Skip to main content

Mitochondrial Genomics

Insights into Dysfunction and Disease

  • 1st Edition - August 1, 2026
  • Latest edition
  • Authors: Aruna Pal, Keshav K. Singh
  • Language: English

Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitoch… Read more

World Book Day celebration

Where learning shapes lives

Up to 25% off trusted resources that support research, study, and discovery.

Description

Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics.

Key features

  • Introduces mitochondrial genetics and function using animal models
  • Discusses the role of mitogenomics in various disease states
  • Considers the implication of whole mitochondrial genome sequencing in animals
  • Explores mitochondrial replacement theory and gene editing

Readership

Academic researchers and industry scientists in the fields of animal disease resistance, immunology, and mitogenomics

Table of contents

1. Overview of mitochondria

2. Structural organization of mitochondria and mitochondrial genetics in different animal models

3. Mitophagy

4. Introduction to MAVS in different livestock species

5. Mitogenomics and metabolic disease

6. Mitogenomics and viral disease

7. Mitogenomics and bacterial disease

8. Mitogenomics and parasitic disease

9. Mitogenomics and fungal infestations

10. Mitogenomics and neurodegenerative disorder

11. Mitogenomics and cancer

12. Numtogenesis and its association to disease

13. Whole mitochondrial genome sequencing and its implication in diseases in animal models

14. Mitochondrial replacement therapy: Its prospects

15. Implication of gene editing in mitochondrial repair

Product details

  • Edition: 1
  • Latest edition
  • Published: August 1, 2026
  • Language: English

About the authors

AP

Aruna Pal

Dr. Aruna Pal is Assistant Professor at West Bengal University of Animal and Fishery Sciences (WBUASFSCI). She obtained her MVSc at the National Dairy Research Institute, India, and her PhD in Animal Genetics and Breeding at the Indian Veterinary Research Institute. She has acted as Convenor for the Human Genetics and Genomics Task Force for India’s Ministry of Science and Technology and currently heads the Animal Genomics lab for WBUASFSCI’s Department of Animal Genetics and Breeding. Her research focuses on mitochondrial genetics and diseases using animal models. She has authored multiple books, including Elsevier’s Genetics and Breeding for Disease Resistance of Livestock.

Affiliations and expertise
West Bengal University of Animal and Fishery Sciences, India

KS

Keshav K. Singh

Dr. Keshav Singh is Professor of Genetics and Endowed Chair within the University of Alabama at Birmingham’s Genetics Research Division. He obtained his MSc in India, PhD in Australia, and postdoctoral studies at Harvard University. He is a leader in the field of mitochondrial determinants of health, disease, diversity, and health disparities. He is the founding Editor-in-Chief of Elsevier’s Mitochondrion journal, founder of the Mitochondria Research and Medicine Society (USA), and founder of the Society for Mitochondrial Research and Medicine (India).
Affiliations and expertise
University of Alabama at Birmingham, USA