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Elsevier

Mitophagy in Health and Disease

Mechanisms, Health Implications, and Therapeutic Opportunities

  • 1st Edition - November 28, 2024
  • Latest edition
  • Editor: John J. Lemasters
  • Language: English

Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostas… Read more

Description

Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention.

This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.

Key features

  • Covers biologic machinery and mechanisms involved with mitophagy
  • Explores changes in mitophagy across the human lifespan
  • Points out directions in targeting mitophagy with therapeutic interventions

Readership

Graduate students and researchers in cell and molecular biology at the PhD level, Established researchers in other areas, seeking a deeper understanding of mitophagy will also find this book helpful in becoming proficient in the area, Research physicians in medical fields involved with mitochondrial issues, including pneumologists, cardiologists, neurologists and others

Table of contents

About the editor
Preface

1. PINK1-Parkin mitochondrial quality control pathway in Parkinson’s disease

2. Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions

3. Role of AMPK/ULK1 signaling in mitophagy

4. Mitochondrial proteostasis mechanisms (AAA proteases including Lon, proteasomes, CLpP)

5. MitoUPR

6. Mitochondria Derived Vesicles: from Quality Control to Inflammation and Extracellular Vesicles

7. Molecular Regulation of Mitochondrial Turnover by Exercise: Tissue Adaptation through Mitochondrial Biogenesis and Mitophagy

8. Role of mitophagy and mitochondria in aging and cellular senescence

9. Mitophagy in erythropoiesis

10. The dual role of mitophagy in cancer and its targeting for effective anticancer therapy

11. Mitophagy in brain and neurodegenerative disease

12. Anti-aging role of mitophagy

13. Mitophagy in age-associated disease

14. Mitophagy inducers as potential therapeutic agents

15. Transcription factor EB (TFEB) in mitochondrial quality control

16. Cardioprotection through mitophagy

17. Fasting, mitophagy, and aging

18. Aldehydes, Mitophagy, and the Pathogenesis of Alcohol-Associated and Metabolic Dysfunction-Associated Steatohepatitis

19. Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis

20. Mitophagy in Yeast

21. Sphingolipid metabolism in the regulation of mitophagy: Implications in cancer therapy, immune cell function and neurodegeneration

22. Formation of mitophagosomes

23. Mitophagy in Hepatic Ischemia/Reperfusion

Product details

  • Edition: 1
  • Latest edition
  • Published: November 29, 2024
  • Language: English

About the editor

JL

John J. Lemasters

Dr. Lemasters' research is focused on developing and applying new techniques of laser scanning confocal and multiphoton microscopy to characterize the physiology of single living cells, including the assessment of ion homeostasis, mitochondrial function, electrical potentials, oxygen and nitrogen free radical formation, membrane permeability and other biochemical parameters during the pathogenesis of lethal cell injury.
Affiliations and expertise
Professor and GlaxoSmithKline Distinguished Endowed Chair, Director, Cell & Molecular Imaging Core, Departments of Drug Discovery and Biomedical Sciences and Biochemistry and Molecular Biology, Medical University of South Carolina, USA

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