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Pergamon

Comprehensive Supramolecular Chemistry
1st Edition
Jerry L. Atwood + 1 more
English
Comprehensive Supramolecular Chemistry covers for the first time in eleven detailed volumes the exciting inter- and multidisciplinary area of modern supramolecular chemistry. This subject, which has now reached an astonishing diversity and complexity, has developed at a remarkably rapid pace following the initial discoveries of crown ethers and cryptands in the late sixties.The numerous references, including many recent citations, constitute an unrivalled in-depth source for direct entry to the widespread primary literature on any aspect of this most highly topical area. The many carefully selected illustrations and instructive schematic representations make the chapters easily readable.
Development and Validation of Analytical Methods
1st Edition
Volume 3
Christopher M. Riley + 1 more
English
The need to validate an analytical or bioanalytical method is encountered by analysts in the pharmaceutical industry on an almost daily basis, because adequately validated methods are a necessity for approvable regulatory filings. What constitutes a validated method, however, is subject to analyst interpretation because there is no universally accepted industry practice for assay validation. This book is intended to serve as a guide to the analyst in terms of the issues and parameters that must be considered in the development and validation of analytical methods. In addition to the critical issues surrounding method validation, this book also deals with other related factors such as method development, data acquisition, automation, cleaning validation and regulatory considerations. The book is divided into three parts. Part One, comprising two chapters, looks at some of the basic concepts of method validation. Chapter 1 discusses the general concept of validation and its role in the process of transferring methods from laboratory to laboratory. Chapter 2 looks at some of the critical parameters included in a validation program and the various statistical treatments given to these parameters.Part Two (Chapters 3, 4 and 5) of the book focuses on the regulatory perspective of analytical validation. Chapter 3 discusses in some detail how validation is treated by various regulatory agencies around the world, including the United States, Canada, the European Community, Australia and Japan. This chapter also discusses the International Conference on Harmonization (ICH) treatment of assay validation. Chapters 4 and 5 cover the issues and various perspectives of the recent United States vs. Barr Laboratories Inc. case involving the retesting of samples. Part Three (Chapters 6 - 12) covers the development and validation of various analytical components of the pharmaceutical product development process. This part of the book contains specific chapters dedicated to bulk drug substances and finished products, dissolution studies, robotics and automated workstations, biotechnology products, biological samples, analytical methods for cleaning procedures and computer systems and computer-aided validation. Each chapter goes into some detail describing the critical development and related validation considerations for each topic.This book is not intended to be a practical description of the analytical validation process, but more of a guide to the critical parameters and considerations that must be attended to in a pharmaceutical development program. Despite the existence of numerous guidelines including the recent attempts by the ICH to be implemented in 1998, the practical part of assay validation will always remain, to a certain extent, a matter of the personal preference of the analyst or company. Nevertheless, this book brings together the perspectives of several experts having extensive experience in different capacities in the pharmaceutical industry in an attempt to bring some consistency to analytical method development and validation.
Connections in Steel Structures III
Behaviour, Strength and Design
1st Edition
Reidar Bjorhovde + 2 more
English
This book publishes the proceedings from the Third International Workshop on Connections in Steel Structures: Behaviour, Strength and Design held in Trento, Italy, 29-31 May 1995. The workshop brought together the world's foremost experts in steel connections research, development, fabrication and design. The scope of the papers reflects state-of-the-art issues in all areas of endeavour, and manages to bring together the needs of researchers as well as designers and fabricators. Topics of particular importance include connections for composite (steel-concrete) structures, evaluation methods and reliability issues for semi-rigid connections and frames, and the impact of extreme loading events such as those imposed by major earthquakes. The book highlights novel methods and applications in the field and ensures that designers and other members of the construction industry gain access to the new results and procedures.
Fatigue '96
1st Edition
G. Lütjering + 1 more
English
The aim of the 6th International Fatigue Congress, besides covering the entire field of fatigue, was to promote the intimate connection between basic science and engineering application by the selection of appropriate session topics.Fatigue is the main cause of failure of engineering structures and components. Making reliable fatigue predictions is highly difficult because knowledge about fatigue mechanisms in all stages of the fatigue process must be developed much further. In addition, the decreasing availability of raw materials and energy resources forces engineers to continually reduce the weight of constructions. This congress presents research results also particularly for new materials, including composites. Researchers, on the other hand, are confronted with the engineering demands. Futhermore, the overwhelming development which is presently taking place in the field of computer software and hardware dealing with fatigue problems is outlined along with the directions of future developments in all areas of fatigue.Close to 300 fully peer-reviewed papers are published in the proceedings, including nearly 30 overview and keynote papers covering the various session topics. The proceedings should therefore serve as a comprehensive review of the fatigue field at the present state-of-the-art, suitable for scientists, engineers and students.
Alkaloids: Chemical and Biological Perspectives
1st Edition
Volume 10
S.W. Pelletier
English
Volume 10 of this series presents four timely reviews. Chapter 1 provides a fascinating account of the history of alkaloid discovery in Australia beginning with the isolation of the first alkaloid from an Australian plant, the Tasmanian sassafras (Atherosperma moschatum), by Zeyer in 1861. Also included is a comprehensive survey of alkaloid-bearing plants, and a section dealing with detection, estimation, extraction, and work-up procedures for alkaloids.Chapter 2 provides a comprehensive update to the chapter on "Pyridine and Piperidine Alkaloids" which appeared in volume 3 of this series. The focus of this chapter is on new alkaloids isolated, biosynthesis, and biological properties.Chapter 3 looks at "3-Alkylpiperidine Alkaloids Isolated from Marine Sponges in the Order Haplosclerida". Studies over the past thirty years have shown that sponges are a rich source of alkaloids. Many of these sponge alkaloids are related to each other by the presence of a 3-alkylpiperidine moiety in their structures and it happens that the sponges that have been reported to contain 3-alkylpiperidine alkaloids are all in the order Haplosclerida.Chapte... 4 reviews &bgr;-carboline and isoquinoline alkaloids which are pharmacologically some of the most significant marine natural products. This chapter treats the isolation, structure elucidation, synthesis, biosynthesis, and pharmacological activity of these alkaloids.
Accounting for Improvement
1st Edition
Sten Jonsson
English
Accounting for Improvement offers concrete and constructive demonstrations of the possibilities of designing participative forms of organization. Field experiment cases illustrate how the operational level can assume a new significance in competitiveness and strategic positioning. In this way, the relevance of the accounting function to the improvement of productivity and quality is restored.Several broadly applicable lessons can be learnt, among them: how companies can strengthen their competitive base by patient improvement; how people with operative jobs can take command of their work situation and improve it in quality as well as efficiency.New bottom-up, people-orientated, empirically-founded approaches to decentralised participative management demonstrate a place for individuals and teamwork in today's "lost relevance" and "smart machine" environment.
Thin-Walled Structures with Structural Imperfections
1st Edition
L.A. Godoy
English
Thin-walled structures are designed with advanced numerical analysis techniques and constructed using sophisticated fabrication processes. There are, however, a number of factors that may result in a structure that is not exactly coincident with what was considered during the design calculations. These features may be associated with changes in the properties of the structure, in the geometry, and many others. But even small changes in the structure may sometimes produce significant changes in the response.The present work is intended to introduce professionals and researchers to the effects of imperfections on the stresses in thin-walled structures. The main idea behind the presentation is that small imperfections may introduce changes in the stresses that are nearly equal to the stresses due to the loads.The book is organized into two main parts. The first part (Chapters 1 to 6) covers the techniques for analyzing imperfections. In the second part the emphasis is on applications, which at present may be found scattered throughout many scientific and professional journals. More practical aspects of imperfections may be found in Chapter 12.It is assumed that the reader is familiar with finite element techniques, and with the basics of shell structures.
Metal Surface Electron Physics
1st Edition
A. Kiejna + 1 more
English
During the last thirty years metal surface physics, or generally surface science, has come a long way due to the development of vacuum technology and the new surface sensitive probes on the experimental side and new methods and powerful computational techniques on the theoretical side. The aim of this book is to introduce the reader to the essential theoretical aspects of the atomic and electronic structure of metal surfaces and interfaces. The book gives some theoretical background to students of experimental and theoretical physics to allow further exploration into research in metal surface physics.The book consists of three parts. The first part is devoted to classical description of geometry and structure of metal crystals and their surfaces and surface thermodynamics including properties of small metallic particles. Part two deals with quantum-mechanical description of electronic properties of simple metals. It starts from the free electron gas description and introduces the many body effects in the framework of the density functional theory, in order to discuss the basic surface electronic properties of simple metals. This part outlines also properties of alloy surfaces, the quantum size effect and small metal clusters. Part three gives a succinct description of metal surfaces in contact with foreign atoms and surfaces. It treats the work function changes due to alkali metal adsorption on metals, adhesion between metals and discusses the universal aspects of the binding energy curves. In each case extensive reference lists are provided.
An Accounting Thesaurus
500 years of accounting
1st Edition
Richard L. Chambers
English
A compilation drawn from over 500 years of English language accounting literature reflecting a lifetime of scholarly enquiry, this book comprises over 5000 quotations of between 1-20 lines in length. The book aims to give an historical perspective as well as an up-to-date overview of what accounting and accountants were, are and do, and is intended both as a reference book and a research tool. Its range extends from general interest to the advanced, covering rules, practices and standards, professional and academic opinions, and the social and logical foundations of accounting; it also draws on the work of scholars in other fields that have some bearing on accounting work and thought.
Analysis, Design and Evaluation of Man-Machine Systems 1995
1st Edition
T.B. Sheridan
English
The series of IFAC Symposia on Analysis, Design and Evaluation of Man-Machine Systems provides the ideal forum for leading researchers and practitioners who work in the field to discuss and evaluate the latest research and developments. This publication contains the papers presented at the 6th IFAC Symposium in the series which was held in Cambridge, Massachusetts, USA.

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