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Elsevier

Elsevier

  • Validamycin and Its Derivatives

    Discovery, Chemical Synthesis, and Biological Activity
    • 1st Edition
    • Xiaolong Chen + 3 more
    • English
    Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.

  • Dehydroacetic Acid and Its Derivatives

    Useful Synthons in Organic Synthesis
    • 1st Edition
    • Santhosh Penta
    • English
    Dehydroacetic Acid and Its Derivatives: Useful Synthons in Organic Synthesis outlines the use of DHA and its derivatives for the synthesis of pharmacologically active heterocyclic compounds. Beginning with an introduction to the chemistry and reactivity of Dehydroacetic Acid, the book goes on to outline the key ring transformation reactions of DHA. The synthesis of various derivatives is then discussed, before a wide range of metal complexes of DHA are explored in detail. The book then concludes with a review of DHA’s biological importance and its impressive range of pharmacological activities, including anti-cancer, anti-bacterial, anti-fungal and analgesic properties. For those researching the synthesis of bioactive heterocyclic compounds, this book is a valuable guide on the fundamental knowledge needed to facilitate and enhance the successful synthesis of lead molecules.

  • Clinical Naturopathy: In Practice

    • 1st Edition
    • Jerome Sarris + 1 more
    • English
    Clinical Naturopathy: In Practice applies the research, principles and treatment protocols outlined in Clinical Naturopathy: An Evidence-Based Guide to Practice, 2nd Edition. Written by a team of world-leading naturopathic practitioners and academics, Clinical Naturopathy: In Practice demonstrates the clinical decision-making processes in treating common conditions. It shares the clinical experiences of the expert authors, provides a gold-standard, integrative approach to real-world cases, and will guide you to deliver better clinical outcomes for your patients.

  • Infection, An Issue of Orthopedic Clinics

    • 1st Edition
    • Volume 48-2
    • James H. Calandruccio + 5 more
    • English
    This issue of Orthopaedic Clinics will focus on infection. This issue will include articles on: Charcot Arthropathy versus Osteomyelitis: Evaluation and Management; Physical function, and physical activity in obese adults after total knee arthroplasty; DVT and PE Considerations in Orthopaedic Surgery; The Impact of Negative Pressure Wound Therapy on Orthopaedic Infection; Role of Systemic and Local Antibiotics in the Treatment of Open Fractures; Acute Hematogenous Osteomyelitis in Children; and many more!

  • T-Cell Lymphoma, An Issue of Hematology/Oncology Clinics of North America

    • 1st Edition
    • Volume 31-2
    • Eric D. Jacobsen
    • English
    This issue of Hematology/Oncology Clinics will feature articles such as: Anaplastic large cell lymphomaj; New agents; Transplant, Uncommon variants; ATLL, CD30+ LPD of skin; NK/T, MF/SS; and many more!

  • Reproductive Medicine, An Issue of Veterinary Clinics of North America: Exotic Animal Practice

    • 1st Edition
    • Volume 20-2
    • Vladimir Jekl
    • English
    This issue of Veterinary Clinics of North America: Exotic Animal Practice, Edited by Dr. Vladimir Jekl, focuses on Reproductive Medicine. Topics include: Reproductive disorders in aquarium fish; Reproductive disorders in amphibians; Imaging methods in the diagnostics of reproductive tract disorders in reptiles; Management of reproductive disorders in sea turtles; Reproductive medicine in fresh water turtles and tortoises; Diseases of the reproductive tract in snakes; Perinatology in reptiles; Reproductive medicine in lizards; Reproductive medicine in birds of prey; Reproductive disorders in parrots; Reproductive disorders in commonly kept fowl; Reproductive medicine in rabbits; Reproductive medicine in guinea pigs, chinchillas and degus; Reproductive disorders in marsupials; Reproductive medicine in ferrets; Reproductive disorders of rescue animals.

  • Functional Rhinoplasty, An Issue of Facial Plastic Surgery Clinics of North America

    • 1st Edition
    • Volume 25-2
    • Benjamin C. Marcus
    • English
    This issue of Facial Plastic Surgery Clinics, guest edited by Dr. Benjamin C. Marcus, is devoted to Functional Rhinoplasty. Articles in this outstanding issue include: Essential Anatomy and Evaluation for Functional Rhinoplasty; Septoplasty: Basic and Advanced Techniques; The Role of the Inferior Turbinate in Rhinoplasty; The External Nasal Valve; The Internal Valve: Dynamic and Static Repairs; The Art of Osteotomies; Repair of Nasal Septum Perforations; Management of Pediatric Rhinoplasty; Cleft Septorhinoplasty: Form and Function; The Saddle Deformity: Camouflage and Reconstruction; Revision Functional Surgery: Salvaging Function; and Advances in Technology for Functional Rhinoplasty.

  • Microsurgery: Global Perspectives, An Issue of Clinics in Plastic Surgery

    • 1st Edition
    • Volume 44-2
    • Jin Bo Tang + 1 more
    • English
    This issue of Clinics in Plastic Surgery, guest edited by Drs. Jin Bo Tang and Michel Saint-Cyr, is devoted to Microsurgery: Global Perspectives. Articles in this issue include: Digital Replantation: Current Status in the World; Exploring New Frontiers of Microsurgery: From Anatomy to Clinical Methods; Free Flaps, Toe Transfers and Microsurgery for Crush Injury in the Hand; Vascularised Bone Grafting for Scaphoid and Lunate Diseases; Vascularised Small Bone Grafting to Treat Scaphoid Non-Union: Outcomes; Compound or Specially Designed Flaps and Other Tissue Transfers in Upper and Lower Extremities; Special Considerations in Upper and Lower Extremity Pediatric Microsurgical Reconstruction; Microsurgical Tissue Transfer in Breast Reconstruction; Non-abdominal Based Free and Pedicle Flaps in Autologous Breast Reconstruction; Complex Microsurgical Reconstruction after Tumor Resection in the Trunk and Extremities; Keystone and Pedicle Perforator flaps in Sarcoma Reconstruction: New Modifications and Applications; Innovations and Future Directions in Head and Neck Microsurgical Reconstruction; New Frontiers in Robotic Assisted Microsurgical Reconstruction; and Current Methods to Deal with Vascular Crisis After Microsurgery: A Global View.

  • Progress in Optics

    • 1st Edition
    • Volume 62
    • English
    Progress in Optics, Volume 62, an ongoing series, contains more than 300 review articles by distinguished research workers that have become permanent records for many important developments. In this updated volume, users will find valuable updates on topics such as optical testing, the modern aspects of intensity interferometry with classical light, the generation of partially coherent beams, optical models and symmetries, and more. This book's contributions have become standard references in scientific articles, providing the state-of-the-art to researchers and practitioners who work in the field of optics.

  • Nano- and Microscale Drug Delivery Systems

    Design and Fabrication
    • 1st Edition
    • Alexandru Mihai Grumezescu
    • English
    Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems. Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. This book is designed to offer a cogent, concise overview of current scholarship in this important area of research through its focus on the characterization and fabrication of a variety of nanomaterials for drug delivery applications. It is an invaluable reference source for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems.

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