Organisation of Chromosomes

Preface

Chapter One. Large Tandem Repeats Make up the Chromosome Bar Code: A Hypothesis

1 Introduction

2 Satellite DNA in the Mouse Genome

3 Tandem Repeat Position Defined by FISH

4 “Bar Code” Hypothesis

Chapter Two. Mammalian Satellite DNA: A Speaking Dumb

1 Introduction

2 Heterochromatin Criteria

3 The Constitutive HC DNA

4 Transcription of HC DNA

5 Functions of Centromeric and Pericentromeric HC DNA Transcription

6 Conclusions

Chapter Three. Zinc Finger Proteins and the 3D Organization of Chromosomes

1 The 3D Organization of the Genome and Loops

2 CTCF and its Role in the 3D Genome Organization

3 A Model for CTCF

4 A Model for CTCF Binding

5 A Method to Compute Similarity for Unstructured Proteins

6 Discussion and Outlook

Chapter Four. Dynamics of Modeled Oligonucleosomes and the Role of Histone Variant Proteins in Nucleosome Organization

1 Introduction

2 Role of H2A.Z in the Dynamics of Modeled Oligonucleosomes

3 Conclusions and Outlook

Chapter Five. Unconventional Actin Configurations Step into the Limelight

1 Introduction

2 Structural Organization of Actin

3 Tools to Study Actin Localization, Arrangement, and Conformation

4 There is More Than F- and G-Actin in Eukaryotic Cells

5 Unconventional Actin Contacts

6 Conclusion

Chapter Six. Chromatin Reorganization Through Mitosis

1 Packaging the Genome

2 The Mitotic Chromosome

3 Specialized Mitotic Chromatin

4 Gene Bookmarking

5 Going Back to Interphase: Chromosome Decondensation

Author Index

Subject Index