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Elsevier

The Neuroscience of Dementia

  • 1st Edition - September 23, 2020
  • Latest edition
  • Editors: Colin R. Martin, Victor R. Preedy
  • Language: English

The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer’s disease, Lewy body d… Read more

Description

The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia

Readership

Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors

Table of contents

DIAGNOSIS AND MANAGEMENT IN DEMENTIA

I. Dementia: Introductory Chapters and Setting the Scene1. Mixed dementia: an overview Jaqcues J. De Reuck2. Vascular dementia: an overviewVirginia Cipollini3. Small vessel disease and dementiaFrancesco Arba4. Linking Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementiaPhilippe Couratier5. Mortality in dementia: linking in deliriumThiago Silva6. Midlife diabetes and the risk of dementia- understanding the linkSean Kennelly and Adam H. Dyer7. Gait and Alzheimer's disease /Gait and dementia Michele Linda Callisaya8. Hypertension and dementiaRebecca F. Gottesman9. Genetics of dementia: focus on Alzheimer’s diseaseFrancesca Fernandez10. Clinical and pathological phenotypes in autosomal dominant frontotemporal dementiaInnocenzo Rainero11. Risk factors in dementia: genetic and nongeneticEvangelos Evangelou12. Lipidomics and biomarker in Alzheimer’s diseasePerminder S. Sachdev and UNSW13. The 5xFAD mouse model of Alzheimer’s diseaseSylvie Claeysen

II. Biomarkers, Psychometric Instruments And Diagnosis 14. Use of cerebrospinal fluid in diagnosis of dementiaAngelo Nuti15. Salivary biomarkers in Alzheimer’s diseaseFrancesca Fernandez16. Diacylglycerols as biomarkers in dementiaPaul Wood17. Butyrylcholinesterase (BChE) as a biomarker in Alzheimer’s diseaseSultan Darvesh18. Blood brain-derived neurotrophic factor as a biomarker of Alzheimers diseaseMarta Balietti19. Methods of amyloid PET Imaging and its applications to Alzheimer’s disease spectrumShizuo Hatashita Sr.20. Applications of diffusion-weighted imaging (DWI) Tractography and Alzheimer’s diseaseNicola Amoroso21. Transcranial Magnetic stimulation and diagnostic applications to dementiasMatthew Kiernan and Thanuja Dharmasada22. Retinal imaging and dementia as a diagnostic toolCarol Y. Cheung23. The prediction of Alzheimer’s diseaseAthanasios Alexou24. Addenbrooke's Cognitive ExaminationJordi A. Matias-Guiu25. The Montreal Cognitive Assessment (MoCA) and applications to dementiaAndrea Bosco26. ALBA Screening Instrument (ASI) and applications to dementiaAngel Golimstok27. The Quick Mild Cognitive Impairment (Qmci) screen and applications to dementiaRoger Clarnette28. Assessment of activities of daily living (ADL) applied to dementiaPatricia De Vriendt

III. Pharmacological Treatments For Dementia29. Cholinesterase inhibitors in dementias: an overviewPatrizia Mecocci30. Choline-containing phospholipids and treatment of adult-onset dementia disordersFrancesco Amenta31. Donepezil usage: a focused reviewFrancesco Amenta32. Memantine: a focused reviewSergio del Rio Sancho33. The benefits of calcium channel blockers for the therapy of dementia L. Bergantin34. Pitfalls for pharmacotherapeutic trials in dementiaT. Mueller35. All-trans retinoic acid in Alzheimer’s diseaseSiamak Beheshti36. Dementias and usage of NMDA receptor antagonistsBrianna E. Glynn-Servedio37. Dementia and bladder dysfunction: a focus on treatments with anticholinergics　Ryuji Sakakibara38. Linking astrocytes' exosomes to Alzheimer's pathogenesis and therapyAnna Chiarini39. Changing the fate: therapeutic mechanisms focus on the switch of beta-amyloid precursor protein (APP)processingKristina Endres40. Acetylcholinesterase inhibitory agents in plants and application to dementia: Alzheimers DiseaseWillian Orlando Castillo-Ordonez41. Removal of blood amyloid as a safety strategyNobuya Kitaguchi

IV. Non-Pharmacological Treatments and Procedures

42. Caring for people with Dementia in the Acute HospitalR. Briggs and Sean Kennelly43. Environmental enrichment in dementiaKimberley Stuart44. Music therapy in dementiaAlfredo Raglio and Lapo Attardo45. Aromatherapy in dementiaG. Bagetta and Damiana Scuteri46. Dancing in dementiaLee-Fay Low and Kathryn Dovey47. Hypoxic-hyperoxic training and dementiaMartin Burtscher48. Linking amyloid and depression in dementia: effects of treatments by non-drug meansAkihiko Nunomura49. Regional dementia care networksFranziska laporte Uribe50. Cognitive behavioural therapy (CBT) use in Alzheimer’s diseaseAlicia Ann Walf51. Maximizing cognition in Mild Cognitive Impairment and early-stage dementiaBridget Regan52. Exercise, cognitive creativity, and dementiaPaul D. Loprinzi53. Linking care staff, person-focused communications and dementiasMarie Y. Savundranayagam

GENETICS, NEUROLOGY, BEHAVIOR, AND DIET IN DEMENTIA

I. Genetics, Molecular and Cellular Biology1. The genetics of Alzheimer’s disease: a focus on the neuron navigator 2 geneKesheng Wang and Chun Xu2. Interlinking polymorphisms, estrogens and Alzheimer’s diseaseY. Q. Song3. Linking EEGs, Alzheimer’s disease and the Phosphatidylinositol binding clathrin assembly protein (PICALM) geneNatalya Ponomareva4. CD36 gene polymorphism and Alzheimer’s diseaseO. Sery5. Genetic contributions to sporadic frontotemporal dementiaJennifer S. Yokoyama and Jessie S. Carr6. Dementia and CYP2D6 polymorphismsP. Caramelli7. A1 purinergic receptor gene expression in dementiaGuadalupe Maria Garcia-Alcocer8. Molecular aspects of metallothionein-1 in dememtiasJuan Hidalgo9. MicroRNAs in Alzheimer's diseaseUrszula Wojda10. Oxidative stress and neurons in dementiaElena Miranda11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer's disease neurodegenerationNibaldo C. Inestrosa and Juan Zolezzi12. Wnt Signalling and dementiaA.Angeles Martin-Requero Sr.13. Linking PKC, PKClambda/I and Alzheimer’s diseaseRobert V. Farese14. Linking histone deacetylases, phosphodiesterase 5 and novel treatments Alzheimer’s diseaseAna Garcia-Osta15. Linking Nrf2 and Alzheimers diseaseJoshua Park16. Role of alpha- and beta-secretase in Alzheimer’s diseaseKristina Endres17. Methylation analysis of DNA in Alzheimer’s diseaseFabio Coppedè18. The signalosome malfunctions in age-associated neuropathologiesRaquel Marin19. ILEI/FAM3C in Alzheimer’s diseaseMasaki Nishimura20. Amylin and Alzheimer’s diseaseJack H. Jhamandas21. Mammalian target of rapamycin (mTOR) complexes: Regulation and Alzheimer's diseaseHenry Querfurth and Han Kyu Lee22. Mammalian target of rapamycin (mTOR) complexes: Protein synthesis and autophagy, Parkinsons Disease, Amyotrophic Lateral Sclerosis and frontotemporal dementiaHenry Querfurth and Han Kyu Lee23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammationD. Walker

II. Neurological, Physiological and Imaging

24. Hippocampal atrophy and dementiaHiroshi Yao25. Inflammation and insulin resistance in AD: partners in crimeD. Frenkel26. Neuronal susceptibility to hypoxia in Alzheimer diseaseLaura Calza27. Neuropeptides and Neurolipids: what they are and how they relate to Alzheimers diseaseRafael Rodriguez28. Brain receptors in Alzheimer’s diseaseRafael Rodriguez29. Abeta42-alpha7-like nicotinic acetylcholine receptors and Alzheimer’s diseaseHoau-Yan Wang30. Synaptosomal bioenergetics in Alzheimer’s diseaseLaura Morelli31. Limitations of amyloid-PET imagingDavid Weidman32. Linking Gradient Echo Plural Contrast Imaging (GEPCI) Metrics of Tissue Microstructure with Alzheimer Dmitry A. Yablonskiy33. Hypertensive disorders in pregnancy and later dementiaEllika Andolf34. Sleep architecture and the development of clinical dementiaMatthew Paul Pase

III. Behaviour and Psychopathology

35. An overview of behavioural and psychiatric symptoms of dementiaDorothy M. Grillo36. Delirium superimposed on dementia: from diagnosis to treatment Alessandro Morandi37. Self-Consciousness Deficits in dementiaE. Arroyo-Anllo38. Attention impairements, novel images and Alzheimer’s diseaseKrista Lanctot39. Frontal Lobe Syndrome and DementiasPetronilla Battista40. The stigma of dementia Albert Aboseif and Benjamin K.P. Woo41. Delusions in dementiasFrancesco Panza42. Linking motor speech function and dementia Adam P. Vogel and Matthew Poole43. Spatial Navigation and Alzheimer’s diseaseBenjamin Clark44. Violence and dementiaG. Cipriani and Sabrina Danti45. Caregiver depression in dementiaSheung Tak Cheng

IV. Diet, Nutrition and Environment 46. Nutritional status in dementiaKyung Ja Chang47. Selenium and Alzheimer’s diseaseBárbara R. Cardoso48. Linking adiponectin and obesity in dementia M. Bednarska-Makaruk49. The gut microbiome in Alzheimer's DiseaseKristina Endres50. (-)-epigallocatechin-3-gallate (EGCG) and Alzheimer diseaseRafael de la Torre and Laura Xicota51. Cadmium and Alzheimer’s diseaseSung Kyun Park

V. Models And Modelling In Dementia52. Alzheimer's model 5xFAD mice as a model and applications to dementiaYasuhisa Ano53. Use of 192 IgG-saporin as a model of dementia and its applicationJin Woo Chang and Yong-sook Park54. Abeta1-42 oligomer animal model of dementiaJosiane BudniResourcesRajkumar Rajendram

Review quotes

"This book is a must-have for anyone dealing with dementia in their clinical practice or research." —Doody

Product details

  • Edition: 1
  • Latest edition
  • Published: September 23, 2020
  • Language: English

About the editors

CM

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

VP

Victor R. Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.
Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK