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Vestibular Schwannomas

  • 1st Edition, Volume 212 - October 8, 2025
  • Latest edition
  • Editors: Simon Lloyd, Omar Pathmanaban, Gareth Evans
  • Language: English

Vestibular Schwannomas covers multiple facets of vestibular schwannomas, including advancements in surgical techniques, radiological innovations, long-term patient outcomes,… Read more

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Description

Vestibular Schwannomas covers multiple facets of vestibular schwannomas, including advancements in surgical techniques, radiological innovations, long-term patient outcomes, and implications for hearing preservation. It serves as a comprehensive guide for clinicians and researchers aiming to enhance diagnostic accuracy and therapeutic strategies in managing these complex tumors which are benign, slow-growing tumors that originate from the Schwann cells that line the vestibular nerve. They are the most prevalent neoplasms found in the cerebellopontine angle (CPA), the critical junction between the cerebellum and the brainstem.

Their incidence, clinical presentation, and impact on surrounding neurological structures make them a focal point of research and medical intervention. Understanding their etiology, diagnosis, and treatment options requires an interdisciplinary approach bridging neurology, otology, and radiology.

Key features

  • Consolidates best practices on the diagnosis and treatment of vestibular schwannomas
  • Includes both sporadic and neurofibromatosis type 2 vestibular schwannomas
  • Covers stereotaxic radiosurgery and microsurgical resection
  • Discusses molecular biology, histopathology, and genomics
  • Presents rehabilitation for neurological deficits resulting from schwannomas and treatment

Readership

Clinical Neurologists, Neurosurgeons, Otolaryngologists, Clinical Geneticists, Clinical Oncologists, Neuroradiologists, Neuropathologists, Clinical Nurse Specialists, Audiologists

Table of contents

1. History of vestibular schwannoma management

Section I. Basic Science

2. Applied anatomy in vestibular schwannoma

3. Molecular biology and disease models of vestibular schwannomas: State of the art

4. Pathology and tumor microenvironment of vestibular schwannoma

5. Genomics of vestibular schwannoma

6. Vestibular schwannomas: Key research questions and priorities

Section II. Assessment

7. Clinical evaluation and investigation of patients with a sporadic vestibular schwannoma

8. Clinical evaluation and investigation of vestibular schwannoma in NF2-related schwannomatosis

9. Vestibular schwannoma imaging and differential diagnosis

10. Clinical epidemiology of sporadic vestibular schwannomas

11. Clinical epidemiology of NF2-related schwannomatosis

Section III. Treatment

12. Surveillance management of vestibular schwannoma: present and future strategies

13. Medical therapy for vestibular schwannomas

14. Translabyrinthine approach to the cerebellopontine angle

15. Retrosigmoid approach to vestibular schwannoma

16. Middle fossa approach to vestibular schwannomas

17. The retrolabyrinthine approach

18. Endoscopic vestibular schwannoma surgery

19. Vestibular schwannoma microsurgical technique

20. Outcomes following vestibular schwannoma surgery

21. Salvage resection and radiosurgery following failed primary treatment of vestibular schwannomas

22. Hearing preservation surgery for vestibular schwannoma

23. Vestibular schwannoma, postsurgical complications

24. Anesthesia for excision of vestibular schwannoma

Section IV. Stereotactic radiosurgery for vestibular schwannomas

25. Gamma knife radiosurgery for vestibular schwannomas

26. LINAC stereotactic radiosurgery for vestibular schwannomas

27. Fractionated radiotherapy for vestibular schwannoma

28. Proton therapy for vestibular schwannomas

Section V. General Considerations

29. Decision making in sporadic VS

30. Decision making in neurofibromatosis type 2

31. Management of vestibular schwannoma in the elderly

32. Subtotal versus total excision of vestibular schwannomas

33. Quality of life after treatment of vestibular schwannomas

34. The role of the clinical nurse specialist in managing vestibular schwannoma

35. Vestibular schwannoma: Global perspectives

Section VI. Rehabilitation

36. Secondary trigeminal neuralgia due to vestibular schwannoma

37. Hearing rehabilitation in patients with vestibular schwannomas

38. Prevention and rehabilitation of facial palsy in patients with vestibular schwannomas

39. Dizziness in vestibular schwannomas

40. Tinnitus and its management in patients with vestibular schwannoma

Product details

  • Edition: 1
  • Latest edition
  • Volume: 212
  • Published: October 22, 2025
  • Language: English

About the editors

SL

Simon Lloyd

Professor Lloyd  is a  Consultant Skull Base and Auditory Implant Surgeon at the Manchester Royal Infirmary, Royal Manchester Children’s Hospital and Salford Royal Hospital. He is Professor of Otology and Skull Base Surgery at the University of Manchester and his research interests include the natural history of vestibular schwannomas and NF2-related schwannomatosis. He is widely published in his field and is frequently invited to speak both nationally and internationally. He has held a number of high profile positions including president of the British Society of Otology and secretary to the British Skull Base Society. He is president elect of the Royal Society of Medicine Otology section and is a member of the European Academy of Otology and Neuro-Otology and the Politzer Society. He has been awarded the Dalby Prize by the Royal Society of Medicine. This prize recognises the individual that has made the greatest contribution to otological research over the last 5 years. He is also the director of the UKs leading advanced otology course and skull base course. He has been deputy editor of the Mediterranean Journal of Advanced Otology and is on the editorial board of Cochlear Implants International. He has published over 100 peer reviewed papers and 17 book chapters. He has also edited two books. He regularly reviews submissions to peer reviewed medical journals including the Lancet, Otology and Neurotology, Cochlear Implants International and Clinical Otolaryngology amongst others. He is an examiner for the Intercollegiate FRCS(ORL-HNS) examinations.

Affiliations and expertise
Department of Otolaryngology, Head and Neck Surgery, Manchester Royal Infirmary, UK

OP

Omar Pathmanaban

Dr. Pathmanaban is Professor of Neurosurgery in the Division of Neuroscience at the University of Manchester and Clinical Director of the Department of Neurosurgery at the Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, UK. He is an internationally renowned skull base surgeon and is referred complex cases from across the UK and internationally. He trained in London, Manchester, Oxford, and Toronto. He was the Marjorie Newsome visiting fellow at the Barrow Neurological Institute, USA following the award of the Norman Dott Gold Medal for the most outstanding performance amongst graduating Neurosurgeons in the UK and Ireland in 2015. He is a popular invited speaker on the global skull base circuit and is on the faculty of numerous advanced microsurgery and endoscopic training courses. He has a PhD in molecular and cellular Neuro-Oncology and is group-leader of the Surgical Neuro-Oncology Manchester (SNO-Man) Laboratory, where he works as part of a team focused on translational tumor microenvironment research, including a program of work on inflammatory biomarkers and therapeutic targets in vestibular Schwannoma. He is past-secretary and current treasurer of the British Skull Base Society and has served as the Skull Base Lead for the council of the Society of British Neurological Surgeons. He sits on the Clinical Neurosciences Council of The Royal Society of Medicine and is on the panel of question writers for The Joint Committee on Intercollegiate Examinations in Neurosurgery.
Affiliations and expertise
Department of Neurosurgery, Manchester Ctr Clin Neurosci, Salford Royal Hospital, UK

GE

Gareth Evans

Professor Evans is Professor of Medical Genetics at the University of Manchester. He is one of the world’s leading experts on breast cancer genetics and Neurofibromatosis type 2. He is an NIHR Senior Investigator and has published over 760 peer reviewed research publications; 276 as first or senior author. He has published over 126 reviews and chapters and has had a book published by Oxford University Press on familial cancer. He has an ISI web of knowledge H-index of 100 and a google scholar H-index of 139 having only published his first article in 1990. In the last 5 years he has raised over £35 million in grants for multicentre and local studies – approximately £31 million to Manchester. He is Chief Investigator on two (£1.59 & £1 million) NIHR program grant (2009-2014 and 2016-2020) on breast cancer risk prediction and also has an NIHR RfPB grant as CI (2011).  He has led a successful bid for a Nationally funded NF2 service (£7.5 million pa) that started in 2010. He is theme lead and cancer lead on the All Manchester NIHR Biomedical Research Centre worth £28.5 Million (2016-2020). He also leads the NICE Familial Breast Cancer Guideline Development Group.
Affiliations and expertise
Professor of Medical Genetics, Academic Unit of Medical Genetics, St. Mary's Hospital, Manchester, UK

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