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Elsevier

Novel Concepts in iPSC Disease Modeling

  • 1st Edition, Volume 15 - January 8, 2022
  • Latest edition
  • Editor: Alexander Birbrair
  • Language: English

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel… Read more

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Description

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.

iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases.

Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson’s disease, macular degeneration of the retina and much more.

The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.

Key features

  • Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics
  • Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson’s disease, graft vs. host disease, and much more
  • Contributed by world-renown experts in the field

Readership

Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields

Table of contents

1. Induced Pluripotent Stem Cells: Novel Concepts for Respiratory Disease Modelling

2. iPSC For Modeling of Metabolic and Neurodegenerative Disorders

3. iPSCs for Modeling Open-Angle Glaucoma

4. Patient-Specific Induced Pluripotent Stem Cells for Modeling Amyloid Disease

5. iPSCs for Modeling Choroideremia

6. Applications of human hiPSC and hESC for modeling substance use disorders: Addiction and neurodevelopmental toxicity

7. iPSCs for Modeling Cardiac Sodium Channelopathies

8. iPSCs for Modeling Danon Disease

9. Human induced pluripotent stem cells for Modeling of Niemann-Pick Disease type C1

10. iPSC-based Modeling in Psychiatric Disorders: Opportunities and Challenges

11. Research Applications of iPSCs for Modeling of Spinal Cord Injury

12. iPSCs for Modeling Smith-Magenis Syndrome

Product details

  • Edition: 1
  • Latest edition
  • Volume: 15
  • Published: January 8, 2022
  • Language: English

About the editor

AB

Alexander Birbrair

Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Department of Radiology, Columbia University Medical Center, Medical Center, USA

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