Molecular Diversity and Combinatorial Chemistry

Nature: The Original Combinatorial Chemist Biopolymers constitute natural libraries Selection and evolution The expression of genetic information Combinatorial assembly of antibody genes Molecular solutions to combinatorial problems Synthetic Peptide LibrariesSolid-phase peptide synthesis Peptides on pins Other iterative deconvolution strategies Examples of split/couple/mix peptide libraries Positional scanning Epilogue Supports, Linkers, and Reagents for Peptide SynthesisPolystyrenes PEG-grafted supports Coupling strategies Supports and Linkers for Small Molecule Synthesis New resins and linkers Ring-forming cleavage Loading Encoded Combinatorial ChemistryDirected Sorting Unnatural Oligomers for Library Synthesis Peptoids Azatides Peptidyl phosphonates Oligoureas Analytical Methods for Solid-phase Synthesis Product identification Gel-phase NMR High-resolution magic angle spinning NMR On-bead infrared spectroscopy Mass spectrometry Non-spectroscopic methods Supported Solution-phase Synthesis Polyethylene glycols Dendrimers Fluorous synthesis Solution-phase Parallel Synthesis Scavenging resins Ion-exchange resins Supported reagents Fluorous reagents Solid-phase extraction Gas-phase separation Multi-component Reactions Chemical Informatics, Diversity, and Library Design Strategies Representative flowchart for a library design Lipinski's Rules Nucleic Acid Microarrays Combinatorial Materials Chemistry Combinatorial Catalyst Discovery Peptides on Phage Applications of phage display Nucleic Acid Selection Complex Combinatorial and Solid-phase Synthesis Epibatidine Mappicine Dysidiolide The Big Picture