Nanotechnology Applications for Tissue Engineering
- 1st Edition - January 3, 2015
- Latest edition
- Editors: Sabu Thomas, Yves Grohens, Neethu Ninan
- Language: English
Tissue engineering involves seeding of cells on bio-mimicked scaffolds providing adhesive surfaces. Researchers though face a range of problems in generating tissue which can be ci… Read more
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Description
Description
Tissue engineering involves seeding of cells on bio-mimicked scaffolds providing adhesive surfaces. Researchers though face a range of problems in generating tissue which can be circumvented by employing nanotechnology. It provides substrates for cell adhesion and proliferation and agents for cell growth and can be used to create nanostructures and nanoparticles to aid the engineering of different types of tissue.Written by renowned scientists from academia and industry, this book covers the recent developments, trends and innovations in the application of nanotechnologies in tissue engineering and regenerative medicine. It provides information on methodologies for designing and using biomaterials to regenerate tissue, on novel nano-textured surface features of materials (nano-structured polymers and metals e.g.) as well as on theranostics, immunology and nano-toxicology aspects. In the book also explained are fabrication techniques for production of scaffolds to a series of tissue-specific applications of scaffolds in tissue engineering for specific biomaterials and several types of tissue (such as skin bone, cartilage, vascular, cardiac, bladder and brain tissue). Furthermore, developments in nano drug delivery, gene therapy and cancer nanotechonology are described.The book helps readers to gain a working knowledge about the nanotechnology aspects of tissue engineering and will be of great use to those involved in building specific tissue substitutes in reaching their objective in a more efficient way. It is aimed for R&D and academic scientists, lab engineers, lecturers and PhD students engaged in the fields of tissue engineering or more generally regenerative medicine, nanomedicine, medical devices, nanofabrication, biofabrication, nano- and biomaterials and biomedical engineering.
Key features
Key features
- Provides state-of-the-art knowledge on how nanotechnology can help tackling known problems in tissue engineering
- Covers materials design, fabrication techniques for tissue-specific applications as well as immunology and toxicology aspects
- Helps scientists and lab engineers building tissue substitutes in a more efficient way
Readership
Readership
Scientists, engineers, lecturers and PhD students engaged in the fields of tissue engineering, regenerative medicine, nanomedicine, nanofabrication, biofabrication and biomedical engineering. Physicians and medical students/researchers
Table of contents
Table of contents
Chapter 1. Nanomedicine and Tissue Engineering
- 1.1 Introduction
- 1.2 Relationship of Nanomedicine and Tissue Engineering
- 1.3 Nanodrug Delivery Systems for Tissue Regeneration
- 1.4 Medical Applications of Molecular Nanotechnology
- 1.5 Summary and Future Directions
- References
Chapter 2. Biomaterials: Design, Development and Biomedical Applications
- 2.1 Overview
- 2.2 Design of Biomaterials
- 2.3 Basic Considerations to Design Biomaterial
- 2.4 Characteristics of Biomaterials
- 2.5 Fundamental Aspects of Tissue Responses to Biomaterials
- 2.6 Evaluation of Biomaterial Behavior
- 2.7 Properties of Biomaterials Assessed Through In Vivo Experiments
- 2.8 Applications of Biomaterials
- 2.9 Future Directions in Biomaterials
- 2.10 Conclusions
- Acknowledgments
- References
Chapter 3. Electrospinning of Polymers for Tissue Engineering
- 3.1 Introduction
- 3.2 History of Electrospinning
- 3.3 Experimental Setup and Basic Principle
- 3.4 Effects of Parameters on Electrospinning
- 3.5 Biomedical Applications of Electrospun Nanofibers
- 3.6 Conclusion
- Acknowledgments
- References
Chapter 4. Biomimetic Nanofibers for Musculoskeletal Tissue Engineering
- 4.1 Structural and Functional Requirements for Musculoskeletal Tissues
- 4.2 Nanofibers as 3D Scaffolds for Tissue Regeneration
- 4.3 Extracellular Matrix Analogs for Cartilage Regeneration
- 4.4 Bioactive Nanofibers and Methods of Immobilizing Biomolecules
- 4.5 Gene Delivery Through Nanofibers
- 4.6 Techniques to Improve Porosity and Cell Infiltration on Nanofiber Scaffolds
- 4.7 Nanofiber Scaffolds for Interface Regeneration
- 4.8 Conclusion
- References
Chapter 5. Hydrogels—Promising Candidates for Tissue Engineering
- 5.1 Introduction
- 5.2 Polymer
- 5.3 Hydrogel
- 5.4 Different Types of Hydrogels Used in TE
- 5.5 Conclusion
- References
Chapter 6. 3D Scaffolding for Pancreatic Islet Replacement
- 6.1 Introduction
- 6.2 Oxygenation—Prime Factor for Islet Survival
- 6.3 Conclusion
- Acknowledgments
- References
Chapter 7. Scaffolds with Antibacterial Properties
- 7.1 Introduction
- 7.2 Nanoparticles Incorporated Antibacterial Scaffolds
- 7.3 Antibiotics-Loaded Tissue Engineering Scaffolds
- 7.4 Conclusion
- Acknowledgments
- References
Chapter 8. Dermal Tissue Engineering: Current Trends
- 8.1 Introduction
- 8.2 Nanotopography-Guided Skin Tissue Engineering
- 8.3 Stem Cells for Skin Tissue Engineering
- 8.4 Scarless Fetal Skin Wound Healing
- 8.5 Conclusion
- Acknowledgment
- References
Chapter 9. Chitosan and Its Application as Tissue Engineering Scaffolds
- 9.1 Introduction
- 9.2 Chitosan as Biomaterial for Tissue Engineering Scaffold
- 9.3 Biomedical Applications
- 9.4 Conclusion
- Acknowledgment
- References
Chapter 10. Cell Encapsulation in Polymeric Self-Assembled Hydrogels
- 10.1 Overview
- 10.2 Preparation of Self-Assembled Hydrogels
- 10.3 Hydrogels Characteristics for Cells
- 10.4 Self-Assembled Hydrogels
- 10.5 Significance of Natural and Synthetic Polymer for Hydrogels
- 10.6 Recent Development of Self-Assembled Hydrogels
- 10.7 Future Trends
- 10.8 Conclusions
- Acknowledgments
- References
Chapter 11. Nanotechnology-Enabled Drug Delivery for Cancer Therapy
- 11.1 Cancer
- 11.2 Mutation of Gene
- 11.3 Nanotechnology and Its Application
- 11.4 Cancer Detection and Diagnosis
- 11.5 Pharmaceutical Nanotechnology
- 11.6 Conclusion
- Acknowledgment
- References
Chapter 12. Nanomedicine in Theranostics
- 12.1 Introduction
- 12.2 Nanotheranostics—A New Concept of Nanomedicine
- 12.3 Design of Theranostic Agents
- 12.4 Diagnosis Through Nanoparticle Imaging
- 12.5 Therapy in Nanotheranostics—Drugs
- 12.6 Carriers of the Nanotheranostic System
- 12.7 Theranostic Applications—the Current Situation
- 12.8 Future Perspectives of Nanotheranostics
- 12.9 Conclusion
- References
Chapter 13. Upconversion Nanoparticles
- 13.1 Introduction
- 13.2 Properties of UCNPs
- 13.3 Applications in Drug Delivery
- 13.4 Applications in Biological Imaging
- 13.5 Applications in Biological Detection
- 13.6 Conclusion and Future Outlook
- Acknowledgments
- References
Chapter 14. Gold Nanoparticles in Cancer Drug Delivery
- 14.1 Introduction
- 14.2 Cancer Nanotechnology
- 14.3 Gold Nanoparticles
- 14.4 Conclusion
- References
Chapter 15. Toxicology Considerations in Nanomedicine
- 15.1 Introduction
- 15.2 The Market Potential of Nanomedicines
- 15.3 Toxicity Associated with Nanomedicine
- 15.4 Factors Affecting Nanomedicine Toxicity
- 15.5 Toxicological Testing
- 15.6 Conclusion
- References
Chapter 16. Role of Nanogenotoxicology Studies in Safety Evaluation of Nanomaterials
- 16.1 Introduction
- 16.2 Influence of the NMs’ Properties on their Biological Interactions
- 16.3 A Conceptual Framework for Toxicological Investigation in Nanomedicine
- 16.4 Nanogenotoxicology—An Essential Contribution for NMs Safety Assessment
- 16.5 State of the Art on Genotoxicity of NMs with Potential Interest for Scaffolds Fabrication
- 16.6 Future Directions in the Genotoxicity Evaluation of NMs for Tissue Engineering
- 16.7 Conclusions
- Acknowledgments
- References
Chapter 17. Future of Nanotechnology in Tissue Engineering
- 17.1 Introduction
- 17.2 Conclusion and Future Outlook
- References
Product details
Product details
- Edition: 1
- Latest edition
- Published: January 8, 2015
- Language: English
About the editors
About the editors
ST
Sabu Thomas
Sabu Thomas is a Professor and Director of the International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kerala, India. Professor Thomas is internationally recognized for his contributions to polymer science and engineering, with his research interests encompassing polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites, nanocomposites, nanomedicine, and green nanotechnology. His groundbreaking inventions in polymer nanocomposites, polymer blends, green bionanotechnology, and nano-biomedical sciences have significantly advanced the development of new materials for the automotive, space, housing, and biomedical fields.
YG
Yves Grohens
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