PACAP

From Discovery to Function

1st book:metaData.edition - September 1, 2026
book:metaData.latestEdition
common:contributors.editors David Vaudry, Hitoshi Hashimoto
publicationLanguages:language

PACAP: From Discovery to Function in Health and Disease serves as a comprehensive review covering all aspects of PACAP and its receptors, from expression to function in health… seeMoreDescription

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PACAP: From Discovery to Function in Health and Disease serves as a comprehensive review covering all aspects of PACAP and its receptors, from expression to function in healthy tissues and disease models. The book introduces the biochemical, pharmacological and signaling properties of PACAP before exploring the biological actions of PACAP in normal health and pathological conditions. It considers PACAP in relation to various aspects, including pain, stress, brain injury, tumor cells and neurodegenerative disease. Effect on peripheral organs is also covered, from the gastrointestinal tract and cardiovascular system to immune cells and bones, among others. Therapeutic potential is also explored. This is a volume in the Molecular Mediators in Health and Disease book series, and provides a complete analysis of PACAP and the latest research in the field. Thus it is an ideal guide for researchers interested in PACAP and its impact across health and disease.

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Provides a comprehensive overview of PACAP from a molecular, biochemical and pharmacological standpoint
Covers the effects of PACAP across a range of peripheral organs including the eye, liver, and respiratory system
Explores PACAP in the context of various conditions including neurodegenerative diseases and psychiatric disorders

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Biological and biomedical sciences researchers at PhD level and above

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I. Introduction

II. Pituitary adenylate cyclase-activating polypeptide

1. Discovery and biochemical properties of PACAP (Secondary structure of PACAP, Structure of the PACAP precursor and post-translational processing)

2. Cloning and phylogenetic evolution of the PACAP gene

3. Development of PACAP peptidic analogs for structure-activity characterization

4. Development of PACAP small molecule agonists / antagonists for therapeutic applications III. PACAP receptors

5. Pharmacological, Biochemical and Signaling characterization of PACAP receptors

6. Cloning and phylogenetic evolution of PACAP receptors IV. Expression of PACAP and its receptors

7. Distribution of PACAP and its receptors in the central nervous system (at adulthood and during development)

8. Distribution of PACAP and its receptors in peripheral organs (at adulthood and during development)

9. Presence of PACAP in biological fluids

10. Expression and functional implication of PACAP and its receptors in tumor cells V. Biological actions of PACAP in normal and pathological conditions A. Actions of the CNS

11. Actions on the hypothalamus

12. Actions of PACAP on the pineal gland and circadian rhythms

13. Actions on glial cells

14. Effects of PACAP on the pituitary gland

15. PACAP transport across the BBB and therapeutic implication

16. Neurotrophic actions during development and protective effects in acute brain injuries (stroke and spinal cord)

17. Protective effect of PACAP in neurodegenerative diseases

18. PACAP in migraine

19. Action of PACAP in the central regulation of energy homeostasis, including food intake

20. Behavioral actions of PACAP

21. PACAP and stress

22. PACAP and pain

23. PACAP and psychiatric disorders B. Actions on peripheral organs

24. Effects of PACAP on the eye

25. Effects of PACAP on the thyroid gland

26. Effects of PACAP on the gonads

27. Effects of PACAP on the adrenal gland

28. Effects of PACAP on the gastrointestinal tract

29. Effects of PACAP on the liver

30. Effects of PACAP on the pancreas

31. Effects of PACAP on the respiratory system

32. Effects of PACAP on the cardiovascular system

33. Effects of PACAP on immune cells

34. Effects of PACAP on bones

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productDetails.edition: 1
book:metaData.latestEdition
productDetails.published: September 1, 2026
publicationLanguages:languageTitle: publicationLanguages:en

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David Vaudry

David Vaudry specialises in cell biology and neuroscience. After completing his PhD in 2000, he went on to post-doc training in the laboratory of Dr Lee E. Eiden. Since 2002 he has been a researcher at INSERM, France, where, from 2008-2021 he has led the research team centred on ‘Neuropeptides, Neuronal Death and Cell Plasticity’. Since 2020 he has been Editor in Chief of the journal Neuroendocrinology. He is the author of 187 original articles, books and book chapters referenced in PubMed. He has supervised 14 PhD students and is known internationally for his work on the neurotrophic and neuroprotective effects of PACAP.

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Institut National de la Santé et de la Recherche Médicale (INSERM), France

Hitoshi Hashimoto

Hitoshi Hashimoto received physiological chemistry training and holds a PhD from Kyoto University. In 1991, he became Assistant Professor at Osaka University, and since 2010 he has been a Professor and Chair of the Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University. He is the author of 248 original articles referenced in PubMed. He is one of the leading researchers known for research on the role of PACAP in the brain, particularly in psychiatric disorders, and has recently widened his research area to investigate neurological mechanisms using a whole-brain imaging system, block-FAce Serial microscopy Tomography (FAST) and an array of neuroscience methods.