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Elsevier

Roles of the Cerebellum in Motor Control

Foundations, Experimental Approaches and Clinical Applications

  • 1st Edition - December 1, 2026
  • Latest edition
  • Editors: Mario Manto, Dagmar Timmann, Lena Clement
  • Language: English

Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking, comprehensive reference on the intricate relati… Read more

Description

Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking, comprehensive reference on the intricate relationship between the cerebellum and motor function. Spanning five thorough sections, this book examines experimental approaches, from single neurons to networks, unraveling the mysteries of olivocerebellar somatotopy, motor prediction, and the cellular basis of motor learning. With chapters dedicated to neuroimaging, physiology, and pathophysiology, users will gain insight into the cerebellum's role in conditions such as tremor, dystonia, and Parkinson’s disease.

From wearable sensors to digital gait biomarkers, various chapters offer a cutting-edge look at sensor technology and its application in assessing cerebellar function and rehabilitation. The book concludes with a discussion on research and clinical implications, providing a roadmap for translating laboratory findings into effective therapeutic strategies, making it an indispensable resource for researchers, clinicians, and students alike.

Key features

  • Offers a diverse perspective on cerebellar motor control and its implications across disciplines
  • Explores real-world case studies and clinical vignettes to illustrate the practical application of cerebellar research in diagnosing, treating, and managing motor disorders
  • Provides valuable insights into emerging areas of research and potential future developments in cerebellar neuroscience and rehabilitation
  • Caters to a wide audience, including students, researchers, clinicians, and educators to help facilitate learning and understanding across various levels of expertise

Readership

Neuroscientists, students in medicine and psychology, biologists, trainees, rehab specialists, neuroradiologists, neuropsychologists, industry of rehab

Table of contents

SECTION 1. Experimental approaches: from single neurons to networks

1. The olivocerebellar somatotopy

2. Cerebellum-brainstem loops

3. Fastigial nuclei: inputs/outputs

4. Complex spikes

5. Memory of motor learning

6. Motor prediction and feedback in Purkinje cell activity.

7. synchrony in cerebellar cortico-nuclear interactions

8. LTD

9. Predictive computations

10. Cellular imaging of cerebello-cerebral interactions

11. Intermodular integration in the cerebellar cortex for motor control

12. Cerebellar contribution to the development of sensorimotor circuits

13. Error processing in the cerebellar cortex

14. Mechanistic and Functional Diversity in Cerebello - Cerebral Coupling

15. Cerebellum-basal ganglia interactions

SECTION 2. From sensors to digital assessment of motion

16. digital gait biomarkers / wearables / cerebellar gait / rehab

17. Wearable sensors for upper limbs

18. Camera-based analysis

19. Gait

20. Machine learning

SECTION 3. Neuroimaging

21. Imaging of the motor cerebellum / circuits

22. Cerebellum and tremor: neuroimaging aspects

23. Functional connectivity

24. The cerebellar connectome

25. Structure-function relations in dystonia

26. Functional organization and perturbation of the cerebellum

SECTION 4. Physiology and pathophysiology of motion

27. Cerebellar control of timing and eye saccade

28. Cerebello-cerebral circuit in motor control and preparation

29. Sensorimotor integration of proprioception

30. Cerebellum in reaching movement

31. Cortico-cerebellar loops in reaching movement

32. timing behind motor control

33. Neurophysiology of cerebellar motor control in NHP

34. cerebellar control of locomotion

35. Occulomotor reflexes

36. Cerebellar cortico-nuclear interactions in eyeblink conditioning

37. Neurophysiology of cerebellum in tremor

38. Cerebellum and Parkinson’s disease

SECTION 5. Research and clinical implications: from the lab to the rehabilitation

39. Cerebellar dysfunction and rehabilitation

40. Cerebellar-based therapies of motor dysfunction

41. cerebellum and fatigue

42. non-invasive cerebellar stimulation / rehab

43. Cerebellar reserve

Product details

  • Edition: 1
  • Latest edition
  • Published: December 1, 2026
  • Language: English

About the editors

MM

Mario Manto

Dr. Mario Manto is a Neurologist at the Université Libre de Bruxelles (Belgium) with more than 20 years of experience in clinical neurology, particularly cerebellar ataxia. He is a Professor of Neuroanatomy at the University of Mons (Belgium) and Researcher at the FNRS (Belgium). He has been appointed Head of the Department of Neurology of the Centre Hospitalier Universitaire (CHU) de Charleroi (Belgium). The focus of his career for more than 20 years has been the study of cerebellar disorders, from a clinical and basic science point of view. He published more than 160 peer reviewed scientific articles and 15 book chapters on cerebellar topics and he is the editor of 6 books on cerebellar disorders. He is the Founding Editor and Editor in chief of two scientific journals: The Cerebellum and Cerebellum & Ataxias. He is Deputy Editor of the Journal of Neuroengineering and Rehabilitation and a Member of Faculty 1000. He has received many grants from several foundations including the NIH, European Commission, and the Fonds National de la Recherche Scientifique of Belgium.
Affiliations and expertise
Professor of Neurology, Free University of Brussels; Professor of Neuroanatomy, University of Mons, Mons, Belgium

DT

Dagmar Timmann

Dr. Timmann received her medical degree from the University of Tübingen, Germany. She is a board-certified neurologist. She was a postdoctoral researcher at the R.S. Dow Neurological Sciences Institute (Dr. F.B. Horak), Portland, USA, at the Arizona State University, Tempe and Barrow Neurological Institute (Dr. J. Bloedel), Phoenix, USA, and at the Dept. of Physiology (Dr. J. Hore), University of Western Ontario, London, Canada. She was a visiting scholar at the Human Sensorimotor Control Laboratory (Dr. J. Konczak), University of Minnesota, Minneapolis, MN, USA.

Dr. Timmann’s research areas are the physiology and pathophysiology of the human cerebellum with a focus on human cerebellar lesion studies, lesion-behavior (“symptom”)-mapping, ataxias, structural and functional MRI of the cerebellum and cerebellar nuclei.

She is an Associate Professor of Experimental Neurology at the Department of Neurology, University Hospital Essen, University of Duisburg-Essen. Dr. Timmann is head of the Ataxia Clinic, Department of Neurology, University Hospital Essen. She is currently vice speaker of the Collaborative Research Center SFB 1280 “Extinction learning”.

Affiliations and expertise
University Hospital Essen, University of Duisburg-Essen, Germany

LC

Lena Clement

Research Director INSERM, MSc quantum physics MSc molecular pharmacology, PhD Pasteur Institute,

postdoc MIT
Affiliations and expertise
Research Director INSERM, France