Skip to main content
Elsevier

The Molecular and Cellular Basis of Neurodegenerative Diseases

Underlying Mechanisms

  • 1st Edition - March 29, 2018
  • Latest edition
  • Editor: Michael S. Wolfe
  • Language: English

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodege… Read more

Description

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common.

This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

Key features

  • Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features
  • Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration
  • Details features, advantages and limitations of animal models, as well as prospects for therapeutic development
  • Authored by internationally recognized leaders in the field
  • Includes illustrations that help clarify and consolidate complex concepts

Readership

Graduate students in biological and biomedical sciences, neuroscientists, neurobiologists, neuropathologists, biological psychiatrists, post-doctoral fellows, researchers

Table of contents

1. General Overview
Michael S. Wolfe

2. Prion Diseases
Robert C.C. Mercer, Alex J. McDonald, Erin Bove-Fenderson, Cheng Fang, Bei Wu and David Harris

3. Alzheimer’s disease: towards a quantitative biological approach in describing its natural history and underlying mechanisms
Colin Masters

4. Neurodegeneration and the ordered assembly of Tau
Michael Goedert

5. ALS and Other TDP43 Proteinopathies
Christopher Shaw and Jorge Gomez-Deza

6. Parkinson’s Disease and Other Synucleinopathies
Mark R. Cookson

7. Huntington’s Disease and Other Polyglutamine Disorders
Albert R. La Spada and Audrey Dickey

8. Prion-like propagation in Neurodegenerative Diseases
Patrik Brundin, Veerle Baekelandt and Wouter Peelaerts

9. Neurodegenerative Diseases as Protein Folding Disorders
Jack Mathew Webster

10. Heat shock proteins and protein quality control in Alzheimer's disease
Fred van Leeuwen and Harm H. Kampinga

11. Neurodegenerative Diseases and Autophagy
David C. Rubinsztein

12. Neurodegenerative Diseases and Axonal Transport
Larry Goldstein and Utpal Das

13. Mitochondrial Function and Neurodegenerative Diseases
Russell Swerdlow

14. Neurodegenerative Diseases and Non-cell autonomous toxicity
Azad Bonni

15. Neurodegenerative Diseases and RNA-mediated toxicity
Tiffany Todd and Leonard Petrucelli

16. Neuroinflammation in Age-Related Neurodegenerative Diseases
Kathryn MacPherson, Maria Elizabeth de Sousa Rodrigues, Amarallys F. Cintron and Malú G. Tansey

17. Neurodegenerative Diseases and the Aging Brain
Stephen Kenneth Godin, Jinsoo Seo, and Li-Huei Tsai

Product details

  • Edition: 1
  • Latest edition
  • Published: April 4, 2018
  • Language: English

About the editor

MW

Michael S. Wolfe

Michael S. Wolfe is the Mathias P. Mertes Professor of Medicinal Chemistry at the University of Kansas. He received his B.S. in chemistry in 1984 from the Philadelphia College of Pharmacy and Science and Ph.D. in medicinal chemistry in 1990 from the University of Kansas. After postdoctoral stints at the University of Kansas (medicinal chemistry) and the NIH (cell biology), he joined the faculty of the University of Tennessee in Memphis in 1994. In 1999, he joined the faculty at Brigham and Women’s Hospital and Harvard Medical School in Boston, becoming Professor of Neurology in 2008. Prof. Wolfe’s work has focused on understanding the molecular basis of Alzheimer’s disease and related disorders, and identifying effective approaches for pharmacological intervention. Awards for his work include the Sato Memorial International Award in bioorganic and medicinal chemistry from the Pharmaceutical Society of Japan (2003), the MetLife Award for Biomedical Research (2008), a Zenith Fellows Award from the Alzheimer’s Association (2008), and the Potamkin Prize from the American Academy of Neurology (2009).
Affiliations and expertise
Professor of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

View book on ScienceDirect

Read The Molecular and Cellular Basis of Neurodegenerative Diseases on ScienceDirect