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Elsevier

Books in Life sciences

  • Flavonoids Against Cancer Hallmarks

    • 1st Edition
    • Dharambir Kashyap + 1 more
    • English
    Flavonoids Against Cancer Hallmarks provides an in-depth exploration of the anti-cancer potential of flavonoids and their ability to target key cancer hallmarks. The book encompasses a thorough analysis of flavonoids' sources, bioavailability, metabolic disposition, long-term safety, and adverse effects. It highlights the mechanisms through which flavonoids inhibit cancer growth and proliferation, focusing on their immunomodulatory, anti-angiogenic, anti-metastatic, and cell cycle inhibitory effects. Designed for oncology specialists, pharmacology and pharmacy students, cancer research scholars, and pharmaceutical industry researchers, this comprehensive guide also reviews recent cancer epidemiology and updates on existing therapeutic strategies.By detailing how flavonoids counteract cancer stemness and influence immune responses, this book offers innovative insights into utilizing plant-derived compounds for cancer treatment. It stands out by providing a detailed overview of flavonoids' cellular and molecular mechanisms while also evaluating the pros and cons of current therapeutic options, making it essential reading for a global audience.

  • Antimicrobial Resistance and its Consequences on the Global Economy

    Progress towards Attaining the Sustainable Development Goals
    • 1st Edition
    • Debajyoti Bose + 3 more
    • English
    Antimicrobial Resistance and Its Consequences on the Global Economy: Progress towards Attaining the Sustainable Development Goals examines the threat that antimicrobial resistance (AMR) poses to public health, considering its impact upon prolonged illnesses, increased healthcare costs, and higher mortality rates.The book begins with an introduction to the global challenges of AMR before exploring the profound economic repercussions and the role of various sectors, including the pharmaceutical industry, agricultural practices, and food production. It also discusses ethical considerations in tackling AMR, as well as biotechnological and integrative approaches to AMR management. International responses and experiences in low- and middle-income countries are covered, in addition to the Sustainable Development Goals and future directions and recommendations. By promoting responsible antibiotic use, enhancing surveillance systems, and investing in the research and development of new antimicrobial agents, this book aims to preserve the effectiveness of existing treatments and safeguard public health for future generations.Through detailed case studies, policy recommendations, and innovative solutions, Antimicrobial Resistance and Its Consequences on the Global Economy serves as an essential resource for professionals working across microbiology, healthcare, agriculture, and related fields, equipping them with the knowledge and tools needed to implement effective AMR management practices. It also serves as a valuable resource for students across these areas, fostering a new generation of experts dedicated to preserving the efficacy of antimicrobial treatments and combating AMR effectively.

  • Pharmacology of T-Cell Therapies

    • 1st Edition
    • Volume 106
    • English
    Pharmacology of T-Cell Therapies, Volume 106 in the Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics in this new release include Enhancing persistence of therapeutic T cells, T cell manufacturing impacts on in vivo function, Transient T cell therapies, In vivo T cell therapies, T cell subsets for therapy, Engineering T cell metabolism to enhance therapeutic efficacy, and Tracking Therapeutic T cells In Vivo contacts.

  • Computational Approaches to Natural Products Discovery

    • 1st Edition
    • Volume 730
    • English
    Computational Approaches to Natural Products Discovery, Volume 720 provides descriptions of the latest techniques in computational methods for the study of natural products. Techniques covered are related to genome mining, natural product biosynthesis, natural product evolution, and natural product structure. Chapters in this new release cover Prediction of natural product bioactivity from BGC sequence to guide genome mining efforts, Genome mining for resistance genes to identify bioactive natural products with ARTS, Predicting lasso peptide structure with LassoPred, Predicting lanthipeptide structure with Rosetta, Using lsaBGC to investigate BGC Evolution, and an Analysis of BGC evolution with CORASON.

  • Cellular Communication in Development

    • 1st Edition
    • Volume 169
    • English
    Cellular Communication in Development, Volume 169 provides a comprehensive overview of the intricate signaling pathways and molecular mechanisms that govern how cells communicate during the development of multicellular organisms. This volume explores the essential roles of cell-to-cell communication in processes such as embryogenesis, tissue patterning, organ formation, and differentiation. Specific chapters include Specification of pgcs, Establishing and maintaining gonadal cell fate, Role of retinoic acid in meiosis, Assembly of primordial follicles, Activation of primordial follicles, Mechanisms of germ-soma communication during follicular growth, Somatic regulation of oocyte meiotic arrest and resumption, Ovarian stroma/function/role in aging, and much more.Additional sections explore New approaches to supporting follicle growth/ovarian function in vitro, Cancer therapy - effects on survival/development of oocyte/follicle, Female germ cells from somatic cells, Spermatogenic stem cell niche, Role of macrophages in testis function, Male germ cells from somatic cells, and more.

  • ​​Cannabinoids for Chronic Pain

    From Research to Clinical Applications​
    • 1st Edition
    • Alaa Abd-Elsayed
    • English
    Cannabinoids for Chronic Pain: From Research to Clinical Applications provides an in-depth exploration of cannabinoids and their applications in modern medicine. The book begins with an historical overview, followed by a detailed examination of the endocannabinoid system and cannabinoid receptors. Next, sections cover various phytocannabinoids, including CBD and THC, as well as synthetic cannabinoids like dronabinol and nabilone. Each chapter delves into the pharmacokinetics, pharmacodynamics, actions, and side effects. The content is meticulously organized to address the medical uses of cannabinoids, including in pain management, perioperative care, and their applications in specific populations such as children, pregnant women, and the elderly.Sections also discuss the medicolegal considerations surrounding cannabinoid use. Contributions from leading experts provide evidence-based recommendations and practical guidelines for clinical practice, ensuring a comprehensive understanding of the subject. This book is an invaluable resource for healthcare professionals, researchers, and students. It bridges the gap between research and clinical practice, offering practical insights and up-to-date information. Readers will benefit from its thorough coverage, multidisciplinary perspectives, and detailed discussions, making it an essential guide for anyone involved in the medical use of cannabinoids.

  • Systemic Lupus Erythematosus

    Basic, Applied and Clinical Aspects
    • 3rd Edition
    • George C. Tsokos
    • English
    Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects has been an essential resource for scientists and clinicians in this field since its original publication in 2015. The third edition of this work has been completely updated and expanded with the latest scientific and clinical developments in Systemic Lupus Erythematosus (SLE) to date. Contributors at the forefront of each topic come together to enhance content on epidemiology and diagnosis, pathogenesis, mechanisms of tissue damage, clinical aspects of the disease, antiphospholipid syndrome, and treatments. Also added is the latest information on new treatments, criteria, monogenic forms of lupus, insights on the role of microbiome, and advances in understanding disease pathogenesis. This must-have reference is an indispensable resource for specialists in the diagnosis and management of patients with SLE as well as early career or experienced investigators studying basic aspects of the disease. It is a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a key reference work for hospital libraries.

  • Innovative Nanocarriers for Stimulated Drug Delivery

    A Comprehensive Guide to Stimuli-responsive Nanoparticles
    • 1st Edition
    • Prashant Kesharwani
    • English
    Innovative Nanocarriers for Stimulated Drug Delivery: A Comprehensive Guide to Stimuli-responsive Nanoparticles summarizes recent advances and achievements in nanocarriers responsive to external or internal stimuli. The book presents different stimuli-sensitive strategies and their applications in drug delivery, therapy, and theranostics. Sections provide fundamental knowledge on the experiential and experimental aspects of stimuli-responsive nanocarriers, discuss external-responsive nanocarriers for biomedical applications, such as ultrasound, thermal, magnetic, light, and electric field-response systems, and describe internal stimuli-responsive nanocarriers for biomedical applications, including pH, hypoxia, redox potential, enzyme, glucose, and microRNA-responsive nanocarriers. Additionally, the book covers dual and multimodal-responsiv... nanocarriers and the therapeutic aspects of stimuli-responsive nanocarriers, such as metallic and non-metallic stimuli-responsive nanocarriers in the treatment of various cancer and noncancerous diseases. Finally, recent advances and regulatory aspects of stimuli-responsive nanocarriers, including clinical translation, challenges, biological toxicity, safety issues, clinical trials, and future perspectives are covered.

  • The Rat Nervous System

    • 5th Edition
    • George Paxinos + 1 more
    • English
    The Rat Nervous System, Fifth Edition is an indispensable guide for researchers and students in neuroscience who are working on the rat and mouse as experimental models. The new edition provides thorough updates throughout, including the latest information in an active field of research on the brain, spinal cord, and peripheral nervous system and their unique functions. Readers will learn how to formulate sound hypotheses as well as carry out accurate research models.

  • Essentials of Stem Cell Biology

    • 4th Edition
    • Robert Lanza + 1 more
    • English
    Essentials of Stem Cell Biology, Fourth Edition is designed for the growing community of scientists, researchers, practitioners, and students embracing the latest advancements in stem cells. This comprehensive book, a collaboration of 7 editors and over 200 pioneering scholars and scientists, provides a thorough understanding of adult and embryonic stem cells. It combines fundamental concepts with cutting-edge research in specific organ systems, ensuring a robust foundation for anyone entering the field. Beyond the basics, the book delves into early development and the differentiation of ectoderm, mesoderm, and endoderm.It covers methods, applications to human diseases, regulation, ethics, and patient perspectives, leaving no stone unturned in the stem cell domain.

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