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Oxidative Stress

Its Mechanisms and Impacts on Human Health and Disease Onset

  • 1st Edition - October 23, 2022
  • Latest edition
  • Author: Harold Zeliger
  • Language: English

Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation… Read more

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Description

Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation. Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset.

With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.

Key features

  • Covers the chemical exposures and environmental factors that cause oxidative stress
  • Provides further understanding on the mechanisms of oxidative damage response and disease
  • Shows how oxidative stress and its role can be determined non-invasively via the Oxidative Stress Index

Readership

Researchers, toxicologists-particularly those engaged in mechanistic research, clinicians, academics, public health officials; industrial hygienists, chemical manufacturers and those responsible for workplace safety

Table of contents

Dedication
Preface

I. OXIDATIVE STRESS AND DISEASE

1. Introduction

2. Chemicals and chemical mixtures

3. Particles and fibers

4. Air pollution

5. Water and soil pollution

6. Alcohol

7. Tobacco

8. Electromagnetic Radiation

9. Inflammation

10. Food

11. Sleep deprivation

12. Pharmaceuticals

13. Psychological stress

14. Genetics and epigenetics

15. Aging

16. Diseases and co-morbidities

17. Total oxidative stress and disease

18. Free radicals

II. MECHANISMS OF OXIDATIVE STRESS DRIVEN DISEASE

19. Aging mechanism

20. Obesity

21. Cancer

22. Atherosclerosis

23. Alzheimer’s disease

24. Type 2 diabetes

25. Rheumatoid arthritis

26. Asthma

27. Liver cirrhosis

28. Chronic kidney disease

29. Co-morbidities

III. DISEASE ONSET PREDICTION

30. Oxidative stress index

31. Condensed oxidative stress index

32. Oxidative stress index and Alzheimer’s disease

33. Oxidative stress index and public health surveys

34. Oxidative stress index and predicting COVID-19 severity
IV. PREVENTION

35. Lowering oxidative stress

36. Global warming and disease

Review quotes

"This descriptively titled book reviews the importance of oxidative stress and its role in health and disease,...examin[ing] the importance and environmental consequences of oxidative stress to a great extent....[and] useful to the forensic toxicology community and related fields. [It's] extensively referenced and will serve as a useful summary of oxidative stress."—©Doody’s Review Service, 2023, John T. Pierce, MBBS (MD) PhD (Navy Environmental Health Center)

Product details

  • Edition: 1
  • Latest edition
  • Published: October 26, 2022
  • Language: English

About the author

HZ

Harold Zeliger

Dr. Harold I. Zeliger holds a PhD in organic chemistry and has been a professor of chemistry and environmental science. He is a Certified Professional Chemist, a Board- Certified Forensic Examiner, and an EPA Certified Laboratory Director. Dr. Zeliger is the author of 51 technical publications, including basic research journal articles and patents. In his more than 40 years in the Chemical Process Industry, he has personally developed many industrial and consumer chemical products, designed chemical product warning labels and written Material Safety Data Sheets for toxic and flammable chemicals. Dr. Zeliger has investigated hundreds of toxic chemical exposures, environmental spills and discharges, chemical fires and explosions nationally and internationally. He has served repeatedly as an expert witness for both plaintiffs and defendants in chemical product, process, toxic exposure, environmental, flammable, intellectual property and subrogation claims. Dr. Zeliger has provided services for numerous forensic examinations, technology transfer and due diligence investigations. Dr. Zeliger’s research is in the area of chemical toxicology. His published work includes papers on the toxic effects of chemical mixtures and chemical causes of cancer clusters and two editions of Human Toxicology of Chemical Mixtures, Second Edition.
Affiliations and expertise
Toxic and Flammable Chemical Consultant and Expert Witness; Certified Professional Chemist and Board Certified Forensic Examiner; Technology Transfer and Due Diligence Investigator, USA

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