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Elsevier

Viral Proteases

  • 1st Edition, Volume 58 - November 12, 2025
  • Latest edition
  • Editors: Claudiu T. Supuran, Luigi Pisano
  • Language: English

Viral Proteases, Volume 58 in The Enzymes series, presents a comprehensive overview of recent advances in the structural and functional understanding of viral proteases and th… Read more

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Description

Viral Proteases, Volume 58 in The Enzymes series, presents a comprehensive overview of recent advances in the structural and functional understanding of viral proteases and their potential as drug targets. This new volume includes chapters covering a wide range of topics, including Viral proteases as targets for antiviral drugs, Structural biology of viral proteases, Computational approaches for designing viral protease inhibitors, The peptidomimetic approach for the design of viral protease inhibitors, HIV protease and its inhibition, and much more.

Additional sections cover Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies, Coronaviruses main proteases and their inhibitors, Coronaviruses papain-like proteases, Flaviviruses proteases (Zika, West Nile, Dengue), Bacteriophage endolysins, and Challenges for developing selective viral protease inhibitors as anti-infectives.

Key features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in The Enzymes series
  • Highlights new advances on Viral Proteases

Readership

Life science researchers, biochemists, medical scientists

Table of contents

1. Viral proteases as targets for antiviral drugs

2. Structural biology of viral proteases

3. Computational approaches for designing viral protease inhibitors

4. The peptidomimetic approach for the design of viral protease inhibitors

5. HIV protease and its inhibition

6. Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies

7. Coronaviruses main proteases and their inhibitors

8. Coronaviruses papain-like proteases

9. Flaviviruses proteases (Zika, West Nile, Dengue)

10. Bacteriophage endolysins

11. Challenges for developing selective viral protease inhibitors as anti-infectives

Product details

  • Edition: 1
  • Latest edition
  • Volume: 58
  • Published: November 12, 2025
  • Language: English

About the editors

CS

Claudiu T. Supuran

Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.
Affiliations and expertise
Full Professor, University of Florence, Neuroscience, Psychology, Medicine and Child Health, Florence, Italy

LP

Luigi Pisano

Dr. Luigi Pisano obtained his degree in Medicine and Surgery from the University of Florence in 2014, followed by a specialization in Dermatology and Venereology in 2019 from the same institution. Since November 2020, he has served as the lead physician at the Sexually Transmitted Diseases (STDs) Center within the Dermatology Unit at Piero Palagi Hospital in Florence, where he focuses on the diagnosis, treatment, and prevention of STDs in at-risk populations. He also manages a clinic dedicated to cutaneous infectious diseases, as well as a surgical and laser therapy room. Dr. Luigi Pisano coordinates a monthly multidisciplinary dermo-proctology clinic in collaboration and a bimonthly multidisciplinary dermo-gynecology clinic in partnership with a gynecologist. He has been an invited speaker at numerous national and international conferences and is the author of several scientific publications, primarily focused on the screening of HPV-related anal cancer in at-risk populations and on the emerging Mpox virus infection.

Affiliations and expertise
Health Science Department, University of Florence, Florence, Italy

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