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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Experimental Design

    A Handbook and Dictionary for Medical and Behavioral Research
    • 1st Edition
    • Volume 14
    • J. Krauth
    • English
    Scientists planning experiments in medical and behavioral research will find this handbook and dictionary an invaluable desk reference tool. Also recommended as a textbook for students of Experimental Design or accompanying courses in Statistics. Principles of experimental design are introduced, techniques of experimental design are described, and advantages and disadvantages of often used designs are discussed.This two-part volume, a handbook of experimental design and a dictionary providing short explanations for many terms related to experimental design, contains information that will not quickly become outdated.

  • Brain Plasticity and Epilepsy: A Tribute to Frank Morrell

    • 1st Edition
    • Volume 45
    • English
    This volume of International Review of Neurobiology integrates the latest developments in normal and abnormal neuroplasticity and epilepsy, and considers their implications for understanding the basic mechanisms of normal and pathological behaviors. The chapters are written by leaders in the field, and provide comprehensive coverage of the subject, from molecular neurobiology to behavior. This book will help neuroscientists gain a better understanding of the application of fundamental neuronal mechanisms of plastic change to problems relevant to the diagnosis, treatment, and prevention of human disease, particularly epilepsy.

  • Exploring the Thalamus

    • 1st Edition
    • S. Murray Sherman + 1 more
    • English
    The thalamus is a group of cells placed centrally in the brain that serve a critical role in controlling how both sensory and motor signals are passed from one part of the cerebral cortex to another. Essentially, all information reaching the cerebral cortex and thus consciousness is relayed through the thalamus. The role of the thalamus in controlling the flow of information (such as visual, auditory, and motor) to the cortex has only recently begun to be understood. This book provides an in-depth look at the function of the thalamus and its role as relayer of information to the cerebral cortex. The authors explore how the thalamus controls messages that are passed to the cortex and they introduce the novel suggestion that the thalamus serves a critical role in controlling how messages pass from one part of the cortex to another. Exploring the Thalamus is a comprehensive, up-to-date reference for researchers. It discusses problems concerning the function and structure of the thalamus and concludes each chapter with thought-provoking questions regarding future research.

  • Channelopathies

    • 1st Edition
    • F. Lehmann-Horn + 1 more
    • English
    This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

  • Cognition, Emotion and Autonomic Responses: The Integrative Role of the Prefrontal Cortex and Limbic Structures

    • 1st Edition
    • Volume 126
    • H.B.M. Uylings + 4 more
    • English
    Since the publication of the previous volume on the prefrontal cortex: its structures, function and pathology in Progress in Brain Research some ten years ago, new data has emerged on the prefrontal cortex and its connections and interactions with structures involved in emotional, motivational and autonomic responses. Cognition, memory and decision making appear to be influenced by emotional and autonomic responses from viscera and the internal state of the organism (e.g. 'gut feelings') induced by the outside world. This resulted in a renewed interest in the interactions of circuits involved in cognition, memory and decision making with those involved in emotional and motivational responses. Therefore, the 21st International Summer School of Brain Research, held in Amsterdam, 23-27 August 1999, was entirely devoted to the question to which extent the prefrontal cortex and related limbic structures function as an integrative center for these interactions.

  • Nervous System Plasticity and Chronic Pain

    • 1st Edition
    • Volume 129
    • J. Sandkühler + 2 more
    • English
    The mechanisms underlying the various forms of neuropathic pain are explored by leading experts in the field. The reviews provide state-of-the-art knowledge in pain research from the molecular and cellular level up to imaging of pain in the human cortex and to the perception of pain. In a truly interdisciplinary approach pain researchers and pain therapists give insights into the latest developments in the field. Some symptoms of neuropathic pain can now be understood at the molecular level, e.g. by modifications in the subunit composition of sodium channels or by the molecular properties of the vanilloid receptor. Synaptic mechanisms similar to those involved in learning and memory formation have now been discovered in pain pathways and real-time images of brain activity in human patients give novel insights into the differential processing of sensory-discriminati... versus emotional-aversive aspects of pain. This volume also documents another remarkable achievement in pain research during the past decade: The development of a common language and the assimilation of scientific concepts across disciplines. When reading the contributions, it becomes clear that new concepts and ideas developed in one arena of pain research have had impact on concepts and hypotheses important to other fields of pain research. Much of the foundation on which future pain research will rest is described in this volume. Numerous cross-references between the chapters and a detailed subject index make this book highly accessible to the reader.

  • Volume Transmission Revisited

    • 1st Edition
    • Volume 125
    • L.F. Agnati + 3 more
    • English
    Volume Transmission Revisited describes the mounting evidence that cells of the central nervous system are able to communicate via a host of chemical signals that flow through the extracellular space. Volume transmission (VT) constitutes a novel and complementary communication system to classical synaptic transmission. The new modality, which does not require specific connections between cells, leads to a reconsideration of the spatial relationships of neurons and glia, brings a new dimension to network modelling and is relevant to both short term interactions and long term tonic states of the brain.The reader will find 29 chapters describing many of the major discoveries in VT during the last decade.The most striking feature of this publication is the collecting together of many compelling examples of the ubiquitous nature of VT. These point to its increasing relevance from basic neuroscience research to clinical practice. Those working in other areas will find numerous invaluable examples of how leading investigators have gone about assembling evidence for VT.

  • Glutamate

    • 1st Edition
    • Volume 18
    • J. Storm-Mathisen + 1 more
    • English
    The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).

  • Neural Plasticity and Regeneration

    • 1st Edition
    • Volume 128
    • F.J. Seil
    • English
    While a cure for spinal cord injury remains elusive, the contents of this volume convey a sense of progress towards this goal. More has been learned about the primary and secondary consequences of spinal cord injury and more is being understood about recovery mechanisms that are intrinsic to the nervous system and that might be further encouraged. Expanding the control capacity of uninjured portions of the nervous system may be one approach to improving the functional capabilities of those afflicted with this disorder. New therapies in the form of transplantable cells that can encourage growth or myelination or prevent secondary damage or that can substitute for injured cells appear promising for future applications. Genetic and tissue engineering studies give us further hope, and under continuous development are novel drugs with greater specificity and fewer detrimental effects and improved delivery methods for such drugs. The volume is organized into six topic sections, including I) Strategies for Spinal Cord Injury Repair, II) Plasticity of the Injured Spinal Cord: Retraining Neural Circuits to Promote Motor Recovery, III) Impact of Neuroprosthetic Applications on Functional Recovery, IV) Neurotrophins and Activity-Dependent Plasticity, V) Candidate Cells for Transplantation into the Injured CNS and VI) New Directions in Regeneration Research. Both clinical and experimental animal studies are presented in the first three sections, while predominantly basic research is the focus of the second half of the book.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 40
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. Volume 40 includes in its coverage chapters on memory, categorization, implicit and explicit learning, and the effects of rewards and punishments on learning.

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