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Elsevier

Principles of Clinical Pharmacology

  • 2nd Edition - September 20, 2006
  • Newer edition is available
  • Editors: Arthur J. Atkinson Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey
  • Language: English

This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals… Read more

Description

This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.

Key features

  • Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy
  • Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course
  • Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study
  • Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry
  • Expanded coverage of pharmacogenetics
  • Expanded coverage of drug transporters and their role in interactions
  • Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions
  • A new chapter on drug discovery that focuses on oncologic agents
  • Inclusion of therapeutic antibodies in chapter on biotechnology products

Readership

Clinical pharmacologists, pharmacologists, clinicians, pharmaceutical industry and government regulatory agencies

Table of contents

1. Introduction

PART 1: PHARMACOKINETICS

2. Clinical pharmacokinetics

3. Compartmental analysis of drug distribution

4. Drug absorption and bioavailability

5. Effects of renal disease on pharmacokinetics

6. Kinetics of hemodialysis and hemofiltration

7. Effects of liver disease on pharmacokinetics

8. Noncompartmental vs. compartmental approaches to pharmacokinetic analysis

9. Distributed models of drug kinetics

10. Population pharmacokinetics

PART 2: DRUG METABOLISM AND TRANSPORT

11. Pathways of drug metabolism

12. Biochemical mechanisms of drug toxicity

13. Chemical assay of drugs and drug metabolites

14. Equilibrative and concentrative transport

15. Pharmacogenetics

16. Drug interactions

PART 3: ASSESSMENT OF DRUG EFFECTS

17. Physiological and laboratory markers of drug effect

18. Dose response and concentration response analysis

19. Kinetics of pharmacologic effect

20. Disease progression models

PART 4: OPTIMIZING AND EVALUATING PATIENT THERAPY

21. Sex differences in pharmacokinetics and pharmacodynamics

22. Drug therapy in pregnant and nursing women

23. Drug therapy in neonates and pediatric patients

24. Drug therapy in the elderly

25. Clinical analysis of adverse drug reactions

26. Quality assessment of drug therapy

PART 5: DRUG DISCOVERY AND DEVELOPMENT

27. Project management

28. Drug discovery

29. Pre-clinical development

30. Animal scale up

31. Phase I studies

32. PK and PD considerations in the development of biotechnology products and large molecules

33. Design of clinical development programs

34. Good design practices for clinical trials

35. Role of the FDA in guiding drug development

Appendix
I. Table of Laplace Transforms
II. Answers to Study Problems

Review quotes

"Recent advances in pharmacogenetics, membrane transport, and biotechnology warrant a second edition of this excellent book...This will serve as an excellent text for an advanced course in principles of clinical pharmacology for graduate students, physicians, and PharmDs. Because of recent advances, the second edition is welcome."—Thomas L. Pazdernik, PhD, University of Kansas Medical Center, FOR DOODY'S (4 Stars)

Product details

About the editors

AA

Arthur J. Atkinson Jr.

Arthur J. Atkinson, Jr., M.D., M.A.C.P., is Adjunct Professor of Pharmacology at the Feinberg Medical School of Northwestern University. He has held leadership roles in clinical pharmacology for more than 50 years, working in both academia and the pharmaceutical industry, and for NIH. He founded and for 24 years directed a Clinical Pharmacology Center at Northwestern, rising to the rank of Professor of Pharmacology and Medicine. He was subsequently Corporate Vice President for Clinical Development and Medical Affairs at the Upjohn Company. Following the Upjohn-Pharmacia merger, he was recruited to be Senior Advisor in Clinical Pharmacology at the NIH Clinical Center. There, he initiated a clinical pharmacology course and served as lead editor for the previous three editions of Principles of Clinical Pharmacology, the required text for the course. Dr. Atkinson has been elected Master of the American College of Physicians and to membership in the American Association of Physicians. He received the Harry Gold Award from ASPET, the Oscar Hunter Award from ASCPT, and the Award in Excellence from the PhRMA Foundation.
Affiliations and expertise
Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States

DA

Darrell R. Abernethy

Affiliations and expertise
National Institute on Aging, Baltimore, Maryland, U.S.A.

CD

Charles E. Daniels

Affiliations and expertise
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA

RD

Robert Dedrick

Affiliations and expertise
National Institute of Health, Bethesda, Maryland, U.S.A.

SM

Sanford P. Markey

Affiliations and expertise
National Institute of Mental Health, Bethesda, Maryland, U.S.A.

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