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TDP-43 and Neurodegeneration

From Bench to Bedside

  • 1st Edition - October 23, 2021
  • Latest edition
  • Editors: Vijay Kumar, Manoj Kumar Jaiswal
  • Language: English

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (F… Read more

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Description

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.

Key features

  • Reviews TDP-43 structure, folding, function, and pathology
  • Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases
  • Presents a systems and precision biology perspective of TDP-43
  • Discusses therapeutics of TDP-43 proteinopathies
  • Translates bench research to application bedside

Readership

Researchers, advanced graduate students, and clinicians interested in translational neuroscience, neurobiology and neuropathology

Table of contents

1. TDP-43: Past, Present and Future

2. Structural studies of TDP-43

3. TDP-43 mutations and Amyotrophic Lateral Sclerosis

4. Post translational modifications of TDP-43

5. TDP-43 and Autophagy

6. TDP-43 and Alzheimer Disease

7. TDP-43 and Stress granules

8. Repeat domains in TDP-43

8. Systems Biology of TDP-43

9. Animal models of TDP-43 in ALS

10. Therapeutic modulations of TDP-43

Product details

  • Edition: 1
  • Latest edition
  • Published: October 27, 2021
  • Language: English

About the editors

VK

Vijay Kumar

Vijay Kumar, PhD, is an assistant professor at Amity University. He earned his PhD in Biophysics from AIIMS, New Delhi, and completed a postdoctoral fellowship at UMass Medical School, focusing on folding and aggregation of proteins such as SOD1 and TDP-43 implicated in motor neuron disease, ALS, and FTD. Returning to India, he served as Principal Investigator under the DST-SERB Young Scientist Scheme at Jamia Millia Islamia. His current research centers on protein folding, misfolding, and aggregation, and the role of toxic RNA species in neurodegenerative diseases. He is a member of the Protein Society, Indian Biophysical Society, Indian Academy of Neurosciences, and the International Society for Neurochemistry. He has held fellowships from CSIR and a DAAD fellowship in Germany.
Affiliations and expertise
Amity University

MJ

Manoj Kumar Jaiswal

Manoj Kumar Jaiswal, Ph.D., has been non-tenure track faculty (Instructor) in the Department of Psychiatry at Icahn School of Medicine at Mount Sinai, NY, since 2017. He obtained PhD degree at the Georg-August University, Goettingen, Germany, and postdoctoral training at MIT, Cambridge, MA and CNRM, Bethesda, MD. More recently, Dr. Jaiswal is a Research Scientist in the Department of Psychiatry at the Columbia University Medical Center in NY. His current research focuses on studies related to neurodegeneration in ALS, motor neuron disease, brain Injury, and psychiatric disorders. He is a recipient of an NIH Career Development Award and was appointed as a Career Development Fellow and later a Senior Research Fellow at the CNRM in Bethesda, MD where he studied molecular mechanisms of Traumatic Brain Injury (TBI) using 2-photon in-vivo imaging and 3-D microscopy. Dr. Jaiswal, has received numerous honors and awards, including scholarships and poster awards, and was invited to present lectures and seminars. He is a member of Society for Neuroscience (SfN) and the National Neurotrauma Society (NNS). He has been the Principal Investigator of a National Institute of Health/DoD: Pilot Project entitled: “Balance between inhibition and excitation and the vascular trauma in sensory barrel cortex after TBI: in-vivo imaging approach”. He is a reviewer and editor for many journals, including Scientific Reports, Annals of Neurology and Frontiers in Cellular Neuroscience. He has authored numerous articles, book and book chapters on Amyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease and Psychiatric Disorders.
Affiliations and expertise
Department of Psychiatry, Icahn School of Medicine at Mount Sina, New York, NY, USA

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