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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • The Evaluation of Toxicological Data for the Protection of Public Health

    Proceedings of the International Colloquium, Luxembourg, December 1976
    • 1st Edition
    • W. J. Hunter + 1 more
    • English
    The Evaluation of Toxicological Data for the Protection of Public Health: Proceedings of the International Colloquium, Luxembourg, December 1976 focuses on the review of toxicological tests and methods used in toxicological evaluation of chemicals and reconsideration of these procedures in identifying decision-making processes involved in the protection of public health. The selection first discusses reviews of toxicological tests, including introductory remarks and comments on acute toxicity; problems associated with the testing of environmental mutagens; and the testing of carcinogenic potentials. The publication also examines the uncertainties related to the evaluation of the health hazards of environmental chemicals from toxicological data and epidemiological monitoring of indices of chemical hazards. The book takes a look at safety factors and their application in toxicological evaluation; ecotoxicological approaches for the protection of environment and health; and use of biological materials as environmental pollution gauges. The text also discusses acute toxicity, teratogenic effects of pollutants, and examples of ecotoxicological research. The selection is a dependable source of data for readers interested in the evaluation of toxicological data relative to the protection of public health.

  • Pharmacology of Pain

    Proceedings of the First International Pharmacological Meeting, Stockholm, 22-25 August, 1961
    • 1st Edition
    • R. K. S. Lim + 2 more
    • English
    Pharmacology of Pain, Volume 9 presents the proceedings of the 3rd International Pharmacological Meetings held in Sao Paulo in 1966. The book includes papers on the mediators of pain; proteolytic enzymes as mediators of pain; and desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors. The text also covers the sensitization of nociceptors by 5-hydroxytryptamine in man; the possible role of serotonin in affective component of pain behavioral reaction in the rat; and the use of pain induced functional impairment for assessing analgesic action. Papers on the clinical pharmacology of analgesics and analgesic antagonists; behavioral mechanisms of human pain; and central nervous mechanisms involved in pain and analgesia are also considered. The book further tackles the neuropharmacology of pain and analgesia; the interrelationship of cortical and subcortical pain systems; and the interaction of fast- and slow-conducting fiber systems involved in pain and analgesia.

  • Fungal Toxins

    A Comprehensive Treatise
    • 1st Edition
    • Alex Ciegler + 2 more
    • English
    Microbial Toxins, Volume VI: Fungal Toxins covers information on the evaluation of the chemical, biological, and biomedical aspects of the fungal toxins. The book discusses the historical structure chemistry, production, analysis, detoxification, biosynthesis, pharmacology, toxicology, and molecular biochemistry of aflatoxins and related compounds. The text also describes the isolation, analysis, production, chemistry, biological effects, and biogenesis of the ochratoxins, as well as the bioproduction, biosynthesis, and chemical properties of misclellaneous Aspergillus toxins. Various species of storage fungi, including yellowed rice toxins, luteoskyrin and related compounds, chlorine-containing compounds, citrinin, and citreoviridin are also considered. The book further tackles the physical and chemical properties and the biological activity of the rubratoxins; the biosynthesis and biochemical effects of patulin, penicillic acid, and other carcinogenic lactones; as well as the structure, production, biosynthesis, and biological effects of cyclopiazonic acid and related toxins. The text also encompasses bioproduction, properties, chemical structure, and biological activity of miscellaneous Penicillium toxins. Microbiologists, biochemists, epidemiologists, pharmacologists, toxicologists, medical students and people involved in other related fields will find the book useful.

  • Introduction to the Principles of Drug Design

    • 1st Edition
    • H. J. Smith + 1 more
    • English
    Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.

  • Bacterial Endotoxins

    A Comprehensive Treatise
    • 1st Edition
    • Solomon Kadis + 2 more
    • English
    Microbial Toxins, Volume V: Bacterial Endotoxins covers the physiology, pathology, and immunology of bacterial endotoxins. The book discusses the relationship of lipopolysaccharide structure to bacterial virulence; the importance of blood-group and Forssman antigenic determinants in interactions between human and microbes; and the chemical modification of endotoxin and inactivation of its biological properties. The text also describes the effects of endotoxic lipopolysaccharides on the complement system; the host-dependent detoxification of bacterial endotoxin; and the metabolic effects of bacterial endotoxins. The release of vasoactive agents and the vascular effects of endotoxin are also considered. The book further tackles the febrile response to endotoxin; some major aspects and the relationship between shock and endotoxemia; as well as the effects of lipopolysaccharides (endotoxins) on the susceptibility to infections. The text also encompasses the role of hypersensitivity and tolerance in reactions to endotoxins. Pathologists, immunologists, physiologists, and microbiologists will find the book invaluable.

  • Molecular Biological Markers for Toxicology and Risk Assessment

    • 1st Edition
    • Bruce A. Fowler
    • English
    Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice.

  • Current Concepts in Kinin Research

    Proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology, Paris, 22 July 1978
    • 1st Edition
    • Gert L. Haberland + 1 more
    • English
    Current Concepts in Kinin Research contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Paris on July 22, 1978. The book is organized into four parts. Part I explains the functions and mechanisms of the kinin system. Part II focuses on kallikreins and the methods of their determination. Part III describes the intrinsic blood clotting and plasma kinin formation. The last part deals with the characterization of plasma kininogens.

  • Pharmacology for Student and Pupil Nurses and Students in Associated Professions

    • 2nd Edition
    • Bernard R. Jones
    • English
    Pharmacology for Student and Pupil Nurses and Students in Associated Professions is based on lectures that have been updated and presented to nurses in training for the State Registration and State Enrolment Examinations and to Students in Dispensing. This book describes therapies and drug trends in the industry, as well as many types of drugs, their administration, dosage, usage, and effects. Functions of the pertinent human anatomy are included to illustrate the absorption of these drugs. This book includes a section on patient counseling; the use of the International System of Units (SI); and the immune-response process related to specialized fields of treatment. Patient counseling is undertaken for patients who will continue treatment at home. The nurse gives proper advice on the administration of the patient's medicine. SI was adopted to enhance the standardization of the unit of measurement for volume, weight, temperature, and length. This standard includes the use of the terms Celsius, millimole, and joule and the way of writing abbreviations and numbers in the Metric system. The immune-response process deals with the mechanism and related aspects concerning the two groups of cytotoxics, antimitotics and antimetabolites. The side effects of these drugs when used, for example, in chemotherapy, are discussed. This book will prove useful to pharmacists, student pharmacy technicians, professors of pharmacology, practitioners of general medicines, and specialists with interests in drug therapy.

  • Genetic Toxicology Testing

    A Laboratory Manual
    • 1st Edition
    • Ray Proudlock
    • English
    Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own.

  • Thresholds of Genotoxic Carcinogens

    From Mechanisms to Regulation
    • 1st Edition
    • Takehiko Nohmi + 1 more
    • English
    Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.

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