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Elsevier

Books in Life sciences

  • Sinusoidal Cells in Liver Diseases

    Role in their Pathophysiology, Diagnosis, and Treatment
    • 1st Edition
    • Jordi Gracia-Sancho
    • English
    Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers, and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics.Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure.

  • Cranial Surgery - Part 1

    • 1st Edition
    • Volume 284
    • Jeremy Christopher Ganz
    • English
    This is a study of the evolution of the principles and techniques of cranial surgery from Hippocrates to the nineteenth century. The methods of conveying information by text and image are considered.

  • Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics

    • 1st Edition
    • Ting-Chao Chou
    • English
    “Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics” provides a comprehensive overview and update of the mass-action law-based unified dose-effect biodynamics, pharmacodynamics, bioinformatics, and the combination index theorem for synergy definition (MAL-BD/PD/BI/CI). Contents advocate the fundamental MAL-PD/BI/CI/BI principle for biomedical R&D, clinical trials protocol design computerized data analysis, illustrates the MAL-dynamics theory with sample analysis, and includes data entry and automated computer report print-outs. In 11 sections “Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics” leads the reader from an introduction and overview, to trial protocols and MAL-PD/CI approach for biomedical R&D in vitro and in animals. It describes the current Landscape of International FDA Drug Evaluation, Clinical Pharmacology, and Clinical Trials Guidance. This is a valuable resource for biomedical researchers, healthcare professionals, and students seeking to harness the power of data informatics in precision medicine.

  • Secondary Headaches, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 42-2
    • Randolph W. Evans
    • English
    In this issue of Neurologic Clinics, guest editor Randolph W. Evans brings his considerable expertise to the topic of Secondary Headaches.

  • COVID-19’s Consequences on the Cardiovascular System

    Immediate, Intermediate, and Long-Term Complications
    • 1st Edition
    • Fabian Sanchis-Gomar + 1 more
    • English
    Scientific evidence demonstrates that while COVID-19 primarily affects the lungs, it also affects multiple organs, particularly the cardiovascular system; its most common complications are arrhythmia, cardiac injury, fulminant myocarditis, heart failure, and pulmonary embolism. COVID-19’s Consequences on the Cardiovascular System: Immediate, Intermediate, and Long-Term Complications covers all aspects related to the interplay between SARS-COV-2 infection and the cardiovascular system, from bench to bedside and from acute infection to long-term complications.Writte... by a team of experts, this book is a one-stop-shop reference for healthcare professionals and researchers who require a comprehensive view of the deleterious effects of COVID-19 on the cardiovascular system. It discusses the relationship of cardiovascular risk factors with COVID-19 prognosis. It offers further insights into the biomarkers that currently make it possible to predict and monitor the evolution of the disease at the cardiovascular level.

  • Techniques for Biochemical Analysis

    • 1st Edition
    • Khursheed Hussain + 3 more
    • English
    Techniques for Biochemical Analysis provides researchers with a practical guide for investigating a variety of different biomolecules. It includes a range of tried and tested protocols, outlining the principles upon which each technique is founded, as well as providing instructions on equipment setup and use, buffer preparation, reagents required, safety considerations and analysis of findings. Beginning with an introduction to biochemistry and laboratory procedures, the book moves on to specific methods focused on investigation of carbohydrates, proteins, enzymes, plant hormones, minerals, amino acids, and more.The large range of protocols covered in this foundational, how-to reference are interdisciplinary and adaptable to a variety of areas, making this an ideal resource for researchers across various fields, including biochemistry, molecular biology, medical sciences, plant physiology, agriculture, and related subjects.

  • Microbiome-Based Decontamination of Environmental Pollutants

    • 1st Edition
    • Ajay Kumar + 2 more
    • English
    Microbiome-Based Decontamination of Environmental Pollutants explores the complex interactions of plant-associated microbiomes, providing insights into the pressing challenges of managing environmental resources such as soil, water, and waste. Analysis has shown a formidable potential based in the network interactions between plant microbiota and environmental contaminants. This book presents insights into the potential exploitation of these plant-associated microbial functions. This volume in the Plant and Soil Microbiome series summarizes microbiological aspects of environmental management from the basics to advanced theoretical as well as practical aspects of microbial-based approaches.The physical and chemical changes caused by pollution of an ecosystem can occur rapidly, significantly impacting the functionality of ecosystem services in that environment. Environmental contamination poses and increasingly global challenge through direct and indirect adverse impacts on the climate, soil productivity and the health concerns of human beings. Traditional remediation techniques are not consistently feasible in mitigating environmental contaminants challenges in terms of cost-effectiveness, limited land resources and toxic residual products. The use of plant-associated microbes as part of a network of tools opens a new door to explore an alternative, eco-friendly and economical technology to mitigate the challenges of environmental contamination.

  • Pathophysiology, Risk Factors, and Management of Chronic Heart Failure

    • 1st Edition
    • Ram B. Singh + 3 more
    • English
    Chronic Heart Failure: Pathophysiology, Risk Factors, and Mechanisms aims to provide an inclusive overview on Chronic Heart Failure (CHF).This book is focused on the epidemiology, classification, molecular mechanisms, pathophysiology, causes, identification and interactions of heart failure. It will explain the uncertainties and issues in Heart Failure by helping readers understand the physiopathology of CHF in the light of behavioural risk factors. 2D and 3D speckle tracking echocardiography have been used to quantify regional alterations of longitudinal strain and area strain, through their polar projection, which allows a further evaluation of both the site and extent of myocardial damage. The analysis of strain can identify subclinical cardiac failure (myocyte remodelling) which is a major issue in CHF. Myocardial Strain, measure by speckle tracking echocardiography, is frequently attenuated in these conditions and can be utilized for the evaluation of disease progression and the effect of therapeutic interventions as well as prevention because it could be a manifestation of behavioural risk factors.This title will function as an essential reference to both researchers and practicing clinicians, proposing novel methods of research by using behavioural and environmental risk factors as intervention agents, as well as discussing deficiency in the present approaches in management of HF and proposing new methods of early diagnosis and therapies for the clinical management of CHF.

  • Organizers in Development

    • 1st Edition
    • Volume 157
    • English
    Organizers in Development, Volume 157 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The organizer: what it meant, and means, to developmental biology, Organizers/signaling regions that pattern the limb, Organizers/signaling regions in the branchial arches, The notochord/floor plate as a possible organizer, Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula, and more.

  • Health and Environmental Effects of Ambient Air Pollution

    Volume 1: Air Pollution, Human Health, and the Environment
    • 1st Edition
    • Mohammad Hadi Dehghani + 3 more
    • English
    Health and Environmental Effects of Ambient Air Pollution is part of a series of three volumes for Air Pollution, Human Health, and the Environment. Volume 1 discusses the adverse consequences of ambient air pollutants on human health, animals, plants, and structures.This book examines the production of ambient air pollutants in the environment. It begins with an overview of the classifications, sources, and occurrences of outdoor air pollutants. This book covers meteorological, climate, and topographical factors affecting air pollution, discusses how urbanization and industrialization affect air quality, and explores how climate conditions like global warming, acid rain, and airborne particulate matter impact human health. It also looks at epidemiology studies and socioeconomic aspects of outdoor air pollution, estimating health and cost effects, air quality indices, guidelines, standards, and information networks of ambient air pollutants. With contributors from experts in the field, this book is a valuable reference for academicians, researchers, and students in environmental health, public health, and occupational health, as well as environmental engineers, meteorologists, epidemiologists, medical researchers, and environmental toxicologists.

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