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Elsevier

Pergamon

  • Cellular and Molecular Toxicology

    Volume 14
    • 1st Edition
    • J.P. Vanden Heuvel + 3 more
    • English
    Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately.Toxicolog... is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response.Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation.A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

  • Nuclear Magnetic Resonance

    Petrophysical and Logging Applications
    • 1st Edition
    • Volume 32
    • K.-J. Dunn + 2 more
    • English
    The applications of nuclear magnetic resonance (NMR) to petroleum exploration and production have become more and more important in recent years. The development of the NMR logging technology and the NMR applications to core analysis and formation evaluation have been very rapid and extensive.The scope of this book covers a wide range of NMR related petrophysical measurements on cores including brief descriptions of recent applications of Magic Angle Spinning (MAS) NMR and the basics of NMR imaging of cores. In the discussion of NMR logging applications various schemes of using NMR logs to obtain necessary information for formation evaluation are outlined, such as irreducible water saturation determination, hydrocarbon typing, oil viscosity estimation, and permeability prediction. The principles of these applications are discussed using schematic diagrams for illustration.A unique aspect of the book is that it provides a detailed account of the basic principles of spin diffusion and relaxation in porous media. Another important area that is covered is the inversion of NMR data into a distribution of amplitudes associated with relaxation time which provides the basic information needed to interpret the NMR measurements obtained from logging.

  • Concise Encyclopedia of Sociolinguistics

    • 1st Edition
    • R. Mesthrie
    • English
    This is the ninth in the acclaimed series of spinoff volumes based on the outstanding Encyclopedia of Language and Linguistics. It comprises 285 articles of which 80 are short biographical entries. 50 of the biographies and 42 other articles are entirely new, while the remaining entries are suitably revised and updated from ELL. This work provides uniquely comprehensive and authoritative information on all aspects of sociolinguistics.

  • Biology at the Single Molecule Level

    • 1st Edition
    • S.H. Leuba + 1 more
    • English
    This is the first book solely devoted to single-molecule biochemistry and molecular biology. Authors were selected on the basis of their contribution to this new and exciting field, and were asked to focus more on the biological problems that can be approached using single-molecule techniques rather than on the techniques per se. It is thought that such techniques will eventually dominate the physical characterization of biologically important macromolecules.

  • Handbook of Conceptualization and Treatment of Child Psychopathology

    • 1st Edition
    • Helen Orvaschel + 2 more
    • English
    Handbook of Conceptualization and Treatment of Child Psychopathology evaluates and illustrates the integration of conceptualization and treatment of child and adolescent psychopathology. Organized into seven parts, this book first discusses the issues of conceptualization and developmental considerations in treatment. Subsequent part delineates treatment models and specific interventions for disruptive behavior disorders. Parts III-VI elucidate mood, anxiety, eating and substance use disorders. The last part covers firesetting, trichotillomania, elimination disorders, schizophrenia, sleep problems, and dissociative disorders. This handbook is an educational tool for graduate students and a resource for psychologists, psychiatrists, school counselors, social workers, and other mental health practitioners who treat children and adolescents and their families.

  • Alkaloids: Chemical and Biological Perspectives

    • 1st Edition
    • Volume 15
    • S.W. Pelletier
    • English
    Alkaloids: Chemical and Biological Perspectives, the 15th volume of the ACBP series, features four important reviews of research on alkaloids. Chapter 1 is the first comprehensive review of the carbon-13 and proton NMR shift assignments and physical constants of diterpene alkaloids and their derivatives. In addition to the catalogue of spectral and physical data, the chapter includes a table of the occurrences of these alkaloids in various plant species, tables containing molecular formulas versus calculated high-resolution mass values, and calculated high-resolution mass values versus the molecular formulas of diterpenoid alkaloids, as well as seven tables summarizing the carbon-13 chemical shifts of various functional groups in diterpenoid alkaloids. Chapter 2 is a fascinating review of the supercritical fluid extraction of alkaloids. This technique using basic modifiers, provides an alternative method for the extraction of alkaloids.Chapter 3 summarizes recent advances in the synthesis of Amaryllidaceae alkaloids, an important class of naturally-occurring bases and neutral compounds. The increased activity in the synthesis of these alkaloids over the last decade is undoubtedly due to the fact that certain members of this family possess interesting and useful biological properties. Elegant syntheses, chiral and otherwise, of structures incorporating many asymmetric centres are reviewed.Chapter 4 reviews radical cyclization reactions in the total synthesis of indole alkaloids. The use of free radical chemistry in the synthesis of alkaloids has grown markedly because of the mild reaction conditions, tolerance of a wide variety of functional groups, and the good stereoselectivities.... chapter in this volume has been reviewed by at least one specialist in the field.

  • RNA

    • 1st Edition
    • D. Söll + 2 more
    • English
    This publication summarizes the current status of our understanding of RNA, with particular emphasis on the chemistry of this key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA and RNA enzymes (ribozymes). The different chapters detail biophysical and chemical methods to investigate RNA structure and function, the synthesis of native and modified RNAs and the latest advances in our understanding of the vast array of biological processes in which RNA is involved.

  • International Encyclopedia of Social & Behavioral Sciences

    • 1st Edition
    • N. J. Smelser + 1 more
    • English
    This Encyclopedia is the first attempt in a generation to map the social and behavioral sciences on a grand scale. Not since the publication in 1968 of the International Encyclopedia of the Social Sciences, edited by David L. Sills, has there been such an ambitious project to describe the state of the art in all the fields encompassed within the social and behavioral sciences. Available in both print (26 volumes) and online editions, it comprises 4,000 articles, commissioned by 52 Section Editors, and includes 90,000 bibliographic references as well as comprehensive name and subject indexes.

  • Artificial Intelligence in Agriculture 2001

    • 1st Edition
    • I. Farkas
    • English
    This Proceedings contains the papers presented at the AIA'2001 Workshop on "Artificial Intelligence in Agriculture", held at the Hotel Eben in Budapest and the Campus of the Szent István University Gödöllo, Hungary, on 6-8 June 2001.The papers demonstrate the aim of the workshop, which was to bring together leading researchers and practitioners from academy and industry in order to favour the emergence or consolidation of bridges between AI and its applications in Agriculture and domains connected to it (in particular, environmental sciences).This Proceedings concentrate on five main topic areas: Fundamentals, Decision tools; Neural networks; Quality and measurements; Fuzzy modelling and control and Modelling and control.

  • Progress in Heterocyclic Chemistry

    A Critical Review of the 2000 Literature Preceded by Two Chapters on Current Heterocyclic Topics
    • 1st Edition
    • Volume 13
    • G.W. Gribble + 1 more
    • English
    This volume of Progress in Heterocyclic Chemistry(PHC) is the thirteenth annual review of the literature, covering the work published on important heterocyclic ring systems during 2000. In this volume there are two specialized reviews. The first, by H. Ila, H. Junjappa and P.K. Mohanta, covers their work on annulation using ∝-oxoketene dithioacetals, a synthetic method that provides useful routes to an impressively wide range of fused heterocycles. The second, by R. N. Warrener, is on the synthesis of fused 7-azanorbornanes. The 7-azanorbornane structural unit is incorporated into a series of elegant polycyclic molecules with rigid geometry. The subsequent chapters, arranged by increasing heterocycle ring size, review recent advances in the field of heterocyclic chemistry with emphasis on synthesis and reactions.

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