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Pharmacoepigenetics

Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of t… Read more

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Description

Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development.

Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.

Key features

  • Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development
  • Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry
  • Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety
  • Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Readership

Translational researchers, clinicians and graduate students in genomic medicine, epigenetics; life science researchers; developmental biologists; MDs/clinicians; pharmacologists in industry and academia; cardiologists, psychiatrists, oncologists, hospitalists, primary care doctors, neurologists, immunologists, medical chemists, molecular biologists

Table of contents

1. The Epigenetic Machinery in the Life Cycle and Pharmacoepigenetics

2. Pharmacoepigenetics: Basic Principles for Personalized Medicine

3. Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport

4. MicroRNA-Dependent Gene Regulation of the Human Cytochromes P450

5. Pathoepigenetics: The Role of Epigenetic Biomarkers in Disease Pathogenesis

6. Pharmacoepigenetic Processors: Epigenetic Drugs, Drug Resistance, Toxicoepigenetics, and Nutriepigenetics

7. Pharmacoepigenetics of Novel Nucleoside DNA Methyltransferase Inhibitors

8. Pharmacoepigenetics: Novel Mechanistic Insights in Drug Discovery and Development Targeting Chromatin-Modifying Enzymes

9. Pharmacoepigenetics of EZH2 Inhibitors

10. Regulators of Histone Acetylation: Bromodomain Inhibitors

11. Bromodomain Inhibition and Its Application to Human Disease

12. Epigenetic Drug Discovery for Cancer

13. Pharmacoepigenetics of Histone Deacetylase Inhibitors in Cancer

14. Pharmacoepigenetics of LSD1 Inhibitors in Cancer

15. Pharmacoepigenetic Considerations for the Treatment of Breast Cancer

16. Pharmacoepigenetics of Acute Myeloid Leukemia

17. Therapeutic Potential of Pharmacoepigenetics in Cholangiocarcinoma

18. Pharmacoepigenetics in Type 2 Diabetes Mellitus

19. Pharmacoepigenetics of Immunological Disorders

20. Pharmacoepigenetics of Rheumatic Disorders

21. Pharmacoepigenetics of Systemic Lupus Erythematosus

22. Epigenetics and Pharmacoepigenetics of Neurodevelopmental and Neuropsychiatric Disorders

23. Pharmacoepigenetics and Toxicoepigenetics in Neurodevelopmental Disorders

24. Pharmacoepigenetics of Autism Spectrum Disorder

25. Pharmacoepigenetics of Antipsychotic Drugs

26. Pharmacoepigenetics of Bipolar Disorder

27. Pharmacoepigenetics of Major Depression

28. Pharmacoepigenetics of Vertigo and Related Vestibular Syndromes

29. Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity

30. Pharmacoepigenetics and Pharmacoepigenomics of Valproate in Neurodegenerative Disease

31. Pharmacoepigenetics of Statins

32. Pharmacoepigenetics of Memantine in Dementia

33. Epigenetics in Doxorubicin Cardiotoxicity

34. Pharmacoepigenetics of Brassica-Derived Compounds

35. Pharmacoepigenetics of Chinese Herbal Components in Cancer

36. Epigenetics of Aging and Age-Related Disorders

37. Epigenetics of Aging and Cancer: A Comprehensive Look

38. Epigenetics and Pharmacoepigenetics of Age-Related Neurodegenerative Disorders

Product details

About the editor

RC

Ramón Cacabelos

Dr. Ramón Cacabelos is Professor and Chairman of Genomic Medicine and President of the EuroEspes Biomedical Research Center, Corunna, Spain. He received his M.D. from Oviedo University, Oviedo, Spain; Ph.D. from Santiago University, Santiago de Compostela, Spain; and D.M.Sci. (Psychiatry) from Osaka University Medical School, Osaka, Japan. After a decade at the Department of Psychiatry in Osaka, he returned to Spain and focused his research activity on the genomics, epigenomics and pharmacogenomics of brain disorders, with special emphasis on neurodegenerative disorders (Alzheimer’s disease, Parkinson’s disease). He has published over 700 papers and 30 books and is Editor-in-Chief of the first World Guide for Drug Use and Pharmacogenomics and President of the World Association of Genomic Medicine.
Affiliations and expertise
Professor of Genomic Medicine, Visiting Professor of Health Science, Aino University, Osaka, Japan, President, World Association of Genomic Medicine, President, Spanish Society of Genomic Medicine

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