Nanomaterials for Magnetic and Optical Hyperthermia Applications

Contents

Contributors

Introduction to Hyperthermia

Raluca M. Fratila, Jesús M. de la Fuente

1 Hyperthermia as Therapeutic Approach

2 Hyperthermia at the Nanoscale—Why

Nanomaterials?

3 About This book

4 References

A

PRINCIPLES OF HYPERTHERMIA

1. Design Criteria of Thermal Seeds for Magnetic Fluid Hyperthermia From Magnetic Physics Point of View

Hiroaki Mamiya, Balachandran Jeyadevan

1.1 Introduction

1.2 Mechanism of Heat Generation

1.3 Operational Limits of Magnetic Field and Frequency Conditions

1.4 Novel Responses of Individual Magnetic

Nanoparticles to AC Magnetic Fields

1.5 Potential of Interacting MagneticNanoparticles

1.6 Summary and Perspectives

References

2. Design of Anisotropic Iron-Oxide-Based

Nanoparticles for Magnetic Hyperthermia

Geoffrey Cotin, Francis Perton, Cristina Blanco-Andujar, Benoit Pichon, Damien Mertz, Sylvie Bégin-Colin

2.1 Key Parameters Controlling the Generated Heat

2.2 Optimization of MH Properties of IONPs by Doping or Shape-Controlled Synthesis

2.3 Conclusion

References

3. Synthesis and Characterization of Magnetic–Plasmonic Hybrid Nanoparticles

Mari Takahashi, Ryoichi Kitaura, Priyank Mohan, Shinya Maenosono

3.1 Introduction

3.2 Synthesis and Characterization

3.3 Conclusion

References

4. Noble Metal-Based Plasmonic Nanoparticles for SERS Imaging and Photothermal Therapy

Yulán Hernández, Betty C. Galarreta

4.1 Introduction

4.2 Plasmonic Properties of Metallic Nanoparticles

4.3 Optical Hyperthermia

4.4 Synthesis Methods

4.5 Functionalization

4.6 Theragnostics (SERS + PTT)

4.7 Conclusion

References

Further Reading

5. Instrumentation for Magnetic Hyperthermia

David Cabrera, Irene Rubia-Rodríguez, Eneko Garaio, Fernando Plazaola, Luc Dupré, Neil Farrow, Francisco J. Terán, Daniel Ortega

5.1 Introduction

5.2 Fundamental Aspects of Coil Design for MH

5.3 Temperature Measurement in MH

5.4 Commercial and Noncommercial Instrumentation to Measure SAR

5.5 Conclusions and Perspectives

Acknowledgments

References

6. Nanoscale Thermometry for Hyperthermia Applications

Rafael Piñol, Carlos D.S. Brites, Nuno J. Silva, Luis D. Carlos, Angel Millán

6.1 Introduction

6.2 High Spatial Resolution Thermometry

6.3 Luminescence Thermometry

6.4 Intracellular Thermometry

6.5 Intracellular Thermometry for Hyperthermia Studies

6.6 Conclusions and Perspectives

Acknowledgments

References

Further Reading

7. High-Frequency Magnetic Response and Hyperthermia From Nanoparticles in Cellular Environments

Neil Telling

7.1 Introduction

7.2 Measuring the High-Frequency Magnetic Response of Nanoparticles

7.3 Magnetic Nanoparticles in Cellular Environments

7.4 Summary and Future Perspectives

References

B

CELLULAR RESPONSE TO HEAT

8. Mechanisms of Cell Death Induced by Optical Hyperthermia

Marta Pérez-Hernández

8.1 Introduction

8.2 Types of Cell Death

8.3 Techniques to Determine the Type of Cell Death

8.4 Cell Death Induced by PTT

8.5 Conclusion

References

9. Invertebrate Models for Hyperthermia:

What We Learned From Caenorhabditis elegans and Hydra vulgaris

Maria Moros, Laura Gonzalez-Moragas, Angela Tino, Anna Laromaine, Claudia Tortiglione

9.1 Introduction to Animal Models in Nanoscience

9.2 NP Fate and Status In Vivo

9.3 Biological Effects of Heat

9.4 Biological Effects of NPs

9.5 Methodological Approaches for Tracking NPs Used for Optical and MHT in Hydra and C. elegans

9.6 Conclusions

References

Further Reading

10. Image-Guided Thermal Therapy

Using Magnetic Particle Imaging and

Magnetic Fluid Hyperthermia

Rohan Dhavalikar, Ana C. Bohórquez, Carlos Rinaldi

10.1 Introduction

10.2 Magnetic Fluid Hyperthermia

10.3 Magnetic Particle Imaging

10.4 Applications

10.5 Combined MPI-MFH

10.6 Conclusion

Acknowledgment

References

11. Nanomaterials for Combined Thermo-Chemotherapy of Cancer

Javier Idiago-López, Eduardo Moreno-Antolín, Raluca M. Fratila

11.1 Introduction

11.2 Magnetic Nanoparticle-Based Thermo-Chemotherapy

11.3 Gold Nanoparticles as Thermo-Chemotherapeutic Agents

11.4 Carbon-Based Nanomaterials for Cancer Thermo-Chemotherapy

11.5 Conclusions and Perspectives

Acknowledgment

References

C

FROM BENCH TO

BEDSIDE—NANOMATERIAL

TOXICITY, REGULATORY

ASPECTS AND

CLINICAL PERSPECTIVES

OF MAGNETIC AND OPTICAL

HYPERTHERMIA

12. A Roadmap to the Standardization of In Vivo Magnetic Hyperthermia

Lilianne Beola, Lucía Gutiérrez, Valeria Grazú, Laura Asín

12.1 Introduction

12.2 Nanoparticle Design for MH In Vivo Application

12.3 Nanoparticle Composition

12.4 Magnetic Hyperthermia Conditions Used In Vivo

12.5 Animal Models and Biological Effects

12.6 Limitations and Future Challenges

References

13. Current Good Manufacturing Practices (cGMPs) in the Commercial Development of Nanomaterials for Hyperthermia Applications

Steven J. Oldenburg, Whitney N. Boehm, Karolina Sauerova, Thomas K. Darlington

13.1 Introduction

13.2 Good Manufacturing Practices

13.3 Regulatory Classification of Nanomaterials

13.4 Hyperthermia Products in Various Stages of Development

13.5 Regulatory Strategy for Hyperthermia Products

13.6 Quality Management Systems

13.7 cGMP and Design Controls as a Framework for Project Success

13.8 Conclusion

References

Further Reading

D

CONCLUSIONS AND

PERSPECTIVES

Conclusions: Magnetic and Optical Hyperthermia Using Nanomaterials—Limitations, Challenges and Future

Raluca M. Fratila, Jesús M. de la Fuente

Perspectives

Index