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Nanobioanalytical Approaches to Medical Diagnostics

  • 1st Edition - June 21, 2022
  • Latest edition
  • Editors: Pawan Kumar Maurya, Pranjal Chandra
  • Language: English

Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devi… Read more

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Description

Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices are used in various bioanalytical and biochemical systems to provide real-time, point-of-care diagnostics. The specialized properties of nanoparticles allow them to be engineered and adapted to produce the required effect within a bioanalytical or biochemical system – offering targeted and detailed diagnostic results in a range of biomedical applications.

This book covers both traditional biochemical and modern, combined nano-approaches to medical diagnostics. Chapters detail a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including DNA and peptide-based, erythrocyte, microfluidic and more. In addition, sections also look at various different medical diagnostic applications, such as in cancer detection, infectious disease diagnosis and blood glucose sensing.

Key features

  • Covers core principles and nano-approaches in bioanalytics for medical diagnostics
  • Details a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including spectroscopic analysis, erythrocyte models, microfluidics, and more
  • Appeals to an interdisciplinary readership, spanning the fields of materials science, biomedical engineering and biochemical engineering

Readership

Academics and researchers in materials science, nanomedicine, biomedical engineering and chemical engineering. Also of interest to those working in medical diagnostics, both in industry and clinical settings

Table of contents

1. Prospects of fluidic force microscopy and related biosensors for medical applications
Tamás Gerecsei, Beatrix Peter, Rita Ungai-Salánki, Sándor Kurunczi, Inna Sz_ekács, Bálint Szabó, and Robert Horvath

1.1 Atomic force microscopy

1.2 Cell biology with AFM

1.3 Fluidic force microscopy

1.4 Single-cell force spectroscopy by FluidFM

1.5 Bacterial adhesion measured by FluidFM

1.6 Eukaryotic cell adhesion

1.7 Additional fluidic force microscopy functions

1.8 Measurements by computer-controlled micropipette

1.9 Label-free biosensors for cell adhesion analysis

1.10 Summary
Acknowledgments
References

2. Point of care diagnostics for cancer: Recent trends and challenges
Hemani Dara, Mukund Mali, Hrushikesh Aher, PrafullaKumar Patil, Bichismita Sahu, and Neha Arya

2.1 Introduction

2.2 Role of biomarkers in the detection of cancer

2.3 Point-of-care diagnostics for cancer

2.4 Conclusion and future perspectives
Acknowledgments
References

3. Bioelectrochemical methods in biomolecular analysis
Rituparna Addy, Ankit Yadav, Manoj Kumar, Ubhat Ali, Ankenapally Anjali, Vijay Kumar Garlapati, Sudipa Bhadra, and Surajbhan Sevda

3.1 Introduction

3.2 Types of bioelectrochemical methods for bimolecular analysis: Working mechanism

3.3 Application of bioelectrochemical system based biosensor

3.4 Bioelectrochemical methods for cell analysis

3.5 Bioelectrochemical methods for cell analysis

3.6 Bioelectrochemical methods for cell culture fabrication and cell stimulation

3.7 Prospective and future trends References

4. Electrochemical nano-aptasensor as potential diagnostic device for thrombin
Wei Juen Liew, Chitra Padmakumari Kurup, Mohammad Rizwan, and Minhaz Uddin Ahmed

4.1 Introduction

4.2 Aptasensor

4.3 Thrombin

4.4 Application of electrochemical aptasensors in thrombin detection

4.5 Conclusions and future outlook
Conflict of interest
Acknowledgments
References

5. Antibiotics and analytical methods used for their determination
O.I. Guliy, B.D. Zaitsev, and I.A. Borodina

5.1 Introduction

5.2 Antibacterial drugs and the extent of their use

5.3 Conclusion
Acknowledgments
Conflict of interest
References

6. Integration of microfluidics with biosensing technology for noncommunicable disease diagnosis
Syazana Abdullah Lim, Afiqah Nabihah Ahmad, Roslynna Rosli, and Siti Noorfatimah Safar

6.1 Introduction

6.2 Biosensor technology

6.3 Microfluidics technology

6.4 Microfluidics-based biosensors

6.5 Communication technology

6.6 Conclusion
References

7. Role and implication of nanomaterials in clinical diagnostics
Juhi Shah, Stuti Bhagat, and Sanjay Singh

7.1 Introduction

7.2 Nanomaterials in bioimaging based diagnostics

7.3 Nanodevices

7.4 Nano-biosensors

7.5 Lateral flow assay

7.6 Safety concerns and limitations of using nanoparticle

7.7 Conclusion and future prospects
Acknowledgments
References

8. Nano-materials in biochemical analysis
Somu Yadav and Pawan Kumar Maurya

8.1 Introduction

8.2 Classification of nanoparticles

8.3 Synthesis of nanoparticles

8.4 Functionalization of nanomaterials for biochemical applications

8.5 Biochemical applications of nanoparticles

8.6 Conclusion and future prospects
References

9. Lignocellulose-based nanomaterials for diagnostic and therapeutic applications
Hemansi and Jitendra Kumar Saini

9.1 Introduction

9.2 Lignocellulose and its composition

9.3 Nanoparticles from lignocellulose

9.4 Biomedical applications of LCB nanomaterials

9.5 Conclusion and future prospects
References

10. Bioanalytical approaches in detection of free radicals and RONS
Aditya Arya

10.1 Introduction

10.2 Overview of ROS detection methods

10.3 Conventional ex vivo bioanalytical methods

10.4 Conventional in vivo methods

10.5 Advance methods for radical/RNOS detection

10.6 Conclusion
References

11. Nano-biosensors for biochemical analysis
Nimit Shah, Ashish Badiye, Neeti Kapoor, and Ritesh K Shukla

11.1 Introduction

11.2 Biosensors

11.3 AuNP-based biosensors

11.4 Carbon nanotube based biosensors

11.5 Quantum dots based biosensors

11.6 Nanoparticles in analytical biochemistry

11.7 Nanoparticles in bioassays

11.8 Applications

11.9 Conclusion and future perspectives
Acknowledgments
References

12. Nanobiomaterials in biomedicine: Designing approaches and critical concepts
Pallabi Banerjee and Imteyaz Qamar

12.1 Introduction

12.2 Nanomaterials and it’s applications in nanomedicine

12.3 Nanoparticles used in drug delivery system

12.4 Conclusion
References

13. Erythrocytes model for oxidative stress analysis
Vikram Dalal and Sagarika Biswas

13.1 Oxidative stress

13.2 Oxidative stress and diseases

13.3 Oxidative stress and autoimmune diseases

13.4 Oxidative stress and rheumatoid arthritis

13.5 Oxidative stress and erythrocytes

13.6 Conclusion
Acknowledgment
References

14. Lipid film based biosensors: A protection tool for the public health
Georgia-Paraskevi Nikoleli

14.1 Introduction

14.2 Construction of lipid film based nanosensors

14.3 Applications of lipid film based biosensors in clinical analysis for the protection of public health

14.4 Conclusion
References

Product details

  • Edition: 1
  • Latest edition
  • Published: June 21, 2022
  • Language: English

About the editors

PM

Pawan Kumar Maurya

Dr. Pawan Kumar Maurya is a biochemist and Professor in the Department of Biochemistry at the Central University of Haryana, where he also serves as Dean of Academic Affairs. He earned his MSc and PhD in Biochemistry from the University of Allahabad. His research spans oxidative stress, aging, nanomedicine, and clinical biochemistry. He has completed postdoctoral training at several institutions in Asia and Brazil. Dr. Maurya has been honored with national and international awards for his work. He is active in professional societies including the Association of Gerontology India, the Society of Neurochemistry India, and Indian Biochemists’ and Microbiologists’ associations. His scholarly output includes books, book chapters, and numerous research articles. He contributes to technical and organizing committees for national and international conferences. A dedicated educator, he specializes in biochemical diagnostics, nanomedicine, and clinical biochemistry, with a track record of editorial work with major publishers.
Affiliations and expertise
Central University of Haryana, Mahendergarh (Haryana), India

PC

Pranjal Chandra

Dr. Pranjal Chandra earned his Ph.D. from Pusan National University, South Korea and did post-doctoral training at Technion-Israel Institute of Technology, Israel. He has published over 85 research articles in reputed journals and 7 books. He is also a visiting scientist/Professor at IBST, South Korea. Pranjal's research contributions are highly interdisciplinary, spanning a wide range in nanobiotechnology, nanobiosensors, lab-on-chip systems for biomedical diagnostics, and nanomedicine. His work has been highlighted in the World news of Royal Society of Chemistry, Cambridge as "A new system for cancer detection” and also featured as a key scientific article in the Global Medical Discovery news Canada. He is recipient of many prestigious awards and fellowships such as; Ramanujan fellowship and Early Career Research Award (Government of India), BK -21 and NRF fellowship of South Korea, Technion post-doctoral fellowship, Israel, University of Montreal Post-doc fellowship, Canada, NMS Young scientist Award (2016) etc. He is also editorial board member of a dozen international journals including; World journal of methodology, USA; Frontiers of Biosciences, USA; Journal of Biosensors and Bioelectronics, USA etc.
Affiliations and expertise
Assistant Professor and principal investigator, School of Biochemical Engineering Indian Institute of Technology (BHU), Varanasi - Uttar Pradesh 221005, India

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