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Posttraumatic Epilepsy

Basic and Clinical Aspects

  • 1st Edition - October 21, 2022
  • Latest edition
  • Authors: Carrie R. Jonak, Allison R. Peterson, Devin K. Binder
  • Language: English

Posttraumatic Epilepsy: Basic and Clinical Aspects provides a synthesized resource on the recent basic and clinical science developments in the field of posttraumatic epilepsy.… Read more

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Description

Posttraumatic Epilepsy: Basic and Clinical Aspects provides a synthesized resource on the recent basic and clinical science developments in the field of posttraumatic epilepsy. This book provides a clear understanding of the history of studies and epidemiology of posttraumatic epilepsy after head injury. The book also considers the neuropathology of posttraumatic epilepsy and clinical trials of antiepileptogenic agents evaluated after traumatic brain injury. The book covers the basic science of animal models of traumatic brain injury and the necessary and sufficient changes that must occur to generate epilepsy after head trauma. The authors explore potential mechanisms and novel therapeutic approaches to prevent posttraumatic epilepsy. The book is written for basic and clinical researchers in neuroscience as well as for clinicians treating patients with epilepsy.

Key features

  • Reviews the history and epidemiology of posttraumatic epilepsy
  • Considers the neuropathology of posttraumatic epilepsy
  • Synthesizes studies demonstrating risk factors for susceptibility to epilepsy after head trauma
  • Reviews animal models of traumatic brain injury
  • Addresses our current understanding of mechanisms of posttraumatic epilepsy
  • Explores novel therapeutic approaches to prevent posttraumatic epilepsy

Readership

Researchers and clinicians in the fields of neuroscience, neurology, neurotrauma, and neurosurgery. Advanced graduate students in neuroscience, neurology and neurosurgery, as well as military scientists and doctors involved with treading soldiers with traumatic brain injury, and pharmaceutical companies

Table of contents

1. History of posttraumatic epilepsy

2. Epidemiology of posttraumatic epilepsy

3. Neuropathology of posttraumatic epilepsy

4. Clinical trials of agents to prevent posttraumatic epilepsy

5. Surgical treatment of posttraumatic epilepsy

6. Animal models of traumatic brain injury

7. Incidence of posttraumatic epilepsy in animal models of traumatic brain injury

8. Cellular and molecular changes in animal models of posttraumatic epilepsy

9. Blood-brain barrier disruption and posttraumatic epilepsy

10. Inflammation and posttraumatic epilepsy

11. Biomarkers and treatment trials in animal models to prevent posttraumatic epilepsy

12. Therapeutic targets and future directions

Review quotes

"With this comprehensive summary of the important animal model studies to date, the authors demonstrate that continued PTE research in humans is essential. It is crucial to know how to optimize PTE animal models and conduct detailed electrophysiological, cellular, and molecular analyses of PTE versus non-PTE brains in humans. Such future studies will help to identify more selective and precise therapies to treat PTE. We congratulate the authors for presenting this most comprehensive review of PTE from both basic science and clinical perspectives."—Journal of Neurosurgery

Product details

  • Edition: 1
  • Latest edition
  • Published: October 24, 2022
  • Language: English

About the authors

CJ

Carrie R. Jonak

Carrie R. Jonak (research associate) is a neuroscience researcher in Dr. Binder’s laboratory, in the Division of Biomedical Sciences at the University of California, Riverside.
Affiliations and expertise
Neuroscience reseracher, Division of Biomedical Sciences, University of California, Riverside, USA

AP

Allison R. Peterson

Allison Peterson is a Ph.D. candidate (graduate student in Biomedical Sciences) in Dr. Binder’s laboratory in the Division of Biomedical Scienecs at the University of California, Riverside.
Affiliations and expertise
Ph.D. candidate, Division of Biomedical Scienecs at the University of California, Riverside, USA

DB

Devin K. Binder

Originally from the Bay Area, Devin K. Binder went to Harvard University as an undergraduate, where he studied biology, anthropology, and neuroscience. He was awarded the Hoopes Prize at Harvard for his summa cum laude senior honors thesis “Serotonin and behavioral state.” Deciding to pursue both neuroscience and clinical medicine, he enrolled in the M.D./Ph.D. program at Duke University. At Duke, he graduated 1st in his medical school class, and contributed to epilepsy neuroscience with his Ph.D. dissertation “The functional role of neurotrophins in the kindling model of epilepsy.” Subsequently, Binder completed a one-year internship in general surgery at the University of California, San Francisco, and a six-year residency in neurological surgery at UCSF. At UCSF, he did a one-year fellowship in the laboratory of Dr. Alan Verkman, leader in the field of aquaporin biology. Following residency, Binder was awarded the Van Wagenen neurosurgical fellowship for one year of neuroscience and neurosurgery at the University of Bonn. There, he did another fellowship in the laboratory of Dr. Christian Steinhäuser, Director of the Institute for Cellular Neuroscience at the University of Bonn. Following a three-year stint at the University of California, Irvine, in the Departments of Neurological Surgery and Anatomy & Neurobiology, Binder joined the Division of Biomedical Sciences at the University of California, Riverside School of Medicine in January 2010. Binder runs the NIH-funded Translational Neuroscience Laboratory, and conducts research on astrocytes, epilepsy, and neurophotonics. Binder has been publishing in the epilepsy field since the 1990s, and has publications since 2004 relevant to astrocyte contribution to seizures and epilepsy. He is the previous co-author of 3 books, 2 related to epilepsy, currently holds 2 NIH grants related to epilepsy, and sits on leadership committees of the American Epilepsy Society.
Affiliations and expertise
Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA

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