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Elsevier

Books in Chemistry

Chemistry topic areas include: physical and theoretical, computational, organic, organometallic and inorganic, pharmaceutical and medicinal, analytical and bioanalytical, nuclear, general, nanochemistry, geochemistry, materials and polymer, as well as environmental, green and sustainable chemistry.

  • NMR Spectroscopy in Pharmaceutical Analysis

    • 1st Edition
    • Ulrike Holzgrabe + 2 more
    • English
    For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples.

  • Collisional Effects on Molecular Spectra

    Laboratory Experiments and Models, Consequences for Applications
    • 1st Edition
    • Jean-Michel Hartmann + 2 more
    • English
    Gas phase molecular spectroscopy is a powerful tool for obtaining information on the geometry and internal structure of isolated molecules as well as on the interactions that they undergo. It enables the study of fundamental parameters and processes and is also used for the sounding of gas media through optical techniques. It has been facing always renewed challenges, due to the considerable improvement of experimental techniques and the increasing demand for accuracy and scope of remote sensing applications. In practice, the radiating molecule is usually not isolated but diluted in a mixture at significant total pressure. The collisions among the molecules composing the gas can have a large influence on the spectral shape, affecting all wavelength regions through various mechanisms. These must be taken into account for the correct analysis and prediction of the resulting spectra. This book reviews our current experimental and theoretical knowledge and the practical consequences of collisional effects on molecular spectral shapes in neutral gases. General expressions are first given. They are formal of difficult use for practical calculations often but enable discussion of the approximations leading to simplified situations. The first case examined is that of isolated transitions, with the usual pressure broadening and shifting but also refined effects due to speed dependence and collision-induced velocity changes. Collisional line-mixing, which invalidates the notion of isolated transitions and has spectral consequences when lines are closely spaced, is then discussed within the impact approximation. Regions where the contributions of many distant lines overlap, such as troughs between transitions and band wings, are considered next. For a description of these far wings the finite duration of collisions and concomitant breakdown of the impact approximation must be taken into account. Finally, for long paths or elevated pressures, the dipole or polarizability induced by intermolecular interactions can make significant contributions. Specific models for the description of these collision induced absorption and light scattering processes are presented. The above mentioned topics are reviewed and discussed from a threefold point of view: the various models, the available data, and the consequences for applications including heat transfer, remote sensing and optical sounding. The extensive bibliography and discussion of some remaining problems complete the text.

  • Capillary Electrophoresis Methods for Pharmaceutical Analysis

    • 1st Edition
    • Volume 9
    • Satinder Ahuja + 1 more
    • English
    Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.

  • Inorganic Chemistry

    • 1st Edition
    • James E. House
    • English
    Inorganic Chemistry provides essential information in the major areas of inorganic chemistry. The author emphasizes fundamental principles—including molecular structure, acid-base chemistry, coordination chemistry, ligand field theory, and solid state chemistry — and presents topics in a clear, concise manner. Concise coverage maximizes student understanding and minimizes the inclusion of details students are unlikely to use. The discussion of elements begins with survey chapters focused on the main groups, while later chapters cover the elements in greater detail. Each chapter opens with narrative introductions and includes figures, tables, and end-of-chapter problem sets. This text is ideal for advanced undergraduate and graduate-level students enrolled in the inorganic chemistry course. The text may also be suitable for biochemistry, medicinal chemistry, and other professionals who wish to learn more about this subject are.

  • The Practice of Medicinal Chemistry

    • 3rd Edition
    • Camille Georges Wermuth
    • English
    The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 35
    • Atta-ur Rahman
    • English
    This volume presents frontier reviews of recent developments in bioactive natural products in cutting-edge areas by eminent experts in their respective fields. It is an essential addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 96
    • Alan R. Katritzky
    • English
    The definitive serial in the field -- since 1960.

  • Organic Structure Determination Using 2-D NMR Spectroscopy

    A Problem-Based Approach
    • 1st Edition
    • Jeffrey H. Simpson
    • English
    Organic Structure Determination Using 2-D NMR Spectroscopy is a primary text for a course in NMR techniques, with the goal to learn to identify organic molecular structure. It presents strategies for assigning resonances to known structures and for deducing structures of unknown organic molecules based on their NMR spectra.It contains 20 known and 20 unknown structure determination problems and features a supporting website from which instructors can download the structures of the unknowns in selected chapters, digital versions of all figures, and raw data sets for processing. Many other books describe the methods used, but none offer a large number of problems. Instructors at universities and colleges are forced to cobble together problems from a wide range of sources. The fragmentary approach to assembling course materials has a negative impact on course continuity and thus adversely impacts student retention.This book will stand as a single source to which instructors and students can go to obtain a comprehensive compendium of NMR problems of varying difficulty.

  • Evolutionary Essays

    A Thermodynamic Interpretation of the Evolution
    • 1st Edition
    • Sven Erik Jørgensen
    • English
    Evolution is nature’s most fascinating process, the possibility given sufficient time to combine simple inorganic compounds to more and more complex biochemical compounds, which make up more and more complex organisms. It is therefore crucial in our effort to understand the evolution to see it from as many different angles as possible. This books draw an image of evolution from the thermodynamic viewpoint, which gives new and surprising insights into the processes and mechanisms that have driven evolution. This new thermodynamic interpretation has made it possible to quantify the various steps of evolution and to show that evolution has followed an exponential growth curve.

  • Thermophysical Properties of Chemicals and Hydrocarbons

    • 1st Edition
    • Carl L. Yaws
    • English
    Carl Yaws here presents over 7,800 organic and inorganic chemicals, and hydrocarbons. Spanning gases, liquids and solids, and covering all critical properties (including acentric factor, density, enthalpy of vaporization, and surface tension), this volume represents more properties on more chemicals than any single work of its kind, from C1 to C100 organics and Ac to Zr inorganics. Designed and formatted for field, lab or classroom usage, it gives the reader unparalleled access to invaluable data.

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