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Elsevier

Nanomaterials for Medical Applications

  • 1st Edition - October 10, 2012
  • Latest edition
  • Author: Zoraida Aguilar
  • Language: English

This title covers recent advances in a variety of biomedical applications of nanostructured materials, as the field evolves from prototype device to real-world application. It pr… Read more

Description

This title covers recent advances in a variety of biomedical applications of nanostructured materials, as the field evolves from prototype device to real-world application. It presents the main types of nanomaterial used in medical application today: semiconductor nanomaterials, Magnetic nanomaterials, metal nanoparticles, Carbon nanomaterials, Hydrogel nanocomposites, Liposomes, Dendrimers, Polymer nanocomposites, and Biodegradable polymers. Structurally the work is demarcated into the six most popular areas of research:(1) biocompatibility of nanomaterials with living organisms in their various manifestations(2) nanobiosensors for clinical diagnostics, detecting biomolecules which are useful in the clinical diagnosis of genetic, metabolically acquired, induced or infectious disease(3) targeted drug delivery for nanomaterials in their various modifications(4) nanomedical devices and structures which are used in the development of implantable medical devices and structures such as nanorobots(5) nanopharmacology, as novel nanoparticles are increasingly engineered to diagnose conditions and recognize pathogens, identify ideal pharmaceutical agents to treat the condition or pathogens, fuel high-yield production of matched pharmaceuticals (potentially in vivo), locate, attach or enter target tissue, structures or pathogens; and dispense the ideal mass of matched biological compound to the target regions(6) nanotoxicology and remediation, which focuses on finished and on-going various toxicity evaluations on various nanomaterials that are used and currently being developed for medical applications.

Key features

  • Discusses the most important biomedical applications and devices of nanomaterials: drug delivery, medical imaging, gene therapy, nanorobots, biosensors and diagnostics
  • Focuses on current commercialized techniques and applications, ensuring the work is entirely relevant to a rapidly evolving field
  • Reviews the most recent studies on nanomaterial toxicity, thereby responding to the widescale private, policy and public interest in nanoscience

Readership

Graduate students and above researching aspects of nanomaterial science, either currently being used or being studied for medical applications, including drug delivery, medical imaging, gene therapy, nanorobots, biosensors, and diagnostics. Nanotech professionals and some policy makers looking for synthesis of existing approaches

Table of contents

ForewordPrefaceAcknowledgements1. Introduction1.1 Nanotechnology Potential Applications and Market Analysis1.2 NMs for Medical Applications1.3 Historical and Future Perspective1.4 The Future of NanotechnologyReferences2. Types of Nanomaterials and Corresponding Methods of Synthesis2.1 Inorganic NMS2.2 Gold and Silver NMS2.3 Organic NMS2.4 Carbon Nanoplatforms2.5 Dendrimers2.6 Characterization of NMS2.7 ConclusionsReferences3. Biocompatibility and Functionalization3.1 Introduction3.2 Nanomaterial Conversion into the Water-Soluble Form3.3 NM Bioconjugation3.4 Applications of Biocompatible NMs3.5 ConclusionsReferences4. Nanobiosensors4.1 Introduction4.2 Nanobiosensors Unique Properties4.3 Immobilization Strategies4.4 Covalent Binding4.5 Self-assembled Monolayers4.6 Quantification of Biomolecules Loaded on NMS4.7 Transduction Detection Systems for NP Biosensors4.8 Applications4.9 An IOMNP-Based ELISA for the Detection of Protein Biomarkers for Cancer4.10 ConclusionsReferences5. Targeted Drug Delivery5.1 Introduction5.2 Nanomaterials as Vehicles for Drug Delivery5.3 Factors to Consider for NPs That will be Used for Drug Delivery5.4 Drug Loading5.5 NM Targeting for Drug Delivery5.6 Binding and Uptake5.7 Drug Release and Biodegradation5.8 NM Clearance5.9 Various NMs for Drug Delivery5.10 The Blood Brain Barrier (BBB)5.11 ConclusionReferences6. Nanomedical Devices6.1 Introduction6.2 Nanorobots6.3 Nanochips and Nanoimplants6.4 Prosthesis6.5 Tissue Engineering6.6 Cell Repair6.7 ConclusionReferences7. Nanopharmacology7.1 Introduction7.2 Current Issues and Status of Nanopharmacology7.3 NMS for Gene Delivery7.4 Nanoimmunotherapy7.5 NMs for Thermal Ablation7.6 NMs as Contrast Agents7.7 Magnetic IO NP-mediated Circulating Tumor Cell Isolation7.8 Design Trends for Individualized Medicine7.9 ConclusionsReferences8. Nanotoxicology and Remediation8.1 Introduction8.2 NMS Exhibiting Toxicity8.3 Handling, Storage, and Disposal of NMS8.4 Remediation in Case of NMS Spills8.5 Nanotoxicity Regulations8.6 The NMS Intellectual Property Perspective8.7 ConclusionReferences9. Conclusions9.1 Introduction9.2 Market Potential9.3 Synthesis of Various NMs9.4 NMs Surface Modification and Functionalization9.5 Nanobiosensors9.6 NMs for Drug Delivery9.7 Nanomedical Devices9.8 Nanopharmacology9.9 Nanotoxicology9.10 Government Nanotoxicity Regulations9.11 Patent LandscapeReferencesIndex

Review quotes

"…this ambitious volume succeeds in highlighting many of the current areas of interest in the field of nanomedicine, and benefits from a multi-disciplinary perspective and a balanced discussion of the many promises of nanomaterials in medicine as well the attendant safety issues. The book is recommended to young scientists entering into this exciting new field."—MaterialsViews.com, February 27, 2014

"Aguilar…presents a broad review of nanomaterials and their application in medicine, from their properties and synthesis to existing and future commercial products."—Reference and Research Book News, February 2013

Product details

  • Edition: 1
  • Latest edition
  • Published: December 31, 2012
  • Language: English

About the author

ZA

Zoraida Aguilar

Zoraida Aguilar is Director of Research and Development at Ocean Nanotech, LLC in Springdale, Arkansas, USA.
Affiliations and expertise
Director of Research and Development, Ocean Nanotech, LLC, Springdale, Arkansas, USA

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