Microglial Aging
Basic, Translational and Clinical Advances
- 1st Edition - February 13, 2026
- Latest edition
- Editor: Marie-Eve Tremblay
- Language: English
Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves… Read more
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Description
Description
This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.
Key features
Key features
- Covers basic, translational, and clinical research advances in microglial aging
- Reviews the most up-to-date research findings on microglial aging and their implication in age-related neurodegenerative diseases
- Includes current knowledge on the effects of lifestyle on microglial aging and on promising strategies, both pharmacological and non-pharmacological, for rejuvenating microglia
Readership
Readership
Table of contents
Table of contents
1 Introduction to microglial aging and its involvement in neurodegenerative diseases
Benneth Ben-Azu, Makenna Gargus, Alexei Verkhratsky, Marie-Éve Tremblay
2 Involvement of microglial aging in neurodegenerative diseases: a focus on Parkinson’s disease
Luca Ballotto, Gurkirat Kaur, Luigi Bubacco, Laura Civiero, Elisa Greggio
3 Involvement of microglial aging in neurodegenerative diseases: a focus on multiple sclerosis
Paschalis Theotokis
4 Involvement of microglial aging in neurodegenerative diseases: a focus on amyotrophic lateral sclerosis
Myriam Catalano, Cristina Limatola
SECTION 2: Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory
5 Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory: diet and the gut-brain axis
Sarah Nicolas, Yvonne M. Nolan
6 Sleep disturbance as a modulator of microglial morphology and function: implications for neurodegenerative disease
Danique C. Zantinge, Robbert Havekes, Peter Meerlo, Nicole J. Gervais
7 The effects of bacterial and viral infections on microglia
Sofya Ermolina, Dawn M.E. Bowdish
8 Physical activity and microglial metabolism in neurodegenerative diseases
Megumi Andoh, Ryuta Koyama
SECTION 3: Emerging treatment strategies to rejuvenate microglia in aging and neurodegenerative diseases
9 Microglial senescence and senolytic drugs
Benneth Ben-Azu, Salomé Sabbah, Ifeoluwa O. Awogbindin, Emmanuel O. Chidebe, Benjamin Oritsemuelebi, Disha Patel, Dan Frenkel, Marie-Éve Tremblay
10 Cannabinoids as modulators for Alzheimer’s disease: a role for microglia?
Haley A. Vecchiarelli
11 Psychedelics and microglia in aging: unraveling the secret dialogue behind healthy aging, mental health, and neuroinflammation
Antonio Inserra, Jared VanderZwaag, Antonella Campanale, Colin Murray, Attila Szabo
12 Effects of plasmalogens on microglial function and neuroinflammation: mechanisms and implications in aging and neurodegenerative diseases
Zijian Xu, Yuru Deng
Appendix: Epilogue
Angelova A., Deng Y.
Index
Product details
Product details
- Edition: 1
- Latest edition
- Published: February 21, 2026
- Language: English
About the editor
About the editor
MT
Marie-Eve Tremblay
Dr. Marie-Ève Tremblay is a Full Professor at the School of Medical Sciences, University of Victoria, British Columbia, Canada. She was awarded a Tier II Canada Research Chair in Neurobiology of Aging and Cognition until 2025. Dr. Tremblay is an internationally recognized leader in microglial research. Her career goal is to become a world leader in the development of innovative therapies normalizing microglial functions upon exposure to various environmental risk factors for disease throughout life. She has been invited to present her work over 143 times, at seminars, lectures at symposia, specialized courses, and other meetings. She has 182 publications cited 11,854 times, corresponding to an h-index of 50 and i10-index of 116 (Google Scholar). She was also named a Clarivate Highly Cited Researcher, being among the top 1% across fields in 2021 and 2022 and is ranked 4th world microglial expert by ExpertScape.