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Elsevier

Recent Advances in Medicinal Chemistry, Volume 1

  • 1st Edition - June 2, 2015
  • Latest edition
  • Editors: Atta-ur Rahman, Muhammad Iqbal Choudhary, George Perry
  • Language: English

Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in… Read more

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Description

Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.

Key features

  • Edited and written by leading experts in medicinal chemistry research
  • Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles
  • Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health

Readership

Medicinal Chemistry and Pharma researchers

Table of contents

  • Foreword
  • Preface
  • List of Contributors
  • Chapter 1: New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs
    • Abstract
    • 1 Introduction
    • 2 Principal Functions of NSAIDs and Aureolic Acid Anticancer Antibiotics and their Mechanism of Action
    • 3 Other Functions of these Drugs and Mechanism of Actions
    • 4 Chemical Dissection of the Drugs to Understand Alternate Functions
    • 5 Conclusion
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Chapter 2: Updated Report on a Novel Mercaptopyruvate Sulfurtransferase Thioredoxin-Dependent Redox-Sensing Molecular Switch: A Mechanism for the Maintenance of Cellular Redox Equilibrium
    • Abstract
    • Introduction
    • A Redox-Sensing Molecular Switch Formed via an Intermolecular Disulfide Bond
    • Low Redox Potential Sulfenate Formation At A Catalytic Site Cysteine: Another Mechanism By Which Mst Serves As An Anti-Oxidant Protein
    • Conclusions
    • Acknowledgements
    • Conflict Of Interest
    • Disclosure
  • Chapter 3: Characterization of Inorganic Nanomaterials as Therapeutic Vehicles
    • Abstract
    • Introduction
    • Concluding Remarks
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Chapter 4: Aromatase Inhibitors: A New Reality for the Adjuvant Endocrine Treatment of Early-Stage Breast Cancer in Postmenopausal Women
    • Abstract
    • Introduction
    • Conclusions
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Chapter 5: Bacterial FabH: Towards the Discovery of New Broad-Spectrum Antibiotics
    • Abstract
    • Introduction
    • Bacterial Type II FAS the Biological Process
    • FabH as a Drug Target Differences and Advantages
    • Three Dimensional Structure of FabH
    • Substrate Binding and Specificity
    • Catalytic Mechanism and Substrate Binding
    • Molecular Modeling Studies of FabH
    • Concluding Remarks
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Chapter 6: Tannins and their Influence on Health
    • Abstract
    • 1 Introduction
    • 2 Classification of Tannins
    • 3 Absorption and Metabolism of Tannins
    • 4 Biological Activity
    • 5 Human Intervention Studies
    • 6 Adverse and Undesirable Effects
    • 7 Conclusions
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
    • Abbreviations
  • Chapter 7: Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors?
    • Abstract
    • Introduction
    • Role of RhoA in Normal and Tumor Cells
    • Statins Inhibit RhoA Activity
    • Statins and Tumor Growth/Apoptosis
    • Statins and Angiogenesis
    • Statins and Metastasis
    • Statins, Chemotherapy Efficacy and Multidrug Resistance
    • Statins and Chemoprevention of Tumors
    • Statins in Cancer Treatment
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Chapter 8: Carotenoids that are Involved in Prostate Cancer Risk
    • Abstract
    • Introduction
    • Types of Carotenoids and their Distribution in Diets
    • Conclusions
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Chapter 9: Preclinical Studies of Saponins for Tumor Therapy
    • Abstract
    • Diverse Structures and Functions of Saponins
    • Saponins as Anti-Cancer Agents
    • Dioscins
    • Saikosaponins
    • Julibrosides
    • Soy Saponins
    • Ginseng Saponins
    • Avicins
    • Knowledge, Gaps and Future
    • Combinations of Saponins and Other Anti-Cancer Agents
    • Conclusions
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
    • Abbreviations
  • Chapter 10: Pharmacological Neuroprotection for Acute Spinal Cord Injury
    • Abstract
    • 1 Introduction
    • 2 Epidemiology
    • 3 Pathophysiology
    • 4 Search Criteria
    • 5 Current Treatment of Acute Spinal Cord Injuries
    • 6 Promising Future Pharmacological Therapies
    • Conclusions
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Chapter 11: HPLC and its Essential Role in the Analysis of Tricyclic Antidepressants in Biological Samples
    • Abstract
    • 1 Introduction
    • 2 Chemistry and Activity
    • 3 Analytical Methods
    • 4 Conclusions
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
    • Abbreviations
  • Chapter 12: Gene Expression Profiles in Breast Cancer to Identify Estrogen Receptor Target Genes
    • Abstract
    • Introduction
    • Estrogen Receptors
    • Mechanisms of ER Action
    • Global Gene Expression Profiling of ER Action
    • Future Considerations
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Chapter 13: Trans-Plasma Membrane Electron Transport in Human Blood Platelets: An Update
    • Abstract
    • Plasma Membrane Redox System
    • Medicinal Effects on Platelet PMR System
    • Acknowledgements
    • Conflict of Interest
    • Abbreviations
  • Chapter 14: Role of Intermediate States in Protein Folding and Misfolding
    • Abstract
    • Introduction
    • Acknowledgements
    • Conflict of Interest
    • Disclosure
  • Index

Product details

  • Edition: 1
  • Latest edition
  • Published: June 16, 2015
  • Language: English

About the editors

AR

Atta-ur Rahman

Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan

MC

Muhammad Iqbal Choudhary

Muhammad Choudhary, PhD, is a Professor of the International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan. He is a member of the Royal Society of Chemistry, London; American Chemical Society; International Union of Pure and Applied Chemistry (IUPAC); American Society of Pharmacology; New York Academy of Sciences; Federation of Asian Chemical Societies (FACS); and he serves on the executive board of the Asian Network of Research on Anti Diabetic Plants (ANRAP). He is a recipient of the National Book Foundation's Prize for Chemistry and the Economic Cooperation Organization (ECO) Award in Education, 2006, given by the President of Azerbaijan. He has published 24 books, more than 570 papers, and 20 patents.
Affiliations and expertise
Professor, International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Karachi, Pakistan

GP

George Perry

Dr. George Perry, Ph.D. Professor of Biology and Chemistry Semmes Foundation Distinguished University Chair in Neurobiology He is a neuroscientist known for his work on neuronal oxidation of nucleic acids in Alzheimer's disease. He is distinguished as one of the top Alzheimer’s disease researchers with over 1000 publications, won numerous awards, and is one of the top 100 most-cited scientists.
Affiliations and expertise
Department of Biology, The University of Texas at San Antonio, University of Texas, San Antonio, TX, USA

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