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Elsevier

Signaling Pathways in Breast Cancer

Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance

  • 1st Edition - October 1, 2026
  • Latest edition
  • Editors: Sumel Ashique, Neeraj Mishra, Farzad Taghizadeh-Hesary, Maria Vliora
  • Language: English

Signaling Pathways in Breast Cancer: Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance provides an in-depth exploration of the complex molecular mechan… Read more

Description

Signaling Pathways in Breast Cancer: Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance provides an in-depth exploration of the complex molecular mechanisms that drive breast cancer progression. The book focuses on critical signaling pathways, including PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, Wnt/β-catenin, and Notch, elucidating their roles in tumor development, survival, and therapeutic resistance. The content offers a comprehensive overview of these pathways, detailing their dysregulation in breast cancer and implications for targeted therapeutic strategies. It discusses FDA-approved treatments, emerging therapies, and the mechanisms behind drug resistance, integrating recent research findings to highlight novel molecular targets and biomarker discovery. This book serves as a valuable resource for researchers, clinicians, and students, bridging the gap between basic molecular biology and clinical applications. By providing structured insights into complex signaling networks and therapeutic interventions, it equips readers with essential knowledge for developing innovative approaches to breast cancer management and improving patient outcomes.

Key features

  • Provides a detailed exploration of critical signaling pathways such as PI3K/Akt, MAPK, JAK/STAT, and Notch, elucidating their roles in tumor initiation, progression, and resistance to therapy
  • Discusses FDA-approved targeted therapies and emerging treatment strategies, including immunotherapy and personalized medicine
  • Addresses mechanisms of drug resistance and potential strategies for overcoming resistance
  • Includes case studies and biomarker-based approaches that link molecular mechanisms to clinical outcomes
  • Offers insights into ongoing clinical trials and future directions in breast cancer therapy

Readership

scientists and academics in cancer research, pharmacology and biotechnology

Table of contents

1. Introduction to Breast Cancer and Signaling Pathways

2. Emerging Molecular Targets in Breast Cancer Therapy

3. Role of Tumor Microenvironment in Breast Cancer Development

4. Molecular Subtypes of Breast Cancer and Their Clinical Significance

5. Key Signaling Pathways in Breast Cancer Progression

6. RNA-Based Therapies: miRNA and siRNA in Breast Cancer Treatment

7. Targeting Angiogenesis: VEGF and Its Inhibitors

8. Antibody-Drug Conjugates (ADCs) in Breast Cancer Treatment

9. Small Molecule Kinase Inhibitors: Current Status and Future Directions

10. Nanotechnology and Precision Drug Delivery for Breast Cancer

11. MDR and Strategies to Overcome Therapy Failure

12. Combination Therapies for Overcoming Resistance in Breast Cancer

13. Targeting Autophagy in Overcoming Multidrug Resistance

14. Role of Biomarker-Based Therapeutic Approaches

15. Role of CRISPR in Triple Negative Breast Cancer

16. ERK Signaling and Breast Cancer

17. Artificial Intelligence in Breast Cancer Therapy

18. Role of Microbiota in Breast Cancer Progression and Therapy

19. Heterogeneity and Drug Resistance in Breast Cancer

20. Advancement Therapeutic Approaches in Drug Resistance Breast Cancer Management

21. Bridging Theory and Practice in Breast Cancer: Case Studies and Clinical Insights

22. Challenges and Innovations in Therapeutic Strategies in Treatment of Breast Cancer

Product details

  • Edition: 1
  • Latest edition
  • Published: October 1, 2026
  • Language: English

About the editors

SA

Sumel Ashique

Sumel Ashique has been working as an assistant professor at Bengal College of Pharmaceutical Sciences & Research, Durgapur West Bengal, India, West Bengal, India. He has several years of teaching experience. He has achieved 70+ publications of International and national accredited reputed journals . He has knowledge in drug delivery, nanotechnology and targeted treatment strategy. He has also 6 granted patents from IP and Australia & dozens of book chapters have been submitted to well-known publishers.

Affiliations and expertise
Bengal College of Pharmaceutical Sciences & Research,

NM

Neeraj Mishra

Dr. Neeraj Mishra is Professor and Head of the Department of Pharmaceutics at the Amity Institute of Pharmacy, Gwalior. He has extensive teaching and research experience in pharmaceutics, with particular expertise in novel drug delivery systems, localized and targeted drug delivery, and nanocarrier-based therapeutics for cancer and neurodegenerative disorders. His research interests focus on advanced pharmaceutical formulations and controlled delivery approaches aimed at improving therapeutic outcomes.

Dr. Mishra has supervised postgraduate and doctoral research scholars and has contributed widely to academic literature through research publications, books, and book chapters with leading international publishers. He is also associated with innovation in pharmaceutical sciences through patented research contributions. Over the course of his career, he has received several academic and scientific recognitions for his contributions to teaching, research, and pharmaceutical education. He has additionally been recognized internationally for his research impact and scholarly contributions in the field of pharmaceutical sciences.

Affiliations and expertise
Professor and Head of Department, Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Gwalior, Madhya Pradesh, India

FT

Farzad Taghizadeh-Hesary

Dr. Farzad Taghizadeh-Hesary is an Assistant Professor of Radiation Oncology at Iran University of Medical Sciences, specializing in oncology, radiobiology, and cancer metabolism. He earned his M.D. in 2015 from IUMS and completed a Radiation Oncology residency at Shahid Beheshti University of Medical Sciences, ranking among the top graduates nationally. His thesis examined late toxicities after IMRT for nasopharyngeal carcinoma, reflecting a commitment to precision radiotherapy.

His expertise spans clinical and academic oncology, with a focus on tumor microenvironment and mitochondrial metabolism in cancer. He has published more than 80 peer-reviewed articles and serves on editorial boards including BMC Cancer and PLoS ONE. Awards include the Razi Medical Science Research Prize and the Outstanding Reviewer Award from JCO Clinical Cancer Informatics; Publons Academy ranked him the top global Radiation Oncology reviewer in 2021.

His research centers on personalized radiotherapy, cancer immunotherapy, and metabolic interventions targeting mitochondrial dysfunction, advancing translational oncology

Affiliations and expertise
Iran University of Medical Sciences, Tehran, Iran

MV

Maria Vliora

Dr. Vliora Maria is a Molecular Biologist with extensive background in molecular biology and integrative physiology. She has previously studied mutations of immunoglobulins in Chronic Lymphocytic Leukemia patients, and ALK mutations and downstream signaling in Neuroblastoma. Dr. Vliora has a PhD in Biomedical Research from University of Thessaly, Greece and University of Brescia, Italy. She has worked on the development of biocompatible/biodegradable bioscaffolds for targeting adipose tissue as well as on potential nanomedical treatments for brain tumors as well as blood malignancies. Her research work is now focusing on environmental influences that can affect human health and on the use of novel biodegradable bio-scaffolds for allografting adipose stem cells in humans. She collaborated with reputable organizations (WHO, ILO) on projects aiming to enhance human health and wellbeing. She now works as a Project Manager on EU funded projects.
Affiliations and expertise
FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece