Method Development in Analytical HPLC
- 1st Edition - October 22, 2024
- Latest edition
- Authors: Serban C. Moldoveanu, Victor David
- Language: English
Method Development in Analytical HPLC presents the essential information for understanding the process of developing an HPLC method of analysis. It includes foundational informati… Read more
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Description
Description
Method Development in Analytical HPLC presents the essential information for understanding the process of developing an HPLC method of analysis. It includes foundational information related to HPLC, as well as discussion of sample types, the properties of analytes and matrices in the samples, and sample preparation. The core of the book describes the best ways for approaching method development in various types of HPLC and the criteria for method optimization and validation.
This book provides clear guidance for adopting analytical methods from the literature and describes the development of original methods with selection of the suitable type of HPLC, of specific columns, mobile phase, and detection techniques with an emphasis on the use of mass spectrometry for detection, as well as optimization and validation of the chosen analytical method. The book includes useful details on method development for specific types of chromatography such as RP-HPLC, HILIC, ion exchange, size exclusion, and chiral.
Method Development in Analytical HPLC also includes information about green chemistry in analytical methods, computer assisted method development, and other key contemporary aspects of the subject.
Key features
Key features
- Offers a systematic and logical presentation of the foundational of analytical HPLC
- Goes in-depth on method development for specific types of chromatography such as RP-HPLC, HILIC, ion exchange, and size exclusion
- Includes methods with an emphasis on the use of mass spectrometry for detection
Readership
Readership
Table of contents
Table of contents
2. Retention and elution processes in HPLC
3. Instrumentation in HPLC
4. Performance and utilization of HPLC separation and detection
5. Samples for HPLC analysis
6. Sample preparation for an HPLC analysis
7. Chromatographic columns in HPLC
8. Mobile phase and the role of solvents in HPLC
9. Development of an HPLC analytical method
10. Selection of the best options in developing an HPLC analytical method
11. Method and data validation in HPLC analysis
Product details
Product details
- Edition: 1
- Latest edition
- Published: October 24, 2024
- Language: English
About the authors
About the authors
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Serban C. Moldoveanu
Dr. Serban C. Moldoveanu held several teaching positions at the University of Bucharest, Romania, until 1983, when he immigrated to the United States. There, he continued teaching at the university level for several years before focusing primarily on industrial research. He served as Senior Principal Scientist at R.J. Reynolds Tobacco Company and retired at the end of 2023. His research has centered on various aspects of chromatography, including method development for the analysis of natural products using GC/MS, HPLC, and LC/MS/MS. He has also investigated the pyrolysis of a variety of polymers and organic compounds. Dr. Moldoveanu has published more than 150 articles in peer-reviewed journals, 8 books with Elsevier, approximately 22 patents/patent applications, and several book chapters. He was honored with the Tobacco Science Research Conference Lifetime Achievement Award in 2012 and currently serves as an editor for three chemistry journals.
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