Protein Kinase Inhibitors
The Promise of Natural Products in Cancer Therapeutics
- 1st Edition - September 1, 2026
- Latest edition
- Editors: Md. Imtaiyaz Hassan, Saba Noor
- Language: English
Protein Kinase Inhibitors: The Promise of Natural Products in Cancer Therapeutics explores a novel therapeutic avenue for cancer treatment through nutraceutical-based kinase inhibi… Read more
Description
Description
Protein Kinase Inhibitors: The Promise of Natural Products in Cancer Therapeutics explores a novel therapeutic avenue for cancer treatment through nutraceutical-based kinase inhibitors. The book covers their historical background, outlook, mechanistic pathways, and clinical aspects, highlighting their relevance in cancer therapy. It also examines the potential of polyphenolic derivatives and other natural compounds in inhibiting key kinases involved in major cancer signaling pathways, focusing on their application in clinical trials and marketed drugs. Sections explore the implications of polyphenols in cancer management, novel sources of breast cancer inhibitors, the role of natural products in lymphoma therapy, and the multitarget potential of phytochemicals.
Each chapter is designed to provide a thorough understanding of how natural products can be harnessed to develop innovative cancer therapeutics. It will serve as a valuable resource for academics, scientists, young researchers, students, and pharmacists working or interested in kinase biology and cancer therapeutics with its unique perspective on using nature's own arsenal to combat cancer.
Each chapter is designed to provide a thorough understanding of how natural products can be harnessed to develop innovative cancer therapeutics. It will serve as a valuable resource for academics, scientists, young researchers, students, and pharmacists working or interested in kinase biology and cancer therapeutics with its unique perspective on using nature's own arsenal to combat cancer.
Key features
Key features
- Explores a novel therapeutic avenue for cancer by investigating nutraceutical-based kinase inhibitors
- Provides detailed scientific explanations on how natural products influence kinase activity and cancer progression
- Highlights nutraceuticals with demonstrated potential in clinical trials or as marketed drugs, emphasizing their practical application in cancer therapy
- Explores structure-based drug design, showcasing how natural polyphenolic compounds can be used to develop new, effective cancer therapies
- Combines insights from various fields, including biochemistry, pharmacology, and oncology
Readership
Readership
Academics, scientists, young researchers, students, and pharmacists working or interested in kinase biology. The book will also provide a comprehensive overview to undergraduates and postgraduates interested in cell signaling and drug discovery
Table of contents
Table of contents
1. Nutraceuticals: From History to Modern Outlook
2. Implications of Polyphenols in Cancer Management
3. Revealing Novel Sources of Breast Cancer Inhibitors
4. A Promising Natural Product in Diffuse Large B-Cell Lymphoma Therapy
5. Inhibiting Inflammation via IL-17/NF-κB Pathway
6. Mechanistic Pathways and Clinical Aspects of Natural CDK Inhibitors on Cancer Progression
7. Natural Kinase Inhibitors in Lymphoma Therapy
8. Natural Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma
9. Identification of Marine Natural Products as STAT3 Inhibitors for Efficient Anticancer Therapy
10. Multitarget Potential of Phytochemicals
11. Naturally Occurring Compounds as Potential Inhibitors of Epidermal Growth Factor Receptors
12. Exploring Potential Phytochemicals for Hepatocellular Carcinoma
13. The Natural Product in Resistant Lung Cancer
14. Anticancer Potential of Novel Natural Product Derivatives Targeting the PI3K/AKT Signaling Pathway
15. Plant-Based mTOR Inhibitors for Cancer Therapy
16. Role of Nutraceuticals in Combating Oxidative Stress via Modulating MAPK Signalling
17. Epigenetic Effects of SCFAs: Butyrate’s Effects on Spleen Tyrosine Kinase (Syk) in Tumor Progression
18. Exploring Chemopreventive Effects of Olive Products Attenuating Cancer Signaling
19. Confronting Overexpressed Tyrosine Kinases with Curcumin: Advancing Adjuvant Cancer Therapies
20. Medicinal Benefits of Polyphenols in Cancer Prevention and Therapy through Suppression of PI3K Pathway
21. Structural Biology-Based Design of Selective Protein Kinase Inhibitors
22. Identifying Novel Cyclin-Dependent Kinase Attenuators Based on High Throughput Screening
23. Exploring the Potential of Pseudosaccharine Derivatives as Anti-Proliferative Agents and Kinase Inhibitors
24. Integrating Structure-Based Modeling and Advanced MD Simulation Strategy in Revealing the Potency of Natural Products as Dual Kinase Inhibitors
25. Discovering Novel Kinase Inhibitors: Moving from Structure to Clinical Leads
2. Implications of Polyphenols in Cancer Management
3. Revealing Novel Sources of Breast Cancer Inhibitors
4. A Promising Natural Product in Diffuse Large B-Cell Lymphoma Therapy
5. Inhibiting Inflammation via IL-17/NF-κB Pathway
6. Mechanistic Pathways and Clinical Aspects of Natural CDK Inhibitors on Cancer Progression
7. Natural Kinase Inhibitors in Lymphoma Therapy
8. Natural Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma
9. Identification of Marine Natural Products as STAT3 Inhibitors for Efficient Anticancer Therapy
10. Multitarget Potential of Phytochemicals
11. Naturally Occurring Compounds as Potential Inhibitors of Epidermal Growth Factor Receptors
12. Exploring Potential Phytochemicals for Hepatocellular Carcinoma
13. The Natural Product in Resistant Lung Cancer
14. Anticancer Potential of Novel Natural Product Derivatives Targeting the PI3K/AKT Signaling Pathway
15. Plant-Based mTOR Inhibitors for Cancer Therapy
16. Role of Nutraceuticals in Combating Oxidative Stress via Modulating MAPK Signalling
17. Epigenetic Effects of SCFAs: Butyrate’s Effects on Spleen Tyrosine Kinase (Syk) in Tumor Progression
18. Exploring Chemopreventive Effects of Olive Products Attenuating Cancer Signaling
19. Confronting Overexpressed Tyrosine Kinases with Curcumin: Advancing Adjuvant Cancer Therapies
20. Medicinal Benefits of Polyphenols in Cancer Prevention and Therapy through Suppression of PI3K Pathway
21. Structural Biology-Based Design of Selective Protein Kinase Inhibitors
22. Identifying Novel Cyclin-Dependent Kinase Attenuators Based on High Throughput Screening
23. Exploring the Potential of Pseudosaccharine Derivatives as Anti-Proliferative Agents and Kinase Inhibitors
24. Integrating Structure-Based Modeling and Advanced MD Simulation Strategy in Revealing the Potency of Natural Products as Dual Kinase Inhibitors
25. Discovering Novel Kinase Inhibitors: Moving from Structure to Clinical Leads
Product details
Product details
- Edition: 1
- Latest edition
- Published: September 1, 2026
- Language: English
About the editors
About the editors
MH
Md. Imtaiyaz Hassan
Dr. Md. Imtaiyaz Hassan, Ph.D., FRSB., FRSC., is a Professor at the Centre for Interdisciplinary Research in Basic Sciences, in Jamia Millia Islamia, New Delhi, India. His research focuses on and design and development of potent and selective kinase inhibitors, as well as understanding the mechanism of folding and dynamic behavior of potential drug targets. Dr. Hassan has published widely in such peer reviewed journals as the International Journal of Biological Macromolecules, Spectrochimica Acta, Scientific Reports, and the OMICS A Journal of Integrative Biology.
Affiliations and expertise
Professor, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, IndiaSN
Saba Noor
Dr. Saba Noor is a Research Associate at the Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India. Dr. Noor has expertise in molecular oncology, and her current research interests lie in development of kinase inhibitors for use in cancer therapeutics. She has published in such peer reviewed journals as Frontiers in Microbiology and International Journal of Biological Macromolecules, among other journals.
Affiliations and expertise
Research Associate, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India