The Autoimmune Diseases
- 4th Edition - March 27, 2006
- Editors: M. Eric Gershwin, George C. Tsokos
- Language: English
Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened.… Read more
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Description
Description
Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.
Key features
Key features
New to This Edition:
* Tissue-specific interventions to arrest or "cure" autoimmune disease
* Bone marrow eradication and replacement
* Both basic science and clinical medicine is covered
* Boxed points to emphasize key features of each chapter
* Tissue-specific interventions to arrest or "cure" autoimmune disease
* Bone marrow eradication and replacement
* Both basic science and clinical medicine is covered
* Boxed points to emphasize key features of each chapter
Readership
Readership
Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases
Table of contents
Table of contents
IMMUNOLOGIC BASIS OF AUTOIMMUNITY
AUTOIMMUNITY: A HISTORY OF THE EARLY STRUGGLE FOR RECOGNITION
STRUCTURAL AND FUNCTIONAL ASPECTS OF THE INNATE AND ADAPTIVE SYSTEMS OF IMMUNITY
GENERAL FEATURES OF THE AUTOIMMUNE DISEASES
ANTIGEN PRESENTATION, DENDRITIC CELLS AND AUTOIMMUNITY
MHC COMPLEX AND AUTOIMMUNITY
T CELLS AND AUTOIMMUNITY
ROLE OF TH1 AND TH2 CELLS IN AUTOIMMUNITY
TOLERANCE AND AUTOIMMUNITY – T CELLS
REGULATORY T CELLS
PEPTIDE-BASED INSTRUCTION OF SUPPRESSOR COMMITMENT IN NAÏVE T CELLS
B CELLS AND AUTOIMMUNITY
MEMORY B CELL DEVELOPMENT
TOLERANCE AND AUTOIMMUNITY – B CELLS
GENERATION OF T CELL ANTIGENIC DETERMINANTS IN AUTOIMMUNITY AND THEIR RECOGNITION
APOPTOTIC CELLS AS A SOURCE OF AUTOANTIGENS
EFFECTOR MECHANISMS OF AUTOIMMUNITY: ANTIBODIES, IMMUNE COMPLEXES
FUNCTIONAL EFFECTS OF ANTIBODIES
ADHESION MOLECULES AND CHEMOATTRACTANTS: RELEVANCE TO THE PATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASES
SIGNALING PATHWAYS IN T AND B LYMPHOCYTES
GENETICS AND AUTOIMMUNITY: ROLE OF HLA IN AUTOIMMUNE DISEASES
GENETICS AND AUTOIMMUNITY - NON-MHC
INFECTIONS, IMMUNITY AND AUTOIMMUNITY
NON-INFECTIOUS ENVIRONMENTAL AGENTS AND AUTOIMMUNITY
VACCINES AND AUTOIMMUNE DISEASES
SEX, PREGNANCY AND AUTOIMMUNITY
MULTISYSTEM DISEASES
ANIMAL MODELS FOR AUTOIMMUNE DISEASE
SYSTEMIC LUPUS ERYTHEMATOSUS, CHRONIC CUTANEOUS LUPUS,
AND MIXED CONNECTIVE TISSUE DISEASE
THE IMMUNOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS
SYSTEMIC SCLEROSIS- SCLERODERMA
ANTIPHOSPHOLIPID SYNDROME
SJÖGREN’S SYNDROME (AUTOIMMUNE EPITHELITIS)
RHEUM ATOID ARTHRITIS
SPONDYLOARTHRITIS AND CHRONIC IDIOPATHIC ARTHROPATHIES
POLYMYOSITIS AND DERMATOMYOSITIS*
ENDOCRINE AND RELATED DISEASES
THYROID DISEASE
TYPE 1 DIABETES
ADRENALITIS
POLYENDOCRINE SYNDROMES
AUTOIMMUNE GASTRITIS AND PERNICIOUS ANEMIA
AUTOIMMUNE HYPOPHYSITIS
BLOOD DISEASES
AUTOIMMUNE HEMOLYTIC ANEMIA
AUTOIMMUNE THROMBOCYTOPENIC PURPURA
AUTOIMMUNE NEUTROPENIA
ACQUIRED APLASTIC ANEMIA
CLOTTING DISORDERS
NEUROLOGIC DISEASES
MULTIPLE SCLEROSIS
PERIPHERAL NEUROPATHIES
MYASTHENIA GRAVIS AND ANTI-RECEPTOR DISEASES OF THE NERVOUS SYSTEM
UVEITIS
INNER EAR DISEASE
INTESTINAL, HEPATIC, AND PANCREATIC DISEASES
CELIAC DISEASE
INFLAMMATORY BOWEL DISEASES: ULCERATIVE COLITIS AND CROHN’S DISEASE
CHRONIC HEPATITIS
PRIMARY BILIARY CIRRHOSIS
PRIMARY SCLEROSING CHOLANGITIS
AUTOIMMUNE PANCREATITIS
CUTANEOUS DISEASES
BULLOUS SKIN DISEASES: PEMPHIGUS VULGARIS AND OTHER TYPES OF PEMPHIGUS
NON-BULLOUS SKIN DISEASES: ALOPECIA, PSORIASIS, VITILIGO, URTICARIA
UROGENITAL DISEASES
KIDNEY: GOODPASTURE’S DISEASE, LUPUS NEPHRITIS, ANCA-ASSOCIATED GLOMERULONEPHRITIS
AUTOIMMUNE ORCHITIS AND MALE INFERTILITY
OOPHORITIS
CARDIOVASCULAR AND PULMONARY DISEASES
RHEUMATIC HEART DISEASE
MYOCARDITIS AND DILATED CARDIOMYOPATHY
ATHEROSCLEROSIS: AUTOIMMUNITY TO HEAT-SHOCK PROTEINS
NECROTIZING ARTERITIS AND SMALL VESSEL VASCULITIS
VASCULITIS
IDIOPATHIC BRONCHIOLITIS OBLITERANS, IDIOPATHIC PULMONARY FIBROSIS, AND THE AUTOIMMUNE DISORDERS OF THE LUNG
NEOPLASIA AND AUTOIMMUNITY
PARANEOPLASTIC DISEASES – AUTOIMMUNE RESPONSES TO TUMOR ANTIGENS
LYMPHOMA AND AUTOIMMUNE DISEASE
APOPTOSIS AND AUTOIMMUNITY -
LYMPHOPROLIFERATIVE SYNDROMES
MISCELLANEOUS
CAMEOS
DIAGNOSIS, PREVENTION, AND THERAPY
AUTOANTIBODY ASSAYS, TESTING AND STANDARDIZATION
T-CELL ASSAYS
PREDICTION OF AUTOIMMUNE DISEASE
THE PREVENTION OF AUTOIMMUNE DISEASE: TYPE 1 DIABETES AS A PARADIGM
EMERGING THERAPIES IN AUTOIMMUNE DISEASES
EPILOGUE - ADVOCATUS DIABOLI
AUTOIMMUNITY: A HISTORY OF THE EARLY STRUGGLE FOR RECOGNITION
STRUCTURAL AND FUNCTIONAL ASPECTS OF THE INNATE AND ADAPTIVE SYSTEMS OF IMMUNITY
GENERAL FEATURES OF THE AUTOIMMUNE DISEASES
ANTIGEN PRESENTATION, DENDRITIC CELLS AND AUTOIMMUNITY
MHC COMPLEX AND AUTOIMMUNITY
T CELLS AND AUTOIMMUNITY
ROLE OF TH1 AND TH2 CELLS IN AUTOIMMUNITY
TOLERANCE AND AUTOIMMUNITY – T CELLS
REGULATORY T CELLS
PEPTIDE-BASED INSTRUCTION OF SUPPRESSOR COMMITMENT IN NAÏVE T CELLS
B CELLS AND AUTOIMMUNITY
MEMORY B CELL DEVELOPMENT
TOLERANCE AND AUTOIMMUNITY – B CELLS
GENERATION OF T CELL ANTIGENIC DETERMINANTS IN AUTOIMMUNITY AND THEIR RECOGNITION
APOPTOTIC CELLS AS A SOURCE OF AUTOANTIGENS
EFFECTOR MECHANISMS OF AUTOIMMUNITY: ANTIBODIES, IMMUNE COMPLEXES
FUNCTIONAL EFFECTS OF ANTIBODIES
ADHESION MOLECULES AND CHEMOATTRACTANTS: RELEVANCE TO THE PATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASES
SIGNALING PATHWAYS IN T AND B LYMPHOCYTES
GENETICS AND AUTOIMMUNITY: ROLE OF HLA IN AUTOIMMUNE DISEASES
GENETICS AND AUTOIMMUNITY - NON-MHC
INFECTIONS, IMMUNITY AND AUTOIMMUNITY
NON-INFECTIOUS ENVIRONMENTAL AGENTS AND AUTOIMMUNITY
VACCINES AND AUTOIMMUNE DISEASES
SEX, PREGNANCY AND AUTOIMMUNITY
MULTISYSTEM DISEASES
ANIMAL MODELS FOR AUTOIMMUNE DISEASE
SYSTEMIC LUPUS ERYTHEMATOSUS, CHRONIC CUTANEOUS LUPUS,
AND MIXED CONNECTIVE TISSUE DISEASE
THE IMMUNOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS
SYSTEMIC SCLEROSIS- SCLERODERMA
ANTIPHOSPHOLIPID SYNDROME
SJÖGREN’S SYNDROME (AUTOIMMUNE EPITHELITIS)
RHEUM ATOID ARTHRITIS
SPONDYLOARTHRITIS AND CHRONIC IDIOPATHIC ARTHROPATHIES
POLYMYOSITIS AND DERMATOMYOSITIS*
ENDOCRINE AND RELATED DISEASES
THYROID DISEASE
TYPE 1 DIABETES
ADRENALITIS
POLYENDOCRINE SYNDROMES
AUTOIMMUNE GASTRITIS AND PERNICIOUS ANEMIA
AUTOIMMUNE HYPOPHYSITIS
BLOOD DISEASES
AUTOIMMUNE HEMOLYTIC ANEMIA
AUTOIMMUNE THROMBOCYTOPENIC PURPURA
AUTOIMMUNE NEUTROPENIA
ACQUIRED APLASTIC ANEMIA
CLOTTING DISORDERS
NEUROLOGIC DISEASES
MULTIPLE SCLEROSIS
PERIPHERAL NEUROPATHIES
MYASTHENIA GRAVIS AND ANTI-RECEPTOR DISEASES OF THE NERVOUS SYSTEM
UVEITIS
INNER EAR DISEASE
INTESTINAL, HEPATIC, AND PANCREATIC DISEASES
CELIAC DISEASE
INFLAMMATORY BOWEL DISEASES: ULCERATIVE COLITIS AND CROHN’S DISEASE
CHRONIC HEPATITIS
PRIMARY BILIARY CIRRHOSIS
PRIMARY SCLEROSING CHOLANGITIS
AUTOIMMUNE PANCREATITIS
CUTANEOUS DISEASES
BULLOUS SKIN DISEASES: PEMPHIGUS VULGARIS AND OTHER TYPES OF PEMPHIGUS
NON-BULLOUS SKIN DISEASES: ALOPECIA, PSORIASIS, VITILIGO, URTICARIA
UROGENITAL DISEASES
KIDNEY: GOODPASTURE’S DISEASE, LUPUS NEPHRITIS, ANCA-ASSOCIATED GLOMERULONEPHRITIS
AUTOIMMUNE ORCHITIS AND MALE INFERTILITY
OOPHORITIS
CARDIOVASCULAR AND PULMONARY DISEASES
RHEUMATIC HEART DISEASE
MYOCARDITIS AND DILATED CARDIOMYOPATHY
ATHEROSCLEROSIS: AUTOIMMUNITY TO HEAT-SHOCK PROTEINS
NECROTIZING ARTERITIS AND SMALL VESSEL VASCULITIS
VASCULITIS
IDIOPATHIC BRONCHIOLITIS OBLITERANS, IDIOPATHIC PULMONARY FIBROSIS, AND THE AUTOIMMUNE DISORDERS OF THE LUNG
NEOPLASIA AND AUTOIMMUNITY
PARANEOPLASTIC DISEASES – AUTOIMMUNE RESPONSES TO TUMOR ANTIGENS
LYMPHOMA AND AUTOIMMUNE DISEASE
APOPTOSIS AND AUTOIMMUNITY -
LYMPHOPROLIFERATIVE SYNDROMES
MISCELLANEOUS
CAMEOS
DIAGNOSIS, PREVENTION, AND THERAPY
AUTOANTIBODY ASSAYS, TESTING AND STANDARDIZATION
T-CELL ASSAYS
PREDICTION OF AUTOIMMUNE DISEASE
THE PREVENTION OF AUTOIMMUNE DISEASE: TYPE 1 DIABETES AS A PARADIGM
EMERGING THERAPIES IN AUTOIMMUNE DISEASES
EPILOGUE - ADVOCATUS DIABOLI
Review quotes
Review quotes
"...edited by Noel R. Rose and Ian R. Mackay, widely recognized experts in autoimmunity and its pathophysiological and clinical aspects...This thoughtfully updated new edition takes into consideration important developments in basic and clinical science...This book will be a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune diseases, to scientists who want to follow developments in the field, and to all those who enjoyed the previous edition."—Martha M. Eibl, M.D. for NEW ENGLAND JOURNAL OF MEDICINE (Jan 2006)
Product details
Product details
- Edition: 4
- Published: March 27, 2006
- Language: English
About the editors
About the editors
MG
M. Eric Gershwin
M. Eric Gershwin, MD, is chief of the division of rheumatology, allergy, and clinical immunology at the University of California at Davis. Gershwin is currently working to further understand the molecular basis of immune regulation in autoimmunity. He also studies the molecular-genetic basis of autoimmune liver disease. Gershwin is interested in the molecular and genetics tools being utilized to study the genes that contribute to a patient's susceptibility to lupus and the cellular and subcellular mechanisms that lead to immune disease.
Affiliations and expertise
Distinguished Professor of Medicine, The Jack and Donald Chia Professor of Medicine and Chief, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USAGT
George C. Tsokos
George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.
Affiliations and expertise
Professor of Medicine, Harvard Medical School and Chief of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, USAView book on ScienceDirect
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