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Elsevier

Principles of Clinical Pharmacology

  • 1st Edition - August 23, 2001
  • Latest edition
  • Editors: Arthur J. Atkinson Jr., Charles E. Daniels, Robert Dedrick, Charles V. Grudzinskas, Sanford P. Markey
  • Language: English

The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by… Read more

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Description

The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. Principles of Clinical Pharmacology focuses on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents.

Key features

Key Features* Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy* Unusual cohesiveness of presentation that stems from author participation in an ongoing popular NIH course* Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study* Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry

Readership

Clinical pharmacologists and clinicians, as well as the pharmaceutical industry.

Table of contents

IntroductionPART 1: PHARMACOKINETICS:Clinical pharmacokinetics.Compartmental analysis of drug distribution.Drug absorption and bioavailability.Effects of renal disease on pharmacokinetics.Kinetics of hemodialysis and hemofiltration.Effects of liver disease on pharmacokinetics.Noncompartmental vs. compartmental approaches to pharmacokinetic analysis.Distributed models of drug kinetics.Population pharmacokinetics. PART 2: DRUG METABOLISM AND TRANSPORT:Pathways of drug metabolism.Chemical assay of drugs and drug metabolites.Pharmacogenetics.Drug interactions.Biochemical mechanisms of drug toxicity.Equilibrative and concentrative transport. PART 3: ASSESSMENT OF DRUG EFFECTS:Physiological and laboratory markers of drug effect.Dose response and concentration response analysis.Kinetics of pharmacologic effect.Disease progression models.PART 4: OPTIMIZING AND EVALUATING DRUG THERAPY:Sex differences in pharmacokinetics and pharmacodynamics.Drug therapy in pregnant and nursing women.Drug therapy in neonates and pediatric patients.Drug therapy in the elderly.Clinical analysis of adverse drug reactions.Quality assessment of drug therapy.PART 5: DRUG DISCOVERY AND DEVELOPMENT:Project management.Drug discovery.Pre-clinical development.Animal scale up.Phase I studies.PK and PD considerations in the development of biotechnology products and large molecules. Design of clinical development programs.Role of the FDA in guiding drug development.Appendix I: Table of Laplace TransformsAppendix II: Answers to Study Problems

Review quotes

"...this book fulfills the long-felt need for an updated publication in Clinical Pharmacology."—INDIAN JOURNAL OF PHARMACOLOGY (2003)"...this book is for the reader who wants a detailed in- depth understanding of clinical pharmacology."—E STREAMS (2003)

Product details

  • Edition: 1
  • Latest edition
  • Published: September 21, 2001
  • Language: English

About the editors

AA

Arthur J. Atkinson Jr.

Arthur J. Atkinson, Jr., M.D., M.A.C.P., is Adjunct Professor of Pharmacology at the Feinberg Medical School of Northwestern University. He has held leadership roles in clinical pharmacology for more than 50 years, working in both academia and the pharmaceutical industry, and for NIH. He founded and for 24 years directed a Clinical Pharmacology Center at Northwestern, rising to the rank of Professor of Pharmacology and Medicine. He was subsequently Corporate Vice President for Clinical Development and Medical Affairs at the Upjohn Company. Following the Upjohn-Pharmacia merger, he was recruited to be Senior Advisor in Clinical Pharmacology at the NIH Clinical Center. There, he initiated a clinical pharmacology course and served as lead editor for the previous three editions of Principles of Clinical Pharmacology, the required text for the course. Dr. Atkinson has been elected Master of the American College of Physicians and to membership in the American Association of Physicians. He received the Harry Gold Award from ASPET, the Oscar Hunter Award from ASCPT, and the Award in Excellence from the PhRMA Foundation.
Affiliations and expertise
Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States

CD

Charles E. Daniels

Affiliations and expertise
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA

RD

Robert Dedrick

Affiliations and expertise
National Institute of Health, Bethesda, Maryland, U.S.A.

CG

Charles V. Grudzinskas

Affiliations and expertise
Center for Drug Development Science at Georgetown University, U.S.A.

SM

Sanford P. Markey

Affiliations and expertise
National Institute of Mental Health, Bethesda, Maryland, U.S.A.