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Elsevier

Neuromuscular Junction Disorders

  • 1st Edition, Volume 91 - August 4, 2008
  • Latest edition
  • Editor: A. G. Engel
  • Language: English

This volume provides concise and comprehensive information on neuromuscular disorders, including rapid advancements in the understanding of the neurobiology of neuromuscular tr… Read more

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Description

This volume provides concise and comprehensive information on neuromuscular disorders, including rapid advancements in the understanding of the neurobiology of neuromuscular transmission. In addition, clinicians will find timely discussions on the various forms of these disorders that have been discovered due to increased study within the field.

New observations into the immunopathogenesis of myasthenia gravis, and the molecular mechanisms underlying the links between activity and patterns of gene expression, particularly in muscle, are also explored, along with novel information on the understanding of the pathophysiology of the heterogeneous group of peripheral nerve hyperexcitability syndromes.

Each of these valuable insights, and their accompanying explanations, provides a framework on which new therapeutic strategies can be built to aid in the enhancement and restoration of normal function in neuromuscular junction disorders.

Key features

  • New insights into the study of neuromuscular junction disorders, including rapid advancements in the field
  • Comprehensive information on the neuromuscular junction, and a detailed examination of myasthenia gravis and other disorders
  • A new framework upon which to build therapeutic strategies that will enhance the restoration of normal function in neuromuscular disorders

Readership

Neurologists
Neuroscience research workers

Table of contents

The most vulnerable synapse: historic aspects of neuromuscular junction disorders. Reliability of neuromuscular transmission and how it is maintained. The neuromuscular junction. Electromyographic aspects of neuromuscular junction disorders. The immunopathogenesis of myasthenia gravis. Autoantibodies in different forms of myasthenia gravis and in the Lambert-Eaton syndrome. Clinical features of myasthenia gravis. Therapy of myasthenia gravis. The Lambert-Eaton myasthenic syndrome. Congenital myasthenic syndromes. Botulism. Neurotoxicology of neuromuscular transmission. Organophosphate and carbamate poisoning. Peripheral nerve hyperexcitability and the neuromuscular junction.

Review quotes

This volume, edited by a world-known muscular and written by an international panel of experts, contains 14 chapters dealing with all relevant aspects of disorders of neuromuscular junction. All chapters are clearly written, extensive and instructive, with many subheadings, schemes and figures, providing an excellent and up-to-date overview of the disorders related to neuromuscular junction. Together with extensive reference lists at the end of each chapter, this volume represents an excellent documentation of the state-of-the-art in this complicated and rapidly progressing field of basic and clinical neurosciences.

K.A. Jellinger, The European Journal of Neurology, November 2008

Product details

  • Edition: 1
  • Latest edition
  • Volume: 91
  • Published: October 8, 2008
  • Language: English

About the editor

AE

A. G. Engel

Affiliations and expertise
William L McKnight Professor of Neuroscience, Mayo Clinic College of Medicine; Director, Neuromuscular Disease Research Laboraotry; Consultant Department of Neurology, Mayo Clinic, Rochester, MN, USA

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