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Nanomaterials as Gene and Nucleic Acid Delivery Platforms

  • 1st Edition - December 1, 2026
  • Latest edition
  • Editors: Rocktotpal Konwarh, William C.S. Cho
  • Language: English

Nanomaterials as Gene and Nucleic Acid Delivery Platforms explores the intersection between gene therapy and nanotechnology, assessing the benefits of nanoscale platforms for sa… Read more

Description

Nanomaterials as Gene and Nucleic Acid Delivery Platforms explores the intersection between gene therapy and nanotechnology, assessing the benefits of nanoscale platforms for safe and efficient gene and nucleic acid delivery. Sections address the growing need for alternative gene delivery methods to overcome the limitations and safety concerns associated with conventional viral vectors. Four comprehensive parts provide a holistic overview of the core concepts of gene therapy and delivery; the broad range of nanomaterials available for use as carriers; key approaches, and clinical translation of nanomaterial-based delivery platforms for gene therapy.

This book will be of great use to researchers and academics in the fields of nanomaterials, biomaterials, gene therapy, molecular biology, immunology, and disease therapeutics. This book may also be of interest to clinicians researching novel materials and approaches for therapeutics.

Key features

  • Covers the unique and beneficial properties of a wide range of nanomaterials for gene and nucleic acid delivery, including polymers, proteins and peptides, lipids, metals, and carbon-based nanomaterials
  • Reviews applications of nanomaterial-based gene delivery platforms in tissue engineering, regenerative medicine, drug delivery, cancer treatment, and more
  • Details assay approaches and transfection factors for in vitro and in vivo use, as well as clinical translation considerations

Readership

Academics and researchers in the fields of materials science, biomaterials, and genetics

Table of contents

Part 1: Introduction to Nanomaterials in Gene and Nucleic Acid Delivery

1. Nanomaterials: Basics to biocargo-delivery applications

2. Gene therapy: Principles, prospects, and challenges in viral and non-viral gene delivery stratagems

3. Harnessing nanomaterials in gene delivery, gene therapy and genome engineering- Retrospect and prospects

Part 2: Spectrum of Nanomaterials for Gene Delivery

4. Design, diversity and applications of polymeric nanomaterials in gene delivery

5. Dendrimers and nanostructured hyperbranched polymers in gene delivery

6. Proteins and peptide nanomaterials for gene delivery

7. Polysaccharide based nanomaterials for gene delivery

8. Lipid based nanomaterials in gene delivery

9. Harnessing exosomes for gene delivery

10. Metal based nanomaterials in nucleic acid delivery and therapy

11. Carbon and silica-based nanomaterials for gene delivery

12. Quantum dots as multifunctional gene delivery agents

13. Trigger/stimulus-responsive nanomaterials for gene delivery

14. Viruses: Prospects for nanomedicine and gene delivery

Part 3: Approaches and Considerations in Nanomaterials Mediated Gene Delivery

15. Factors affecting in vitro and ex vivo transfection and in vivo gene delivery using nanomaterials

16. Nanomaterials and gene expression profile modulation

17. Assay approaches for in vitro and in vivo gene expression profiling

18. Nanotechnology, omics science and gene therapy

19. Nanomaterials and facets of epigenetics

Part 4: Key Applications and Clinical Translation

20. Plant genome engineering: Prospects of nanomaterials-based gene delivery

21. Gene delivery using electrospun nanobiomaterials: Implications in tissue engineering and regenerative medicine

22. Nanomaterials for siRNA delivery and the gamut of applications

23. Nanomaterials as CRISPR/Cas delivery platforms for genome editing

24. Harnessing nanomaterials in gene therapy for cancer

25. Nanomaterials for neural-specific gene therapy

26. Nanotechnology in gene delivery for ophthalmic applications

27. Ethics, clinical translation and safety regulations of nanomaterials in gene therapy

Product details

  • Edition: 1
  • Latest edition
  • Published: December 1, 2026
  • Language: English

About the editors

RK

Rocktotpal Konwarh

Dr Rocktotpal Konwarh is a Scientist at Baba Kinaram Research Foundation, Mau, India. He completed his PhD in Chemical Sciences from Tezpur University, India, before joining as a DBT Research Associate in Bioinformatics. He was an Institutional Post-Doctoral Fellow in Biomaterial Engineering and Nanomedicine at IIT Guwahati, India. Dr Konwarh has previously been an Assistant Professor at Addis Ababa Science and Technology University, Ethiopia, and a guest faculty member at Dibrugarh University, India, Jimma University, Ethiopia, and Mekelle University, Ethiopia. His research interests include nanomaterials and biopolymeric nanocomposites for biomedical and allied applications, tissue engineering, and targeted therapeutics delivery. He has obtained several research fellowships over the years, including the Canadian Commonwealth visiting research fellowship, University of Guelph, Canada, and the DST-UKIERI project co-investigatorship and post-doctoral visiting research fellowship to University College London, England. Dr Konwarh is an editorial board and review board member of international peer-reviewed journals and author of many highly cited journal articles, as well as a couple of book chapters.

Affiliations and expertise
Scientist, Baba Kinaram Research Foundation, Mau, India

WC

William C.S. Cho

Dr. William C. Cho, Highly Cited Researchers in 2023 by Clarivate. Dr. Cho has published over 600 SCI peer-reviewed papers; he is the world's top 0.1% most influential scientists in the world.

Affiliations and expertise
Queen Elizabeth Hospital, Hong Kong