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  • Organic Laboratory Experiments of the Future

    Doing Chemistry in Water
    • 1st Edition
    • Bruce H. Lipshutz + 1 more
    • English
    This lab manual offers students the opportunity to learn organic chemistry through a green chemistry lens, resulting in a more sustainable, future-looking course. Lipshutz and Muchalski’s Organic Laboratory Experiments of the Future: Doing Chemistry in Water approaches the subject with experiments, diagrams, and illustrations shaped by student feedback and honed through years of research and laboratory experience.Organic Laboratory Experiments of the Future: Doing Chemistry in Water includes material on reactions run in water, including but not limited to: ppm Pd-catalyzed couplings, SNAr reactions, nitro group reductions, enzyme-catalyzed reactions, catalytic hydrogenation of olefins, olefin metathesis, reductive aminations, and chemoenzymatic sequences. This lab manual is ideal for courses in organic chemistry, biochemistry, sustainable and green chemistry, and environmentally-resp... lab courses.

  • The Marmoset Brain in Stereotaxic Coordinates

    • 2nd Edition
    • George Paxinos + 3 more
    • English
    The first edition of The Marmoset Brain in Stereotaxic Coordinates (2012) was fundamental in the rapid establishment of this species as the preferred non-human primate in neuroscience research, with the atlas delineations having been adopted by all major projects using marmosets. Now, the second edition gives us the opportunity to capture 14 years of progress and introduce major enhancements:What is new in the 2nd Edition?For the first time sagittal and horizontal planes are included based on the computational average of 20 brains.For the first time cortical layers are identified.For the first time major divisions of the white matter are identified on the basis of Marmoset Brain Mapping Project (https://marmosetbra... (Liu et al., 2020).Cortical and subcortical delineations are thoroughly updated to reflect advances over the last 14 years.

  • The Handbook of Non-Invasive Transcranial Brain Stimulation in the Cognitive Domain

    Methods, Psychophysiology, Neuroenhancement and Therapeutic Applications
    • 1st Edition
    • Volume 34
    • Vincent Van Waes + 4 more
    • English
    The Handbook of Non-Invasive Transcranial Brain Stimulation in the Cognitive Domain: Methods, Psychophysiology, Neuroenhancement and Therapeutic Applications presents the latest scientific insights and technological advancements in the field of noninvasive transcranial brain stimulation (NIBS) within the cognitive domain. This comprehensive volume reviews published research and explores future directions for the use of NIBS techniques, in particular repetitive transcranial magnetic stimulation (rTMS) and low-intensity transcranial electrical stimulation (tDCS, tACS), to study and modulate human cognition as well as to treat various psychiatric and neurological disorders from a neurocognitive perspective. By integrating findings from preclinical animal studies, modeling approaches, and research, this book sheds light on the neurobiological mechanisms underlying cognitive processes and neuroplasticity. It provides a detailed analysis of how NIBS affects psychophysiology and cognitive performance in healthy populations while offering insights into its therapeutic potential for patients with cognitive impairments across a wide range of neuropsychiatric disorders.This handbook offers an unparalleled gateway to the dynamic and rapidly advancing field of neuromodulation and serves as an essential resource for researchers, clinicians, students, and policymakers.

  • Reconstructive Transplantation and Regenerative Surgery

    The New Frontier
    • 1st Edition
    • Volume 3
    • Vijay Gorantla + 2 more
    • English
    Reconstructive Transplantation and Regenerative Surgery: The New Frontier is the third volume in the Regenerative and Transplant Medicine Series. This volume captures a decade of transformative progress at the intersection of reconstructive transplantation, regenerative medicine, and tissue engineering—fields that have begun to converge into a bold new frontier: regenerative surgery. Coedited by internationally recognized leaders in the field, this authoritative work explores cutting-edge advances that are redefining the possibilities for patients with complex tissue loss and functional deficits.Through comprehensive and original chapters written by global experts, this book charts the latest innovations in vascularized composite allotransplantation (VCA), graft immunomodulation, neurogeneration and diagnostics, ischemia mitigation and tissue preservation, and tissue engineering and biomaterials.Compreh... in scope and visionary in approach, Reconstructive Transplantation and Regenerative Surgery: The New Frontier is an essential resource for surgeons, researchers, biomedical engineers, and clinicians.

  • Genetic Testing in Breast Cancer

    Innovations in Diagnosis and Treatment
    • 1st Edition
    • Manzoor Ahmad Mir
    • English
    Genetic Testing in Breast Cancer: Innovations in Diagnosis and Treatment addresses the urgent need for novel, minimally invasive diagnostic techniques to accurately identify breast cancer early and monitor treatment efficacy, focusing particularly on triple-negative breast cancer (TNBC). This comprehensive volume analyzes the latest research and developments in genetic testing, covering strategies like next-generation sequencing and the Sanger method. It highlights their potential to revolutionize early diagnosis and personalized treatment plans. The book also discusses challenges and opportunities, providing insights into hereditary mutations, genetic counseling, and clinical practice integration.Serving as a valuable resource for students, researchers, oncologists, pharmacologists, and healthcare professionals, it includes preclinical and clinical case studies that illustrate the practical applications of genetic testing for various breast cancer subtypes, including TNBC and HER2-positive breast cancer. The editors aim to advance treatment and improve patient outcomes through cutting-edge genetic testing techniques.

  • Endotoxin in Critical Illness

    • 1st Edition
    • John Kellum + 1 more
    • English
    Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.

  • Fundamentals and Therapeutic Applications of Liposomes

    • 1st Edition
    • Prashant Kesharwani
    • English
    Fundamentals and Therapeutic Applications of Liposomes provides an in-depth exploration of liposomal delivery systems for therapeutic purposes. This comprehensive book covers the synthesis and scaling up of liposomes for clinical use, examining their diverse applications in cancer therapy, immunotherapy, gene delivery, wound healing, viral disease, and neurological disorders. It also summarizes the regulatory aspects associated with clinical translation and industrial production. The book addresses the toxicity, safety, and environmental considerations of using liposomes for therapeutics, making it a useful resource for researchers, academics, and R&D groups interested in the development, production, and application of liposomes in various therapeutic settings.

  • Harnessing Endogenous Mechanisms for Targeted Drug Delivery

    • 1st Edition
    • Anisha A. D’Souza + 2 more
    • English
    Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.

  • Stem Cells and Tissue Regeneration

    Bridging Research and Clinical Practice
    • 1st Edition
    • Wen Zeng + 2 more
    • English
    Stem Cells and Tissue Regeneration: Bridging Research and Clinical Practice delves into the latest advancements in the dynamic field of tissue regeneration. This comprehensive book begins with an introduction that reviews stem cell classifications, characteristics, functions, and their integral relationship with tissue regeneration. This first section offers readers a solid foundation and understanding of the book’s scope and significance in contemporary research and clinical applications. Subsequent chapters explore each major organ, including skeletal muscle regeneration and vascular organoids.Additional... the book presents innovative strategies and methods for research, culminating in a forward-looking perspective on the future of tissue regeneration. Authored by experts, it serves as a vital resource for researchers, clinicians, and surgeons involved in tissue repair.

  • Drug Metabolism in Diseases

    Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development
    • 2nd Edition
    • Wen Xie
    • English
    Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, Second Edition provides essential knowledge for pharmaceutical scientists and biologists to understand the interplay between diseases and physiological conditions, impacting drug metabolism and its implications in personalized treatment. Expanded with six new chapters since the first edition, this updated book covers the latest scientific findings. Other important points include the book’s comprehensive reference on mutual effects between drug metabolism and diseases, implications in precision medicine, and therapeutic development. Pharmaceutical scientists, drug metabolism researchers, and research physicians will benefit from the expert insights provided.

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