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Elsevier

Academic Press

  • Epigenetics and DNA Damage

    • 1st Edition
    • Volume 33
    • Miriam Galvonas Jasiulionis
    • English
    Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.

  • Environmental Data Analysis with MatLab or Python

    Principles, Applications, and Prospects
    • 3rd Edition
    • William Menke
    • English
    Environmental Data Analysis with MATLAB, Third Edition, is a new edition that expands fundamentally on the original with an expanded tutorial approach, more clear organization, new crib sheets, and problem sets providing a clear learning path for students and researchers working to analyze real data sets in the environmental sciences. The work teaches the basics of the underlying theory of data analysis and then reinforces that knowledge with carefully chosen, realistic scenarios, including case studies in each chapter. The new edition is expanded to include applications to Python, an open source software environment. Significant content in Environmental Data Analysis with MATLAB, Third Edition is devoted to teaching how the programs can be effectively used in an environmental data analysis setting. This new edition offers chapters that can both be used as self-contained resources or as a step-by-step guide for students, and is supplemented with data and scripts to demonstrate relevant use cases.

  • A Pharmacology Primer

    Techniques for More Effective and Strategic Drug Discovery
    • 6th Edition
    • Terry P. Kenakin
    • English
    A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.

  • Technologies to Recover Polyphenols from AgroFood By-products and Wastes

    • 1st Edition
    • Elisabete M.C. Alexandre + 2 more
    • English
    Technologies to Recover Polyphenols from AgroFood By-products and Wastes: Applications in Different Fields covers the most used technologies to extract and recover polyphenols from all kinds of by-products and wastes generated by the food industry, restaurant and agricultural sectors. Polyphenols are characterized by different AgroFood by-products and waste sources, hence this book explores the practical applications of these polyphenols in the development of functional foods and pharmaceutical and cosmetic products. Containing definitions, case studies, applications, literature reviews, and coverage of recent developments, this book will be a welcomed resource for food scientists, including those working in sustainability, agriculture and engineering.

  • Metals and Metalloids in Soil-Plant-Water Systems

    Phytophysiology and Remediation Techniques
    • 1st Edition
    • Tariq Aftab + 1 more
    • English
    Metals and Metalloids in Soil-Plant-Water Systems: Phytophysiology and Remediation Techniques examines the impact of metal/metalloid contamination on the plant lifecycle, along with microbes present in soil. Highlighting uptake and translocation, the book also examines antioxidant, photosynthesis and growth characteristics of plants grown in metal contaminated soil. Beginning with an introduction to different sources of soil and water pollution, chapters assess the environmental cytotoxicity pollution impact on plants, as well as how the generation of reactive oxygen and nitrogen species in plant tissues is affected. The book also discusses various soil remediation methodologies, including the potential applications of metal oxidizing microbes and nanomaterials. This is an essential resource for researchers and students interested in plant physiology, soil science, environmental science and agriculture.

  • Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI Approach

    • 1st Edition
    • Anirudh Nath + 2 more
    • English
    Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI-Based Approach exposes readers to the various existing mathematical models that define the dynamics of glucose-insulin for Type 1 diabetes patients. After providing insights into the mathematical model of patients, the authors discuss the need and emergence of new control techniques that can lead to further development of an artificial pancreas. The book presents various nonlinear control techniques to address the challenges that Type 1 diabetic patients face in maintaining their blood glucose level in the safe range (70-180 mg/dl). The closed-loop solution provided by the artificial pancreas depends mainly on the effectiveness of the control algorithm, which acts as the brain of the system. APS control algorithms require a mathematical model of the gluco-regulatory system of the T1D patients for their design. Since the gluco-regulatory system is inherently nonlinear and largely affected by external disturbances and parametric uncertainty, developing an accurate model is very difficult.

  • Solar Receivers for Thermal Power Generation

    Fundamentals and Advanced Concepts
    • 1st Edition
    • Amos Madhlopa
    • English
    Solar Receivers for Thermal Power Generation: Fundamentals and Advanced Concepts looks at different Concentrated Solar Power (CSP) systems, their varying components, and the modeling and optimization of solar receivers. The book combines the detailed theory of receivers, all physical concepts in the process of converting solar radiation into electricity in CSP systems, and the main components of CSP systems, including solar concentrators, thermal receivers and power blocks. Main properties and working principles are addressed, along with the principles of solar resources and energy output of CSP systems and solar radiation. By covering different types and designs of solar receivers, heat transfer fluids, operating temperatures, and different techniques used in modeling and optimizing solar receivers, this book is targeted at academics engaged in sustainable energy engineering research and students specializing in power plant solarization.

  • Hazardous and Trace Materials in Soil and Plants

    Sources, Effects, and Management
    • 1st Edition
    • M. Naeem + 4 more
    • English
    Hazardous and Trace Materials in Soil and Plants: Sources, Effects and Management explores the latest advancements in reducing, avoiding and eliminating soil contaminants that challenge the health and safety of agricultural plants. With a focus on minimizing the production of those hazardous substances, controlling their distribution and ensuring safe utilization, the book explores each contributing area and provides insights toward improved, sustainable and secure production. This is an excellent reference resource on both current research and future directions from laboratory research to field applications. The combined impacts of climate change and industrialization have led to increased and diversified threats to the health of the soil in which our food crops are grown, as well as in the plants themselves. This dual-hazard scenario is increasingly recognized as a threat to not just the environment, but to global food security as agricultural soils contaminated with pollutants alter plant metabolism, thus resulting in reduced crop quality and production quantity.

  • Helicase Enzymes Part B

    • 1st Edition
    • English
    Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Post-transcriptional Gene Regulation in Human Disease

    • 1st Edition
    • Volume 32
    • Buddhi Prakash Jain + 2 more
    • English
    Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.

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