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Elsevier

Books in Carcinogenic and genetic toxicology

Focusing on chemical and genetic factors linked to cancer, this collection supports researchers, toxicologists, and regulatory agencies. It features studies on mutagenicity, genotoxicity testing, and carcinogen risk assessment, fostering understanding of cancer mechanisms and safe exposure limits to protect public health.

  • Micro(nano)plastics in Organ Systems

    Health Impacts, Challenges, and Future Prospects
    • 1st Edition
    • Charan Singh + 4 more
    • English
    Micro(nano)plastics in Organ Systems: Health Impacts, Challenges, and Future Prospects comprehensively discusses the impact of micro(nano)plastics on human health, analyzing their sources, classification, and exposure pathways, while exploring their interactions with biological systems, the potential effects on various organ systems, and concerns related to bioaccumulation and toxicity. The book begins with an in-depth analysis of their classification, sources, and exposure pathways, and progressing through interactions with biological systems and the resulting toxicological effects. The text meticulously examines the implications of these particles on various organ systems—including the gastrointestinal, respiratory, cardiovascular, renal, neurological, reproductive, and metabolic systems—while addressing critical issues such as bioaccumulation, immunological responses, and their potential harmful impact on health. Furthermore, the book delves into recent advances in detection technologies, the development of more sustainable advances such as bioplastic-based nanoparticles, and the pressing need for regulatory frameworks to mitigate the health risks associated with micro(nano)plastics. It is an essential resource for toxicologists, environmental scientists, healthcare professionals, public health advocates, and others interested in the implications of micro(nano)plastics on health.

  • Immunotoxicogenomics

    A Multidisciplinary Approach in Systems Toxicology
    • 1st Edition
    • Md. Naimat Ali + 2 more
    • English
    Immunotoxicogenomics... A Multidisciplinary Approach in Systems Toxicology covers the major mechanisms and effects of toxic substances on the immune system, and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, and emerging and future trends. The book begins with a discussion of the systemic approach to toxicants, but also looks at current genomic tools used to assess immunotoxicity and systems biology methods used in immuno-toxicogenomic... Other topics include genomic expression profiling, gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomic... as a screening tool, and the assessment and analysis of Immunotoxicogenomics data.This book provides a collaborative, multidisciplinary approach for researchers in the fields of toxicology, genetics, immunology, and others engaged in the study on the effects of toxic substances on immune responses.

  • Companion and Complementary Diagnostics

    From Biomarker Discovery to Clinical Implementation
    • 1st Edition
    • Jan Trøst Jørgensen
    • English
    Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies.

  • Mutagenicity: Assays and Applications

    • 1st Edition
    • Ashutosh Kumar + 3 more
    • English
    Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.

  • Genetic Toxicology Testing

    A Laboratory Manual
    • 1st Edition
    • Ray Proudlock
    • English
    Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own.

  • Thresholds of Genotoxic Carcinogens

    From Mechanisms to Regulation
    • 1st Edition
    • Takehiko Nohmi + 1 more
    • English
    Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.

  • Toxicogenomics-Based Cellular Models

    Alternatives to Animal Testing for Safety Assessment
    • 1st Edition
    • Jos Kleinjans
    • English
    Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

  • Handbook of Mutagenicity Test Procedures

    • 2nd Edition
    • B.J. Kilbey + 3 more
    • English
    The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

  • Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens

    • 1st Edition
    • Richard P. Pohanish
    • English
    The fourth edition of this classic reference by Marshall Sittig presents expansive chemical, health, and safety data for over 1,500 chemicals in the plastics, pharmaceuticals/biot... energy, cleaning solvents, agriculture and other industries. The chemicals are presented alphabetically and classified as a carcinogen, hazardous substance, hazardous waste, or toxic pollutant. Chemical data cover description, exposure limits, harmful effects, first aid, and storage among the other important information included to make appropriate response decisions. Highlights of the expanded information include:• A comprehensive CAS index with the new US, CAS, and RTECS numbers and the DOT ID for all chemicals listed.• The EEC and EINECS international numbers.• International regulatory authority references (US, Canada, Mexico, Europe; federal and local levels).• Chemical formulas.• Detailed physical properties data.• Chemical incompatibility information.• Information about medical surveillance, respirator requirements, first aid, spill, fire and emergency response (including initial isolation and protection action distances), and disposal requirements.• Greatly expanded chemical synonym and trade-name indexes, including international names.• User-friendly synonym listings with cross-references tied to the primary (generic) name.

  • Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens

    • 5th Edition
    • Richard P. Pohanish
    • English
    For more than a quarter century, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens has proven to be among the most reliable, easy-to-use and essential reference works on hazardous materials. Sittig's 5th Edition remains the lone comprehensive work providing a vast array of critical information on the 2,100 most heavily used, transported, and regulated chemical substances of both occupational and environmental concern.Information is the most vital resource anyone can have when dealing with potential hazardous substance accidents or acts of terror. Sittig's provides extensive data for each of the 2,100 chemicals in a uniform format, enabling fast and accurate decisions in any situation. The chemicals are presented alphabetically and classified as a carcinogen, hazardous substance, hazardous waste, or toxic pollutant. This new edition contains extensively expanded information in all 28 fields for each chemical (see table of contents) and has been updated to keep pace with world events. Chemicals classified as WMD have been included in the new edition as has more information frequently queried by first responders and frontline industrial safety personnel.