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Personalized Epigenetics

  • 2nd Edition - July 17, 2024
  • Latest edition
  • Editor: Trygve Tollefsbol
  • Language: English

Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigeneti… Read more

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Description

Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.

Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

Key features

  • Includes new chapters on topics such as the limitations of personalized epigenetic variation comparisons; personalized epigenetics technologies; epigenetics of personalized nanomedicine; personalized epigenetic management of diabetes; epigenetics and chemoresistance; and personalized epigenetics and neurological disorders
  • Covers key methodological processes that are important in personalized medicine
  • Offers disease research case studies to provide in-depth discussion of examples of recent epigenetic research on a disease area
  • Features topics such as forensic epigenetics, epigenetics of personalized toxicity, limitations of epigenetic variation comparisons, and nanomedicine and nutrigenomics as applied to personalized epigenetics

Readership

University researchers, health care professionals, graduate students and post graduates studying life sciences, genetic and/or human diseases, particularly the epigenetics-healthcare relationship as well as pharmaceutical and biotechnology companies interested in drug development

Table of contents

Section I. Overview

1. Epigenetics of Personalized Medicine

Section II. Epigenetic variations Among Individuals

2. Interindividual Variability of DNA Methylation

3. Differences in Histone Modifications Between Individuals

4. Individual Noncoding RNA Variations

5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation

6. Limitations of Personalized Epigenetic Variation Comparisons

Section III. Technologies for Personalized Epigenetics

7. Personalized Epigenetics Technologies

8. Computational Methods in Epigenetics

Section IV. Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine

9. Epigenetic Biomarkers in Personalized Medicine

10. Epigenetic ‘Fingerprint’

11. Epigenetics of Personalized Toxicology

Section V. Environmental Personalized Epigenetics

12. Environmental Contaminants and Their Relationship to the Epigenome

13. Nutriepigenomics: Personalized Nutrition Meets Epigenetics

Section VI. Pharmacology and Drug Development of Personalized Epigenetics

14. Personalized Pharmacoepigenomics

15. Epigenetics of Personalized Nanomedicine

16. Personalized Medicine and Epigenetic Drug Development

Section VII. Personalized Epigenetics of Disorders and Disease Management

17. Understanding Interindividual Epigenetic Variations in Obesity and Its Management

18. Personalized Epigenetic Management of Diabetes

19. Epigenetics and Personalized Pain Management

20. Epigenetic Modification of miRNAs in Cancer

21. Epigenetics and Chemoresistance: A Personalized Approach to Cancer Therapy

22. Personalized Epigenetics and Neurological Disorders

23. Managing Autoimmune Disorders through Personalized Epigenetic Approaches

24. Cardiovascular Diseases and Personalized Epigenetics

Section VIII. Challenges and Future Directions

25. Future Challenges and Prospects for Personalized Epigenetics

Product details

  • Edition: 2
  • Latest edition
  • Published: July 17, 2024
  • Language: English

About the editor

TT

Trygve Tollefsbol

Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Affiliations and expertise
Professor of Biology Senior Scientist, Comprehensive Cancer Center Senior Scientist, Comprehensive Center for Healthy Aging Senior Scientist, Comprehensive Diabetes Center Senior Scientist, Nutrition Obesity Research Center Director, Cell Senescence Culture Facility University of Alabama at Birmingham, AL, USA

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