Neurogenic Heart Lesions

Foreword

Introduction

Chapter I: Methods for Producing Experimental Neurogenic Lesions

Structural Myocardial Lesions Produced by Electrical Stimulation of the Hypothalamus

Ultrastructural and Microscopic Changes Produced by Reflex Lesions of the Myocardium

Pharmacological and Physiological Analysis of the Propagation Paths of the Impulses Producing Neurogenic Lesions of the Heart

Chapter II: Pharmacological Analysis of the Participation of the Sympathetic Nervous System and its Transmitters in the Mechanism of Development of Neurogenic Lesions of the Myocardium

Noradrenaline Levels in Myocardial Tissue during Excessive Stimulation

Experiments with the Precursor of Noradrenaline — L-Dopa

Experiments with the Central α-Adrenoblocker, IEM-611

Experiments with Ethymisol

Experiments with the Ganglioblocker, Benzohexamethonium

Experiments with the β-Blocker, Propranolol

Experiments with Toxic Doses of Catecholamines

Chapter III: Changes in Energy Metabolism and in Functional Conditions of the Myocardium Caused by Neurogenic Lesions

Glycogen Levels and the Process of Glycolysis during Excessive Stimulation of the Animals

Oxidative Phosphorylation in the Mitochondria of the Heart Produced by its Neurogenic Lesion and the Injection of Toxic Doses of Noradrenaline

High-Energy ATP and CP and Inorganic Phosphorus (IP) Levels in the Myocardium Produced by Excessive Stimulation

The Activity of the First Stage of the Pentose-Phosphate Pathway — Glucose-6-Phosphate Dehydrogenase

Electrocardiographic Data Obtained during Neurogenic Lesions of the Myocardium and the Injection of Large Doses of Noradrenaline

Chapter IV: Pharmacoprophylaxis and Pharmacotherapy of the Biochemical Changes Produced by Neurogenic Lesions of the Myocardium

Experiments with the Precursor of Noradrenaline, L-Dopa

Experiments with Ethymisol

Experiments with the Central α-Adrenoblocker, IEM-611

Experiments with the Ganglioblocker, Benzohexamethonium

Experiments with the β-Blocker, Propranolol

Chapter V: The Analysis of Experimental and Clinical Data

References

Index