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Reverse Aging

Current Research and Future Directions

  • 1st Edition - April 17, 2026
  • Latest edition
  • Editors: Sandeep Kumar Singh, Shailendra Kumar Mishra
  • Language: English

Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, geneti… Read more

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Description

Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.

Key features

  • Provides a multifaceted view of the latest scientific research on aging and reverse aging concepts
  • Describes cellular and molecular mechanisms associated with the aging process
  • Explores rejuvenation and aging reversal advances aimed at addressing the challenges of the aging population
  • Promotes aging knowledge to support informed healthcare decisions about health and longevity

Readership

Researchers, scientists in the field of aging and longevity seeking a comprehensive overview of the latest research on reverse aging concepts and advances

Table of contents

1 Aging: Concept, theories, principle and future prospective
Priti Gupta, T.S. Gopenath, Manuel Leri, Avinash Prakash, Vivek Jain, Umesh Kumar, Sandeep Kumar Singh

2 Overview of hallmarks of aging
Anjali Sangeeth, Manivannan Subramanian, Aditi Singh, Amit Singh

3 Reverse aging: Concept, significance, theories and future prospective
Anita Yadav, Anusha Kamath

4 Reprogramming a cell’s epigenetic status for reverse aging
Pradeep Kumar Mishra, Krishna Kumar Singh, Shampa Ghosh, Jitendra Kumar Sinha

5 Cellular reprogramming for reverse aging
Pradeep Kumar Mishra, Shampa Ghosh, Krishna Kumar Singh, Jitendra Kumar Sinha

6 NANOG: A key element for reverse aging
Vishakha Rathi, Umesh Kumar, Lakshita Tyagi, Garima Rathi, Neelam Thakur, Sandeep Kumar Singh, Jagdip Singh Sohal, Kaushik Das

7 Reduction of IGF‑1/PKA to promote hematopoietic‑stem cell‑based reverse aging
Devesh Kumar Mishra, Shailendra Kumar Mishra, Kratika Tiwari, Rounak Dubey, T.S. Gopenath, Manuela Leri, Soraya L. Valles, Adrian Jorda, Koyel Kar, Burkhard Poeggeler, Hung‑Ming Chang, Mahendra Pratap Singh, Sandeep Kumar Singh

8 Rejuvenating stem cells to reverse aging
Sonam Ranwa, Sakshi Yadav, Stanzin Nurboo, Aamir Nazir

9 Histone modification (H3K27) to reverse aging
Soumyaparna Das, Vibha Dwivedi, Anand Kumar Singh

10 Autophagy as a therapeutic target to enhance reverse aging
Oleh Akimov, Vitalii Kostenko, Heorhii Kostenko, Viktoriia Kostenko

11 mRNA enhanced cell therapy and reverse aging
Vibha Dwivedi, Mukulika Ray, Anand Kumar Singh

12 Reverse aging through immune driven signaling
Umesh Kumar, Simran, Lakshita Tyagi, Shreeja Mishra, Manisha Gupta, Jagdip Singh Sohal

13 Mitochondrial modulations for reverse aging
Dickson Achimugu Musa, Mohammed Olumide Raji

14 Reverse aging through cell cycle regulation
Poonam Sheoran, Rahul Dev Tripathi, Shailendra Kumar Mishra, Nitin Kumar Marathe, Anita Yadav, Anuradha Bhardwaj, Pallavi Singh, Kamal Singh, Maria A. Tikhonova, T.S. Gopenath, Soraya L. Valles, Adrian Jorda, Mahendra Pratap singh, Sandeep Kumar Singh

15 Metabolic reprogramming for reverse aging
Dickson Achimugu Musa, Kolawole Harun Aremu

16 Diets, phytochemicals, drugs, and nutraceuticals for reverse aging
Pritam Kamila, Ria Dutta, Monishankar Kuilya, Sougata Neogi, Koyel Kar, Priyanka Chakraborty, Sailee Chowdhury, C. Kirubhanand, Sandeep Kumar Singh

17 Artificial intelligence and antiaging research
Saranya Arumugam, R. Muthuvel, Bibin Savio, C. Kirubhanand, Gowtham Kumar Subbaraj

18 Reverse aging through redox‑sensitive transcription factors modulation
Vitalii Kostenko, Oleh Akimov, Heorhii Kostenko, Roman Ryabushko, Viktoriia Kostenko

Product details

  • Edition: 1
  • Latest edition
  • Published: April 17, 2026
  • Language: English

About the editors

SS

Sandeep Kumar Singh

Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer’s and related Disorders Society of India. Dr. Singh has published five books, including Elsevier’s A New Era in Alzheimer’s Research and Genome Editing for Neurodegenerative Diseases.

Affiliations and expertise
Department of Medical Biotechnology, All India Institute of Medical Sciences, Nagpur, MH, India

SM

Shailendra Kumar Mishra

Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer’s Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.
Affiliations and expertise
Indian Scientific Education and Technology Foundation, Lucknow, Uttar Pradesh, India