Transfusion Medicine and Hemostasis

TABLE OF CONTENTS:I. Blood Banking and Transfusion Medicine A. Introduction 1. BLOOD BANKING AND TRANSFUSION MEDICINE – THE FIELD, THE DISCIPLINE AND THE INDUSTRYCHRISTOPHER D. HILLYER, MD 2. A BRIEF HISTORY OF BLOOD TRANSFUSIONALFRED J. GRINDON, MD 3. INTRODUCTION TO QUALITY SYSTEMS and QUALITY MANAGEMENT JIMMIE L. EVANS AND CHRISTOPHER D. HILLYER, MDB. Blood Banking 4. THE ROLE OF THE PHYSICIAN IN THE BLOOD CENTERCHRISTOPHER D. HILLYER, MDa. Donation process5. BLOOD DONOR, DONATION PROCESS AND TECHNICAL ASPECTS OF BLOOD COLLECTIONKRISTA L. HILLYER, MD 6. APHERESIS BLOOD COMPONENT COLLECTIONS KRISTA L. HILLYER, MD 7. RECIPIENT-SPECIFIC BLOOD DONATIONKRISTA L. HILLYER, MD 8. ADVERSE DONOR REACTIONSKRISTA L. HILLYER, MD b. Component manufacturing9. COMPONENT PREPARATION AND MANUFACTURINGCOURTNEY E. GREENE AND CHRISTOPHER D. HILLYER, MDc. Donor testing10. SEROLOGIC TESTING OF DONOR PRODUCTSKRISTA L. HILLYER, MD 11. OVERVIEW OF INFECTIOUS DISEASE TESTINGCHRISTOPHER D. HILLYER, MD 12. HIV SCREENING OF DONOR PRODUCTSKRISTA L. HILLYER, MD 13. HEPATITIS B SCREENING OF DONOR PRODUCTKRISTA L. HILLYER, MD 14. HEPATITIS C SCREENING OF DONOR PRODUCTKRISTA L. HILLYER, MD 15. WNV SCREENING OF DONOR PRODUCTKRISTA L. HILLYER, MD 16. SYPHILIS, HTLV, AND CHAGAS TESTING OF DONOR PRODUCTCHELSEA A. SHEPPARD, MD AND KRISTA L. HILLYER, MD17. BACTERIAL DETECTION METHODSBETH H. SHAZ, MDC. Transfusion Medicine 18. THE ROLE OF THE TRANSFUSION SERVICE PHYSICIANBETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MDa. Testing19. PRETRANSFUSION TESTINGBETH H. SHAZ, MD20. ANTIBODY IDENTIFICATIONBETH H. SHAZ, MD21. DIRECT ANTIGLOBULIN TESTBETH H. SHAZ, MDb. Blood groups22. ABO AND H BLOOD GROUP SYSTEMSBETH H. SHAZ, MD23. RH BLOOD GROUP SYSTEMBETH H. SHAZ, MD24. KELL AND KIDD BLOOD GROUP SYSTEMSBETH H. SHAZ, MD25. MNS AND DUFFY BLOOD GROUP SYSTEMSBETH H. SHAZ, MD JOHN D. ROBACK, MD, PhD26. LEWIS,I , AND P BLOOD GROUP SYSTEMSBETH H. SHAZ, MD27. OTHER BLOOD GROUP SYSTEMS, COLLECTIONS, AND ANTIGENSBETH H. SHAZ, MDc. Blood products28. RED BLOOD CELLS AND RELATED PRODUCTSCHRISTOPHER D. HILLYER, MD29. PLASMA PRODUCTSCASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD30. PLATELET PRODUCTSBETH H. SHAZ, MD31. CRYOPRECIPITATEBETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD32. GRANULOCYTE PRODUCTSCHRISTOPHER D. HILLYER, MD AND LAWRENCE B. FIALCOW, DO 33. ALBUMIN AND RELATED PRODUCTSANNE M. WINKLER, MD AND BETH H. SHAZ, MD 34. HUMAN IMMUNOGLOBULIN PREPARATIONSBETH H. SHAZ, MD 35. RH IMMUNE GLOBULINBETH H. SHAZ, MD d.Product modifications36. IRRADIATION OF BLOOD PRODUCTSBETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 37. LEUKOREDUCTION OF BLOOD PRODUCTSJAMES C. ZIMRING, MD, PhD 38. CMV- SAFE BLOOD PRODUCTSJOHN D. ROBACK, MD, PhD 39. FROZEN BLOOD PRODUCTSCASSSANDRA D. JOSEPHSON, MD and BETH H. SHAZ, MD40. WASHED BLOOD PRODUCTSCASSSANDRA D. JOSEPHSON, MD and BETH H. SHAZ, MD41. VOLUME REDUCED BLOOD PRODUCTSCASSSANDRA D. JOSEPHSON, MD e. Specific clinical settings42. NEONATAL AND PEDIATRIC TRANSFUSION MEDICINEJEANNE E. HENDRICKSON, MD AND CASSSANDRA D. JOSEPHSON, MD 43. PERINATAL TRANSFUSION MEDICINEBETH H. SHAZ, MD 44. AUTOIMMUNE HEMOLYTIC ANEMIASBETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 45. TRANSFUSION MANAGEMENT IN PATIENTS WITH HEMOGLOBINOPATHIES BETH H. SHAZ, MD46. TRANSFUSION OF PATIENTS UNDERGOING HPC AND SOLID ORGAN TRANSPLANTATIONJEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD47. TRANSFUSION OF HIV POSITIVE PATIENTSJEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD48. TRANSFUSION MANAGEMENT IN PATIENTS WHO REFUSE BLOOD TRANSFUSIONJEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD49. PLATELET TRANSFUSION REFRACTORY PATIENTSJEANNE E. HENDRICKSON, MD and JOHN D. ROBACK, MD, PhD50. MASSIVE TRANSFUSIONBETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 51. PERIOPERATIVE BLOOD MANAGEMENTBETH H. SHAZ, MD f. Transfusion reactions52. ADVERSE EVENTS AND OUTCOMES FOLLOWING TRANSFUSION: AN OVERVIEWCASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD53. FEBRILE NON-HEMOLYTIC TRANSFUSION REACTIONSCASSSANDRA D. JOSEPHSON, MD 54. ALLERGIC, ANAPHYLACTOID AND ANAPHYLATIC REACTIONSBETH H. SHAZ, MD 55. ACUTE HEMOLYTIC TRANSFUSION REACTIONSCASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD56. DELAYED HEMOLYTIC TRANSFUSION REACTIONSCASSSANDRA D. JOSEPHSON, MD 57. TRANSFUSION ASSOCIATED CIRCULATORY OVERLOADJEANNE E. HENDRICKSON, MD and CHRISTOPHER D. HILLYER, MD58. TRANSFUSION RELATED ACUTE LUNG INJURYJEANNE E. HENDRICKSON, MD and CHRISTOPHER D. HILLYER, MD59. SEPTIC TRANSFUSION REACTIONSCASSSANDRA D. JOSEPHSON, MD 60. METABOLIC, HYPOTENSIVE AND OTHER ACUTE REACTIONS AND COMPLICATIONSBETH H. SHAZ, MD 61. POST TRANSFUSION PURPURAALFRED J. GRINDON62. TRANSFUSION ASSOCIATED GRAFT VERSUS HOST DISEASEBETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD63. MICROCHIMERISMBETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 64. TRANSFUSION RELATED IMMUNOMODULATIONJAMES C. ZIMRING, MD, PhD65. IRON OVERLOADCASSSANDRA D. JOSEPHSON, MD 66. TRANSFUSION TRANSMITTED DISEASESBETH H. SHAZ, MDg. Therapeutic apheresis and phlebotomy67. OVERVIEW TO THERAPEUTIC APHERESISBETH H. SHAZ, MD 68. THERAPEUTIC PLASMA EXCHANGEBETH H. SHAZ, MD69. THERAPEUTIC ERYTHROCYTAPHERESISBETH H. SHAZ, MD 70. THERAPEUTIC THROMBOCYTAPHERESISBETH H. SHAZ, MD 71. THERAPEUTIC LEUKOCYTAPHERESISBETH H. SHAZ, MD 72. EXTRACORPOREAL PHOTOPHERESISMARY DORROW, MD JEANNE E. HENDRICKSON, MD, and JOHN D. ROBACK, MD, PhD 73. LDL APHERESISBETH H. SHAZ, MD74. IMMUNOABSORPTIONBETH H. SHAZ, MD 75. THERAPEUTIC PHLEBOTOMYLAWRENCE B. FIALCOW, DO and BETH H. SHAZ, MD h. Cellular therapy and tissue banking76. HPC PRODUCTSJOHN D. ROBACK, MD, PhD and ELLIE HAMILTON 77. TISSUE BANKING in the HOSPITAL SETTINGCASSSANDRA D. JOSEPHSON, MD II. CoagulationA. Introduction78. AN OVERVIEW OF THE COAGULATION SYSTEMTHOMAS C. ABSHIRE, MD and SHAWN JOBE, MD, PhDB. Clinical coagulation79. APPROACH TO THE BLEEDING PATIENTTHOMAS C. ABSHIRE, MD a. Neonatal thrombocytopenia80. CONGENITAL THROMBOCYTOPENIA SHAWN JOBE, MD, PhD 81. NEONATAL ALLOIMMUNE THROMBOCYTOPENIACAROLYN BENNETT, MD82. ACQUIRED NEONATAL THROMBOCYTOPENIACAROLYN BENNETT, MD b. inherited platelet function disorders83. BERNARD-SOULIER SYNDROME AND OTHER GPIB-IX-V RELATED RECEPTOR DEFECTSSHAWN JOBE, MD, PhD 84. GLANZMANN'S THROMBOCYTOPENIASHAWN JOBE, MD, PhD85. PLATELET STORAGE GRANULE DEFECTSSHAWN JOBE, MD, PhD86. FAILURE TO RELEASE AND ASPIRIN-LIKE DEFECTSSHAWN JOBE, MD, PhDc. Immune thrombocytopenia 87. ACUTE (CHILDHOOD) IMMUNE THROMBOCYTOPENIC PURPURA CAROLYN BENNETT, MD 88. CHRONIC IMMUNE THROMBOCYTOPENIC PURPURACAROLYN BENNETT, MD 89. DRUG INDUCED THROMBOCYTOPENIACAROLYN BENNETT, MD90. HEPARIN INDUCED THROMBOCYTOPENIACHRISTINE KEMPTON, MD91. AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROMEMICHAEL BRIONES, DOd. Immune mediated coagulopathies92. HEMOLYTIC UREMIC SYNDROMEMICHAEL BRIONES, DO 93. THROMBOTIC THROMBOCYTOPENIC PURPURACHRISTINE KEMPTON, MD94. ANTIPHOSPHOLIPID ANTIBODY SYNDROMEMICHAEL BRIONES, DO e. congenital bleeding disorders95. VON WILLEBRAND DISEASETHOMAS C. ABSHIRE, MD96. HEMOPHILIA AAMY DUNN, MD 97. HEMOPHILIA BAMY DUNN, MD 98. CONGENITAL DISORDERS OF FIBRINOGENSHANNON MEEKS, MD 99. FACTOR XIII, D á2-ANTIPLASMIN, AND PLASMINOGEN ACTIVATOR INHIBITOR-1 DEFICIENCIESSHANNON MEEKS, MD 100. FACTOR XI DEFICIENCYTHOMAS C. ABSHIRE, MD101. FACTOR VII DEFICIENCYSHANNON MEEKS, MD 102. FACTOR II, FACTOR V, AND FACTOR X DEFICIENCIESSHANNON MEEKS, MD f. acquired bleeding disorders103. BLEEDING DISORDERS IN PREGNANCYCHRISTINE KEMPTON, MD104. VASCULAR BLEEDING DISORDERSMICHAEL BRIONES, DO 105. BLEEDING RISKS WITH LIVER DISEASETHOMAS C. ABSHIRE, MD106. BLEEDING RISKS WITH VITAMIN K DEFICIENCYTHOMAS C. ABSHIRE, MD107. BLEEDING RISKS WITH CARDIAC DISEASETHOMAS C. ABSHIRE, MD108. BLEEDING RISKS WITH RENAL DISEASETHOMAS C. ABSHIRE, MD109. BLEEDING IN CANCERMICHAEL BRIONES, DO 110. DISSEMINATED INTRAVASCULAR COAGULOPATHYAMY DUNN, MD 111. ACQUIRED COAGULATION FACTOR INHIBITORSCHRISTINE KEMPTON, MDC. Laboratory testing of coagulationa. Introduction 112. INTRODUCTION TO COAGULATION TESTINGJAMES C. ZIMRING, MD, PhDb. Screening tests113. PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIMEJAMES C. ZIMRING, MD, PhD114. PLATELET COUNTJAMES C. ZIMRING, MD, PhD115. GLOBAL TESTS FOR PRIMARY HEMOSTASISCONNIE H. MILLER Ph.D.c. Laboraty assessment of platelet disorders116. PLATELET AGGREGATION STUDIESCONNIE H. MILLER Ph.D.117. LABORATORY DIAGNOSIS OF GENETIC PLATELET FUNCTION DEFECTSCONNIE H. MILLER Ph.D.118. LABORATORY DIAGNOSIS OF ACQUIRED PLATELET FUNCTION DEFECTSCONNIE H. MILLER Ph.D.119. LABORATORY DIAGNOSIS IMMUNE THROMBOCYTOPENIC PURPURACAROLYN BENNETT, MD120. ADAMTS 13 ASSAYSCHRISTINE KEMPTON, MD121. LABORATORY TESTING FOR HEPARIN INDUCED THROMBOCYTOPENIAANNE M. WINKLER, MD AND JAMES C. ZIMRING, MD, PHDd. Laboratoy assessment of VWD122. MOLECULAR BIOLOGY OF VON WILLEBRAND DISEASECONNIE H. MILLER Ph.D.123. DIAGNOSIS OF INHERITED VON WILLEBRAND DISEASEConnie H. Miller Ph.D.124. LABORATORY DIAGNOSIS OF ACQUIRED VWDCONNIE H. MILLER Ph.D.125. LABORATORY ASSESSMENT OF TREATMENT OF VWDCONNIE H. MILLER Ph.D.e. Laboratoy assessment of coagulation factor disorders126. SPECIFIC FACTOR ASSAYSCONNIE H. MILLER Ph.D.127. MIXING STUDIESCONNIE H. MILLER Ph.D.128. SPECIFIC FACTOR INHIBITORSConnie H. Miller Ph.D.f. Laboratoy assessment of fibrinogen and fibrinolysis129. LABORATORY DIAGNOSIS OF DYSFIBRINOGENEMIA AND AFIBRINOGENEMIATHOMAS C. ABSHIRE, MD130. LABORATORY ASSESSMENT OF FIBRINOLYSISTHOMAS C. ABSHIRE, MDg. Tests for hypercoagulable state131. GENERAL OVERVIEW OF THE HYPERCOAGULABLE STATEMICHAEL BRIONES, DO 132. ANTITHROMBIN TESTINGJAMES C. ZIMRING, MD, PhD133. PROTEINS C, S, AND ZJAMES C. ZIMRING, MD, PhD134. ACTIVATED PROTEIN C RESISTANCE AND FACTOR V LEIDENANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD 135. PROTHROMBIN GENE MUTATIONANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD 136. HYPERHOMOCYSTENEMIAJAMES C. ZIMRING, MD, PhD137. LUPUS ANTICOAGULANT AND ANTIPHOSPHOLIPID ANTIBODIESMICHAEL BRIONES, DO 138. LIPOPROTEIN (A)ANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD139. FACTOR LEVEL ABNORMALITIES ASSOCIATED WITH THROMBOSISJAMES C. ZIMRING, MD, PhDh. Tests for activation of the coagulation system140. LABORATORY MANAGEMENT OF DICTHOMAS C. ABSHIRE, MDi. Laboratoy support for anticoagulation141. HEPARIN MONITORINGANNE WINKLER MD AND JAMES C. ZIMRING, MD, PhD142. WARFARIN MONITORINGANNE M. WINKLER M.D.D. Coagulation factor products143. PROTHROMBIN COMPLEX CONCENTRATESCHRISTINE KEMPTON, MD144. VON WILLEBRAND FACTOR PRODUCTSTHOMAS C. ABSHIRE, MD145. FACTOR VIII CONCENTRATESAMY DUNN, MD 146. FACTOR IX CONCENTRATESAMY DUNN, MD 147. FACTOR VII CONCENTRATECHRISTINE KEMPTON, MD148. ANTITHROMBIN PRODUCTSMICHAEL BRIONES, DO 149. PROTEIN C PRODUCTSMICHAEL BRIONES, DO