metabolic Phenotyping Center (MMPC-Live), a National Center funded by the NIDDK. She is a member of the Latin American Academy of Sciences (ACAL) and a fellow of the American Academy for the Advancement of Sciences (AAAS).

Affiliations and expertise
Professor of Molecular and Integrative Physiology, Professor of Obstetrics and Gynecology, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA